Toxicity study of ethanolic stem bark extract of Xylopia aethiopica on fertility indexes in male rats: An experimental study

Ehigiator, Ben Enoluomen; Adikwu, Elias

doi:10.18502/ijrm.v13i4.6889

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…[ 39 ] Studies have shown that impaired levels of the aforementioned hormones can arrest spermatogenesis. [ 40 ] In the present study, treatment with BPA decreased LH, FSH and testosterone hormone and increased progesterone and estradiol hormones. Similarly, Alboghobeish et al .…”

Section: Discussionsupporting

confidence: 60%

Glutamine supplementation attenuates bisphenol a-induced testicular toxicity in rats

2022

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Section: Discussionsupporting

confidence: 60%

Glutamine supplementation attenuates bisphenol a-induced testicular toxicity in rats

2022

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“…Indeed, the phytochemical screening performed by Benson [9] ; Tine [43] and Gnamien [44] on Zanthoxylum leprieurii revealed the presence of tannins, flavonoids, terpenoids, alkaloids. The work of the following authors Oso [33] ; Ehigiator and Adikwu [45] revealed the presence of tannins, flavonoids, leucoanthocyanins, terpenoids, saponosides, and steroids in the fruits of Xylopia aethiopica. These same compounds were found in extracts of Harungara madagascariensis [46,47].…”

Section: Discussionmentioning

confidence: 99%

The Impact of the Recipe from Zanthoxylum leprieurii Bark, Harungara madagascariensis Leaves and Xylopia aethiopica Fruits on Nociception and Inflammation in Wistar Rats

Kple

Akakpo-Akue²,

Ouattara³

et al. 2023

IJBcRR

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Inflammation has a major role in the pathophysiology of sickle cell disease, in fact when it is recurrent, it contributes more to the obstruction of blood vessels through several biochemical mechanisms by provoking vaso-occlusive crises. In order to mitigate these adverse effects in sickle cell patients, the analgesic and anti-inflammatory potentials of extracts of a combination of organs of three plants were evaluated in this study. The analgesic and anti- inflammatory activities of the aqueous (DZHm) and hydroethanolic (EZHm) extracts (200, 400 and 800 mg/kg) were evaluated in rats as models of acetic acid-induced torsion and Carrageenan-induced hind paw edema, using Diclofenac and Ibuprofen as reference molecules. Oral administration of ZHm extracts at doses of 200, 400 and 800 mg/kg produced anti-inflammatory and analgesic effects. These extracts significantly reduced edema and pain. These effects are time and dose dependent. In terms of analgesic effect, the dose of 800 mg/kg bw generated a high inhibition rate of 84.51% and 73.06% for DZHm and EZHm respectively, while the inhibition percentage of Ibuprofen was 78.3 ± 2.09 at the dose of 100 mg/kg bw. The anti-inflammatory effect was 60, 55% for DZHm, 56.08% for EZHm and 62.91% for Diclofenac at 10 mg/kg Pc. Diclofenac and Ibuprofen used for these two tests generated similar activities with ZHm extracts at the dose of 800 mg/kg Pc. The tested extracts (DZHm and EZHm) have analgesic and peripheral anti-inflammatory potentials justifying the use of this recipe in the traditional environment.

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“…Rich is a sweet-smelling evergreen medicinal plant usually found in the forest-Savannah zone and the rainforest region of Africa [176]. Various parts of the plant including fruit, leaves, stem, stem bark and root are utilized in folk medicine for the treatment of different diseases and health disorders such as rheumatism, asthma, infertility, dysentery, epilepsy, candidiasis, fever and malaria [177][178][179]. The in vitro antimalarial effect of the volatile oil of X. aethiopica seed was evaluated against P. falciparum 3D7 strain, a moderate activity against the malaria parasite was observed with an IC50 of 14 µg/ml [180].…”

Section: Persea Americanamentioning

confidence: 99%

Indigenous medicinal plants used in folk medicine for malaria treatment in Kwara State, Nigeria: An ethnobotanical study

Evbuomwan

Adeyemi

Oluba

2023

Preprint

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Background Folk medicine is crucial to healthcare delivery in the underdeveloped countries. It is frequently used as a primary treatment option or as a complementary therapy for malaria treatment. Malaria is a deadly disease which greatly threatens global public health, claiming incredible number of lives yearly. The study was aimed at documenting the medicinal plants used for malaria treatment in folk medicine in Kwara State, Nigeria.Methods Ethnobotanical information was collected from selected consenting registered traditional medicine practitioners (TMPs) through oral face-to-face interviews using in-depth, semi-structured questionnaires. Data were analysed and discussed in relation to published literature on the documented plants.Results Sixty-two indigenous medicinal plants including 13 new plants used for malaria treatment were identified in this study. The TMPs preferred decoction in aqueous solvent (34%) and steeping in decaffeinated soft drink (19%) for herbal preparations. Oral administration (74%) was the main route of administration, while leaves (40%) and stem barks (32%) were the most dominant plant parts used in herbal preparations. The most cited families were Fabaceae (15%) and Rutaceae (6%), while Mangifera indica (77.14%), Enantia chlorantha (65.71%), Alstonia boonei (57.14%) followed by Cymbopogon citratus (54.29%) were the most used plants. Besides, the antimalarial activities of many of the plants recorded and their isolated phytocompounds have been demonstrated. Furthermore, the conservation status of 4 identified plants were Vulnerable.Conclusion The study showed strong ethnobotanical knowledge shared by the TMPs in the State and provides preliminary information that could be explored for discovery of more potent antimalarial compounds.

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Toxicity study of ethanolic stem bark extract of Xylopia aethiopica on fertility indexes in male rats: An experimental study

Cited by 6 publications

References 10 publications

Glutamine supplementation attenuates bisphenol a-induced testicular toxicity in rats

Glutamine supplementation attenuates bisphenol a-induced testicular toxicity in rats

The Impact of the Recipe from Zanthoxylum leprieurii Bark, Harungara madagascariensis Leaves and Xylopia aethiopica Fruits on Nociception and Inflammation in Wistar Rats

Indigenous medicinal plants used in folk medicine for malaria treatment in Kwara State, Nigeria: An ethnobotanical study

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