Toxicity study of ionic liquid, 1-butyl-3-methylimidazolium bromide on guppy fish, Poecilia reticulata and its biodegradation by soil bacterium Rhodococcus hoagii VRT1

Thamke, Viresh; Kodam, Kisan M.

doi:10.1016/j.jhazmat.2016.08.056

Cited by 34 publications

(12 citation statements)

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“… HepG2 cells incubated in [C 16 mim][Cl] (Wan et al 2018 ). Human blood lymphocytes cells (Thamke et al 2017 ) and in guppy fish Poecilia reticulata liver cells (Thamke and Kodam 2016 ) incubated in [C 10 mim][BF 4 ] and [BTDA][Cl]. CCO cells incubated in [C 4 mim]-based ILs (Radošević et al 2013 ).…”

Section: Mechanisms Of Action Of Ilsmentioning

confidence: 99%

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Mechanisms of action of ionic liquids on living cells: the state of the art

2020

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Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic cation and either an organic or inorganic anion, whose melting temperature falls around room-temperature. In the last 20 years, the toxicity of ILs towards cells and micro-organisms has been heavily investigated with the main aim to assess the risks associated with their potential use in (industrial) applications, and to develop strategies to design greener ILs. Toxicity, however, is synonym with affinity, and this has stimulated, in turn, a series of biophysical and chemical-physical investigations as well as few biochemical studies focused on the mechanisms of action (MoAs) of ILs, key step in the development of applications in bio-nanomedicine and bio-nanotechnology. This review has the intent to present an overview of the state of the art of the MoAs of ILs, which have been the focus of a limited number of studies but still sufficient enough to provide a first glimpse on the subject. The overall picture that emerges is quite intriguing and shows that ILs interact with cells in a variety of different mechanisms, including alteration of lipid distribution and cell membrane viscoelasticity, disruption of cell and nuclear membranes, mitochondrial permeabilization and dysfunction, generation of reactive oxygen species, chloroplast damage (in plants), alteration of transmembrane and cytoplasmatic proteins/enzyme functions, alteration of signaling pathways, and DNA fragmentation. Together with our earlier review work on the biophysics and chemical-physics of IL-cell membrane interactions (Biophys. Rev. 9:309, 2017), we hope that the present review, focused instead on the biochemical aspects, will stimulate a series of new investigations and discoveries in the still new and interdisciplinary field of “ILs, biomolecules, and cells.”

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Section: Mechanisms Of Action Of Ilsmentioning

confidence: 99%

“…Human blood lymphocytes cells (Thamke et al 2017 ) and in guppy fish Poecilia reticulata liver cells (Thamke and Kodam 2016 ) incubated in [C 10 mim][BF 4 ] and [BTDA][Cl].…”

Section: Mechanisms Of Action Of Ilsmentioning

confidence: 99%

Mechanisms of action of ionic liquids on living cells: the state of the art

2020

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“…In contrast to that expected, ILs containing shorter alkyl side chains present the highest biodegradation levels. Thamke and Kodam have also explored other potential strains of microorganisms that are able to biodegrade ILs. Incubation of [bmim]Br with Rhodococcus hoagii for 8 days results in a decrease in the BOD and DOC levels by 58 and 60 %, respectively.…”

Section: Degradation Of Ionic Liquidsmentioning

confidence: 99%

“…However, studies with [bmim]Br show that high concentrations of this compound can induce DNA damage in the liver cells of P. reticulate . Moreover, exposure to high concentrations of [bmim]Br increases the activity of the CAT, glutathione S‐transferase, and SOD antioxidant enzymes, which induces oxidative cell damage . The effect of 11 common amidinium‐, imidazolium‐, and phosphonium‐based ILs on zebrafish Danio rerio and Chinese hamster ovary cells (CHO) has been determined by Ruokonen et al .…”

Section: Toxicological Impact Of Ionic Liquidsmentioning

confidence: 99%

Environmental Impact of Ionic Liquids: Recent Advances in (Eco)toxicology and (Bio)degradability

et al. 2017

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This Review aims to integrate the most recent and pertinent data available on the (bio)degradability and toxicity of ionic liquids for global and critical analysis and on the conscious use of these compounds on a large scale thereafter. The integrated data will enable focus on the recognition of toxicophores and on the way the community has been dealing with them, with the aim to obtain greener and safer ionic liquids. Also, an update of the most recent biotic and abiotic methods developed to overcome some of these challenging issues will be presented. The review structure aims to present a potential sequence of events that can occur upon discharging ionic liquids into the environment and the potential long-term consequences.

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“…More recently, signicant efforts have been made to assess IL (eco)toxicity and biodegradability in order to avoid potential risks. [12][13][14][15] ILs toxicity has been assessed using diverse biological models, such as bacteria, 15 fungi, 16 invertebrates, 17 algae, 18 sh, 19 plants, 20 and cells. 21 ILs biodegradability has been evaluated using standardized assays approved by the Organization for Economic Cooperation and Development (OECD) and the International Organization for Standardization (ISO), such as the dissolved organic carbon die-away test (OECD 301A), closed-bottle test (OECD 301D), and CO 2 headspace test (ISO 14593).…”

Section: Introductionmentioning

confidence: 99%