Toxicity of ZnO and CuO nanoparticles to ciliated protozoa Tetrahymena thermophila

Mortimer, Monika; Kasemets, Kaja; Kahru, Anne

doi:10.1016/j.tox.2009.07.007

Cited by 303 publications

(203 citation statements)

References 55 publications

(81 reference statements)

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“…The lower toxicity of nCuO in freshwater may reflect its slower dissolution at low ionic strengths and Cu + 2 complexation in the presence of organic matter Garner and Keller, 2014;Griffitt et al, 2007;Blinova et al, 2010;Mortimer et al, 2010;Garner et al, 2015;Wang et al, 2011). Other studies indicate that the toxic effect observed from nCuO strongly correlates with the fraction of NP dissolved in aquatic media (Garner and Keller, 2014;Blinova et al, 2010;Aruoja et al, 2009).…”

Section: Aquatic Toxicity Studiesmentioning

confidence: 99%

“…(ECOTOX Database, 2014) Although there are only a few studies on the toxicity of nCu, 48-h LC 50 ranges from 47 μg/L to 419 μg/L for Ceriodaphnia dubia (Gao et al, 2009;Griffitt et al, 2008) and from 700 μg/L to 1500 μg/L for Danio rerio juveniles and adults (Griffitt et al, 2007;Griffitt et al, 2008). For nCuO, 24-h LC 50 ranges from 470 μg/L to 217 mg/L (Manusadžianas et al, 2012;Heinlaan et al, 2008;Blinova et al, 2010;Gallego et al, 2007), while 24-h EC 50 ranges from 30 μg/L to 126 mg/L across several organisms (Blinova et al, 2010;Mortimer et al, 2011;Kasemets et al, 2009;Mortimer et al, 2010;Jo et al, 2012). This information was used to construct species sensitivity distributions (SSDs) for freshwater organisms (Garner et al, 2015).…”

Section: Aquatic Toxicity Studiesmentioning

confidence: 99%

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Comparative environmental fate and toxicity of copper nanomaterials

et al. 2017

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A B S T R A C TGiven increasing use of copper-based nanomaterials, particularly in applications with direct release, it is imperative to understand their human and ecological risks. A comprehensive and systematic approach was used to determine toxicity and fate of several Cu nanoparticles (Cu NPs). When used as pesticides in agriculture, Cu NPs effectively control pests. However, even at low (5-20 mg Cu/plant) doses, there are metabolic effects due to the accumulation of Cu and generation of reactive oxygen species (ROS). Embedded in antifouling paints, Cu NPs are released as dissolved Cu + 2 and in nano-and micron-scale particles. Once released, Cu NPs can rapidly (hours to weeks) oxidize, dissolve, and form CuS and other insoluble Cu compounds, depending on water chemistry (e.g. salinity, alkalinity, organic matter content, presence of sulfide and other complexing ions). More than 95% of Cu released into the environment will enter soil and aquatic sediments, where it may accumulate to potentially toxic levels (> 50-500 μg/L). Toxicity of Cu compounds was generally ranked by high throughput assays as: Cu + 2 > nano Cu(0) > nano Cu(OH) 2 > nano CuO > micron-scale Cu compounds. In addition to ROS generation, Cu NPs can damage DNA plasmids and affect embryo hatching enzymes. Toxic effects are observed at much lower concentrations for aquatic organisms, particularly freshwater daphnids and marine amphipods, than for terrestrial organisms. This knowledge will serve to predict environmental risks, assess impacts, and develop approaches to mitigate harm while promoting beneficial uses of Cu NPs.

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Section: Aquatic Toxicity Studiesmentioning

confidence: 99%

Section: Aquatic Toxicity Studiesmentioning

confidence: 99%

Comparative environmental fate and toxicity of copper nanomaterials

et al. 2017

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“…[1][2][3][4][5] Several kinds of metals and metal oxides posses obvious killing abilities to most microbes even at very low concentrations. 6 Different metal, oxide or salt compounds, mostly based on silver, copper, zinc and magnesium kill microbes by binding to intracellular proteins and inactivating them.…”

Section: Introductionmentioning

confidence: 99%

Anti-Bacterial Activity Studies on Textile Modified With Silver Metal, Copper, Zinc and Magnesium Oxides Nanoparticles

Hamdi¹,

EL-Mekkawi²,

Selim³

et al. 2017

ECB

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Keywords: inorganic antibacterial, antibacterial textile, metal and metal oxide nanoparticle.The anti-bacterial characteristics of different nano-structured metal and metal oxides modified cotton fabrics were investigated. In this study, silver metal, copper, zinc and magnesium oxides have been supported on bleached cotton fabrics. Reduction, wet method, sol gel and precipitation methods were used in the preparation of the antibacterial nanoparticles (NPs). The preparation of the antibacterial-loaded cotton was carried out in-situ and ex-situ by pad dry methods. Formation of the supported nanoparticles was confirmed using x-ray diffraction (XRD), scanning electron microscopy studies (SEM) and energy dispersive x-ray (EDX) analyses. Antibacterial studies on the supported nanoparticles were done on gram positive (Bacillus and S. aureus) and gram negative (E-coli) bacteria by agar diffusion method. The loaded antibacterial nanoparticles are effective against the bacteria under investigation. Under the given experimental conditions, the maximum inactivation performances of each loaded inorganic agent were investigated. The loaded fabrics show the following antibacterial performance order against Bacillus subtilis is Ag=CuO>ZnO>MgO. However, the activity order is CuO>Ag>ZnO=MgO against S.aureus and E. coli. The inactivation performances depend on the type, purity and the amount of antibacterial nanoparticles on the textile surfaces.

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“…nCuO significantly decreases the proportion of unsaturated fatty acids (UFA) while it increases the relative amount of two saturated fatty acids by lowering membrane fluidity and inhibition of de-novo synthesis of fatty acid desaturases in Tetrahymena [18]. In addition, Ag, CuO and ZnO nanoparticle induces toxicity and decreases growth of Tetrahymena [19][20][21]. The aquatic organism, Tetrahymena synthesizes dopamine, noradrenaline and adrenaline at significant level although this organism does not contain adrenal medulla or nervous system [22].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticulat Printex 90 and Titanium Dioxide Stimulate Catecholamine Production in Ciliated Protozoan, Tetrahymena thermophila

2015

Biochem Anal Biochem

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Toxicity of ZnO and CuO nanoparticles to ciliated protozoa Tetrahymena thermophila

Cited by 303 publications

References 55 publications

Comparative environmental fate and toxicity of copper nanomaterials

Comparative environmental fate and toxicity of copper nanomaterials

Anti-Bacterial Activity Studies on Textile Modified With Silver Metal, Copper, Zinc and Magnesium Oxides Nanoparticles

Nanoparticulat Printex 90 and Titanium Dioxide Stimulate Catecholamine Production in Ciliated Protozoan, Tetrahymena thermophila

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