Toxicity Studies of Genetically Modified Plants: A Review of the Published Literature

Domingo, José L.

doi:10.1080/10408390601177670

Cited by 92 publications

(47 citation statements)

References 53 publications

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“…The author concluded with the question: ''Where is the scientific evidence showing that GM plants/ food are toxicologically safe?'' (Domingo 2007).…”

Section: Introductionmentioning

confidence: 99%

Reduced Fitness of Daphnia magna Fed a Bt-Transgenic Maize Variety

Bøhn

Primicerio

Hessen

et al. 2008

Arch Environ Contam Toxicol

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Genetically modified (GM) maize expressing the Bt-toxin Cry1Ab (Bt-maize) was tested for effects on survival, growth, and reproduction of the water flea Daphnia magna, a crustacean arthropod commonly used as a model organism in ecotoxicological studies. In three repeated experiments, D. magna were fed 100% ground maize in suspension, using either GM or isogenic unmodified (UM) maize. D. magna fed GM-maize showed a significantly reduced fitness performance: The mortality was higher, a lower proportion of females reached sexual maturation, and the overall egg production was lower compared to D. magna fed UM isogenic maize. We conclude that the tested variety of Bt-maize and its UM counterpart do not have the same quality as food sources for this widely used model organism. The combination of a reduced fitness performance combined with earlier onset of reproduction of D. magna fed Bt-maize indicates a toxic effect rather than a lower nutritional value of the GMmaize.

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“…The author concluded with the question: ''Where is the scientific evidence showing that GM plants/ food are toxicologically safe?'' (Domingo 2007).…”

Section: Introductionmentioning

confidence: 99%

Reduced Fitness of Daphnia magna Fed a Bt-Transgenic Maize Variety

Bøhn

Primicerio

Hessen

et al. 2008

Arch Environ Contam Toxicol

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“…With most of the data submitted by the companies to the regulatory authorities being considered as CBI, independent scientific studies concerning potential toxic effects/health risks of GM crops for animals or humans are severely lacking from the scientific literature. As showed by Domingo (2007), few studies (most of them being short-term studies) have been conducted until now. In 2012, Séralini and coworkers published that herbicide-tolerant GM maize and the herbicide Roundup were toxic to rats.…”

Section: Sources Of Informationmentioning

confidence: 97%

GM Food, Nutrition, Safety, and Health

Nordgard¹,

Gronsberg²,

Myhr³

2013

Encyclopedia of Food and Agricultural Ethics

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“…However, before GM rice enters the market, its potential risks need to be assessed for ensuring safety [63,64]. Metabolomics combined with other allergenicity and toxicity tests [22,38] plays an important role in risk management [19]. However, it should be noted that although the survey of the complete metabolome is required for detailed scrutiny of risks, the number of detectable metabolites by currently available metabolomic techniques is limited.…”

Section: Metabolomics For Gm Ricementioning

confidence: 99%

Rice Metabolomics

Oikawa

Mizutani

Kusano

et al. 2008

Rice

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Metabolomics is a recently developed technology for comprehensive analysis of metabolites in organisms. Plant metabolites that are produced for the growth, development, and chemical defense of plants against climatic alterations or natural predators are also useful to us as nutrients or medicines; hence, it is important to comprehend the amounts and varieties of plant metabolites. Besides providing an understanding of the metabolic state in plants under various circumstances, metabolomic techniques are applicable to the clarification of the functions of unknown genes by using natural variants or mutants of the target plants. Furthermore, a metabolomic approach might be useful in the breeding of crops, since valuable plant traits such as taste and yield are closely related to metabolic conditions. Here, we describe the methodology of metabolomics including sample extraction and preparation, metabolite detection, and data processing and analysis, and introduce the application of metabolomic studies to rice.

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Toxicity Studies of Genetically Modified Plants: A Review of the Published Literature

Abstract: According to the information reported by the WHO, the genetically modified (GM)

Cited by 92 publications

References 53 publications

Reduced Fitness of Daphnia magna Fed a Bt-Transgenic Maize Variety

Reduced Fitness of Daphnia magna Fed a Bt-Transgenic Maize Variety

GM Food, Nutrition, Safety, and Health

Rice Metabolomics

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