Toxicity Study of <i>Achyranthus aspera</i>

Abstract

The objectives of present work focuses to check the acute and sub acute toxicity studies for the Achyranthes aspera L methanol extract as per OECD guideline in Swiss mice. The dose of 100, 200, 250 gm/kg body weight methanol extract by administering drug intraperitoneally and recorded the growth, body weight, organ weight, general symptoms, morphological and physiological behavior, mortality. These parameters on various organs system in mice were studied. It was considered necessary to assess its potential health hazard in man and to find the safe and effective dose. The observations of changes in body weight, food and water intake as well as cage side observations were reported. There was no abnormality observed in all groups. The whole plant powder methanol extract of Achyranthes Aspera L were found to be nontoxic.

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“…The entire plant powder methanol extract was shown to be nontoxic. Hence, this species is reasonably hopeful as a multipurpose and multi-constituents medicinal agent, consequently supplementary clinical trials should be achieved to corroborate its effectiveness [104]. Carried out with Costus afer ker aqueous extract, acute oral toxicity studies in male and female albnino Wistar mice, weighing between 28 and 35g, did not shown any sign of acute toxicity or death even at the dose of 4,000mg/kg.…”