Toxicity Study of <i>Achyranthus aspera</i>

Abstract

The objectives of present work focuses to check the acute and sub acute toxicity studies for the Achyranthes aspera L methanol extract as per OECD guideline in Swiss mice. The dose of 100, 200, 250 gm/kg body weight methanol extract by administering drug intraperitoneally and recorded the growth, body weight, organ weight, general symptoms, morphological and physiological behavior, mortality. These parameters on various organs system in mice were studied. It was considered necessary to assess its potential health hazard in man and to find the safe and effective dose. The observations of changes in body weight, food and water intake as well as cage side observations were reported. There was no abnormality observed in all groups. The whole plant powder methanol extract of Achyranthes Aspera L were found to be nontoxic.

Evaluation of acute and sub-acute toxicity of selected traditional antiurolithiatic medicinal plant extracts in Wistar albino rats

“…A significant reduction in the activities of alkaline phosphatase (ALP) following A. aspera extract administration is suggestive of its anti-urolithic potential of the plant extract similar to a study on Phyllanthus niruri extract, which had demonstrated that the decrease in ALP level contributes to a reduction in the number of renal calculi [ 59 ]. Furthermore, it was reported that A. aspera extract have hepatoprotective activity against paracetamol-induced toxicity at dose 250 mg/kg b.w [ 60 ] and it is non-toxic administered intraperitoneally in rats [ 40 ], which is a good indication that would justify its use as an antiurolithic treatment.…”

“…It is also used to treat a scorpion bite, gonorrhea, obstetric disorders, and diabetes mellitus, fever, dysentery, and prevents hypersensitivity reactions (anti-allergic) of the skin [ 39 ]. It also shows the effects of nephroprotective, antiparasitic, hypoglycaemic, analgesic, antipyretic, and purgative [ 40 ]. Rumex abyssinicus Jacq.…”

Efficacy of Achyranthes aspera (L.) as a Molluscicidal Bait Formulation against Fresh Water Snail Biomphalaria pfeifferi

“…There are studies regarding the toxicological and pharmacological aspects of A. aspera . Many researches investigated no significant mammalian toxicity of the plant [ 38 , 39 ]. Rather, its antioxidant and anti-inflammatory properties due to the presence of saponins, alkaloids, and oleanolic acid [ 40 , 41 ] are well known.…”

Analysis of Achyranthes aspera leaf extract and environmental safety evaluation to non target Nile tilapia fish fingerlings, Oreochromis niloticus.

“…It is a well-known medicinal plant in Ethiopia, India and other countries as antifungal, antibacterial, antioxidant, antifertility and in the treatment of renal dropsy, skin rash, chronic malaria, impotence, asthma, diabetes etc. [14][15][16]. Very recently, The molluscicidal property of A. aspera is discovered by after investigation on the aqueous and ethanolic extracts as well as in bait formulation [17,18].…”