Toxicity Studies Related to Medicinal Plants

Kavimani, S; Sankaramourthy, Divya; Gunasekaran, M.

doi:10.1016/b978-0-08-102081-4.00018-6

Cited by 27 publications

(20 citation statements)

References 25 publications

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“…More researches are conducted every day on medicinal plants and its constituents which will enable the researchers to explore their toxicity potentials, as they produce a broad scope of drugs which are of therapeutic benefit. 4,5 Therefore, toxicological studies in experimental animals should be considered as an important requirement in establishing the harmful effects of the phyto-constituent. 6 The rapid growing popularity in the uses of medicinal plants nowadays is as aresult of the believed that medicinal plants are safer than orthodox medicines.…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostic and Safety Assessment of Hydro-Methanol Leaf Extract of Annona muricata Linn (Annonacea) in Male Wistar Rats

2021

TJNPR

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are natural in the plants as shown in some of the previous studies. 7 A.muricata L., commonly known as graviola, sirsak, soursop, guanabana, belongs to the Annonaceae family with approximately 130 genera and 2300 species 8,9 . A. muricata is indigenous in the warmest tropical regions in North and South America now widely distributed in the tropical and subtropical parts of the world, including Nigeria, India, Malaysia. 10 A. muricata is an evergreen, terrestrial plant reaching 5-8 m in height with large green leaves together with an open roundish canopy. The fruits are large, green and heart-shaped. 11 Some minerals, vitamins, bioactive chemical substances are found in the fruits, while the other plant parts contain many amounts of bioactive chemical substances such as flavonoids, cyclopeptide annomuricatin, acetogenins, alkaloids, oils and terpens 12,13,14 . These compounds are found to be useful in medicine, this is because some acetogenins have antibacterial, antitumoral, insecticidal, antihelminthic properties. 15,16 It was reported that a broad scope of ethno-medicinal activities in Africa and South America widely use this plant in their medicine.

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Section: Introductionmentioning

confidence: 99%

Pharmacognostic and Safety Assessment of Hydro-Methanol Leaf Extract of Annona muricata Linn (Annonacea) in Male Wistar Rats

2021

TJNPR

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“…Man has, for long, depended on ingesting herbs as supplements for body preservation as well as therapy for several ailments such as diarrhoea, lower respiratory tract infection, common cold and skin infections [1,2]. The ingestion of these natural products has increased incredible global endorsement in recent years [3].…”

Section: Introductionmentioning

confidence: 99%

Safety effect of fractions from methanolic leaf extract of Ocimum gratissimum on reproduction in male wistar rats

et al. 2019

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“…The test was conducted to evaluate the safety or hazards of several substances including industrial chemicals, pharmaceutical, and consumer care products. The Organization for Economic and Development (OECD) introduced acute toxicity as the advance effect occurring in a short time of oral administration after a simple or multiple doses is given [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Histology Appearance of Acute Oral Toxicity Study on Ethanol Extract of Psidium Guajava Linn. Fruit in Mice

Atik

Muda

Rahmadi

et al. 2019

Asian J Pharm Clin Res

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Objective:The main objectives of the research are to investigate the phytochemical screening, histology appearance, and safety of acute oral toxicity study on the extract of the fruit of Psidium guajava Linn. in mice. Methods:Mice that were administered by oral feeding with different and controlled dose were divided into three groups, with dose limits of both 2000 and 5000 mg/kg b.w. We analyzed the P. guajava Linn. extract with specific methods before treating the subject. The methods were followed with acute oral toxicity study of Up-and-Down Procedure Organization for Economic and Development 425. The mice were then observed for signs and symptoms of toxicity. In addition, toxicity in the liver and kidney was analyzed through histology observation. Results:Phytochemical screening revealed the presence of flavonoids, quinone, triterpenoid/steroid, tannins and saponins, and the absence of alkaloids. We found that the treatment with 2000 and 5000 mg/kg b.w. of the extract did not show any differences in body weight changes, number of hepatocyte in liver, and podocyte in kidney compared with control (*p>0.05). Moreover, we noticed all mice lived and were healthy during observation. Conclusion:Our finding indicates that the extract of the fruit of P. guajava Linn. is safe and it was not toxic to the liver and kidney.

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Toxicity Studies Related to Medicinal Plants

Cited by 27 publications

References 25 publications

Pharmacognostic and Safety Assessment of Hydro-Methanol Leaf Extract of Annona muricata Linn (Annonacea) in Male Wistar Rats

Pharmacognostic and Safety Assessment of Hydro-Methanol Leaf Extract of Annona muricata Linn (Annonacea) in Male Wistar Rats

Safety effect of fractions from methanolic leaf extract of Ocimum gratissimum on reproduction in male wistar rats

Phytochemical Screening and Histology Appearance of Acute Oral Toxicity Study on Ethanol Extract of Psidium Guajava Linn. Fruit in Mice

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