Toxicity/Substance Abuse

Sweis, Rochelle; Biller, José

doi:10.1016/b978-0-12-803058-5.00120-x

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…Although all the OCT-A parameters obtained in the current study regarding Behçet uveitis smokers cases were less than non smokers ones with a significant change(Pvalues <0.0001) * within vessel density of the fovea &parafovea. Table 4: Comparison of the capillary vessel densities among Behçet disease without uveitis according to smoking status as examined by OCT-A -Independent sample T-Test test for quantitative data between the groups -Significant level at P value < 0.05 Table (5) demonstrates a comparison of the foveal avascular area parameters among studied cases according to smoking status.Average avascular foveal zone area &circularity measured at the capillary plexus was larger in Behçet uveitis BU-cases &BD without uveitis than normal controls with a significant difference (P-values <0.0001*).Average FAZ perimeter was nearly similar among non smokers .However, average FAZ perimeter is larger in somkers BD without uveitis than smokers normal controls without a significant difference (p= 0.204). 7) demonstrate a Comparison of the foveal avascular area parameters among behcet disease patients according to smoking status.Average avascular foveal zone area ,perimeter &circularity measured at the capillary plexus was larger in behcet disease smokers than non smokers patients with a statistically significant difference.…”

Section: Resultsmentioning

confidence: 99%

“…Smoking is the most extensive habit of men. In the cigarette, there are more than 4,000 toxic constituents that influence the vascular and immune system by including vasospasm and platelet aggregation and lessening the anti-oxidants in the blood (5). Smoking is as well accompanyed with several ocular disorders, like dry eye, Graves ophthalmopathy, cataract, cystoid macular edema (CME), agelinked macular degenerations, and uveitis (6).…”

Section: Introductionmentioning

confidence: 99%

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Impacts of smoking & ocular activity on Behcet disease & normal control by optical coherence tomography angiography (OCTA) in Upper Egypt

Saif

Ismaeel

Sayed

et al. 2022

ijhs

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Retinal vasculitis and vein occlusions are common causes of serious visual loss in Behcet’s disease. The aim of the current work was the comparison of the OCTA results of BU cases, BD without uveitis cases &normal control was further subdivided to smokers &non-smokers to permit us to recognize retinal micro-circulation variations at the macular level in BU cases even in the nonattendance of preceding angiographic diagnosing of vasculitis & impact of smoking on BD clinical results of Behcet uveitis(BU), Behcet disease with no uveitis cases &normal control by the following parameters; Vessel density of macular area (VD) & foveal Avascular zone (FAZ) using OCTA. The conclusion of this study shows reduction of vessel density of macular area in Behcet uveitis (BU) rather than Behcet disease without uveitis &normal control & Enlarged FAZ in BU rather than BD without uveitis & normal control. The study results revealed areas of hypoperfusion of macular area even in BD without clinical signifacnce. Hazards of smoking on uveitis cases . There is a need to larger samples & lack of stable treatment protocols.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impacts of smoking & ocular activity on Behcet disease & normal control by optical coherence tomography angiography (OCTA) in Upper Egypt

Saif

Ismaeel

Sayed

et al. 2022

ijhs

View full text Add to dashboard Cite

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Analytical techniques for the detection of amphetamine-type substances in different matrices: A comprehensive review

Drăgan

Parrilla

Feier

et al. 2021

TrAC Trends in Analytical Chemistry

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Neuroprotective Methodologies of Co-Enzyme Q10 Mediated Brain Hemorrhagic Treatment: Clinical and Pre-Clinical Findings

Rajdev

Mehan

2019

CNSNDDT

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: Cerebral brain hemorrhage is associated with the highest mortality and morbidity despite only constituting approximately 10-15% of all strokes classified into intracerebral and intraventricular hemorrhage where most of the patients suffer from impairment in memory, weakness or paralysis in arms or legs, headache, fatigue, gait abnormality and cognitive dysfunctions. Understanding molecular pathology and finding the worsening cause of hemorrhage will lead to explore the therapeutic interventions that could prevent and cure the disease. Mitochondrial ETC-complexes dysfunction has been found to increase neuroinflammatory cytokines, oxidative free radicals, excitotoxicity, neurotransmitter and energy imbalance that are the key neuropathological hallmarks of cerebral hemorrhage. Coenzyme Q10 (CoQ10), as a part of the mitochondrial respiratory chain can effectively restore these neuronal dysfunctions by preventing the opening of mitochondrial membrane transition pore, thereby counteracting cell death events as well as exerts an anti-inflammatory effect by influencing the expression of NF-kB1 dependent genes thus preventing the neuroinflammation and energy restoration. Due to behavior and biochemical heterogeneity in post cerebral brain hemorrhagic pattern different preclinical autologous blood injection models are required to precisely investigate the forthcoming therapeutic strategies. Despite emerging pre-clinical research and resultant large clinical trials for promising symptomatic treatments, there are very less pharmacological interventions demonstrated to improve post operative condition of patients where intensive care is required. Therefore, in current review, we explore the disease pattern, clinical and pre-clinical interventions under investigation and neuroprotective methodologies of CoQ10 precursors to ameliorate post brain hemorrhagic conditions.

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Toxicity/Substance Abuse

Cited by 3 publications

References 56 publications

Impacts of smoking & ocular activity on Behcet disease & normal control by optical coherence tomography angiography (OCTA) in Upper Egypt

Impacts of smoking & ocular activity on Behcet disease & normal control by optical coherence tomography angiography (OCTA) in Upper Egypt

Analytical techniques for the detection of amphetamine-type substances in different matrices: A comprehensive review

Neuroprotective Methodologies of Co-Enzyme Q10 Mediated Brain Hemorrhagic Treatment: Clinical and Pre-Clinical Findings

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