Toxicity of the Sesquiterpene Lactone Parthenin to Cultured Bovine Kidney Cells

Narasimhan, T.R.; Harindranath, N.; Premlata, S.; Murthy, B. S. Kesava; Rao, P. V. Subba

doi:10.1055/s-2007-969454

Cited by 15 publications

(9 citation statements)

References 14 publications

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Section: Discussionsupporting

confidence: 93%

“…The strong correlation between parthenin and cytotoxicity observed in this study is consistent with previous reports [ 15 , 46 , 47 ]. Parthenin itself was highly cytotoxic to bovine kidney cells by inhibiting the synthesis of RNA, DNA and key cellular enzymes within 24 h after exposure [ 47 ]. Similarly, other sesquiterpene lactones including ambrosin, coronopilin, tetraneurin A and hysterone D, and some acetylated pseudoguaianolides have been associated with the cytotoxicity of aerial parts of parthenium weed [ 15 , 48 , 49 ].…”

Section: Discussionsupporting

confidence: 93%

“…Parthenin Phytotoxic [8,10,11,13] Cytotoxic, allergenic [16,23,45,47] Ambrosin Allergenic/dermatitis [16][17][18][19] Coronopilin…”

Section: Sesquiterpene Lactonesmentioning

confidence: 99%

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Toxic Potential and Metabolic Profiling of Two Australian Biotypes of the Invasive Plant Parthenium Weed (Parthenium hysterophorus L.)

Bajwa

Weston

Gurusinghe

et al. 2020

Toxins

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Parthenium weed (Parthenium hysterophorus L.) is an invasive plant species in around 50 countries and a ‘Weed of National Significance’ in Australia. This study investigated the relative toxicity of the leaf, shoot and root extracts of two geographically separate and morphologically distinct biotypes of parthenium weed in Queensland, Australia. Parthenium weed exhibited higher phytotoxic, cytotoxic and photocytotoxic activity in leaf tissue extracts in contrast to shoot and root. The germination and seedling growth of a dicot species (garden cress) were inhibited more than those of a monocot species (annual ryegrass) using a phytotoxicity bioassay. The cytotoxicity of leaf extracts was assessed in a mouse fibroblast cell suspension assay and increased under high ultraviolet A(UV-A) radiation. A major secondary metabolite, parthenin, was found in abundance in leaf extracts and was positively correlated with cytotoxicity but not with photocytotoxicity or phytotoxicity. Ambrosin and chlorogenic acid were also detected and were positively correlated with germination inhibition and the inhibition of radicle elongation, respectively. In addition, other currently unidentified compounds in the leaf extracts were positively correlated with phytotoxicity, cytotoxicity and photocytotoxicity with two to three molecules strongly correlated in each case. Both parthenium weed biotypes investigated did not differ with respect to their relative toxicity, despite their reported differences in invasive potential in the field. This suggests that secondary chemistry plays a limited role in their invasion success.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Toxic Potential and Metabolic Profiling of Two Australian Biotypes of the Invasive Plant Parthenium Weed (Parthenium hysterophorus L.)

Bajwa

Weston

Gurusinghe

et al. 2020

Toxins

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“…The structure of t-DCTN contains three highly reactive functional groups: O = C-C = C (ring A), a lactone (ring C) and cyclopentenone (ring D). Since the structure of t-DCTN is not planar, the most available group is O = C-C = C, which can function as a Michael acceptor to interact with the SH groups of proteins, GSH and nitrogen bases, mainly guanine, through nucleophilic attack [5], [6]. Other diterpenes isolated from C. incanus and Laetia corymbulosa also exhibited cytotoxic effect on several tumor cell lines, and the authors suggested that their effect was due to interaction with macromolecules [7], [8].…”

mentioning

confidence: 99%

Cytotoxic Effect of the Diterpene Lactone Dehydrocrotonin from Croton cajucara on Human Promyelocytic Leukemia Cells

Freire¹,

Melo²,

Aoyama³

et al. 2003

Planta Med

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Diterpenes exhibit potent antineoplastic properties against human and murine carcinoma cell lines. trans-Dehydrocrotonin from Croton cajucara, a Brazilian medicinal plant, is a nor-diterpene with antiulcerogenic activity. In this work, we examined the effect of trans-dehydrocrotonin (t-DCTN) on the vitality of HL60 cells by assessing the MTT reduction, protein content and phosphatase activity of these cells. Protein quantification indicated that t-DCTN reduced the number of cells with an IC50 of 500 microM; mitochondrial function (MTT reduction), was also inhibited (IC50 = 300 microM), when the cells were treated for 24 h. In contrast, when the cells were treated with this lactone in the initial plating and cultured for 96 h, t-DCTN was more toxic for all parameters analyzed: MTT and phosphatase activity (IC50 = 180 microM) and protein content (IC50 = 150 microM). The flavonoid utilized as positive control myricetin and the following IC50 values were obtained after 24 h of treatment: 300 and 192 microM for protein content and MTT reduction, respectively. According to the chemical characteristics of both compounds, the cytotoxic effect of t-DCTN could be explained through two mechanisms: adduct formation with DNA and proteins and/or oxidative stress induction.

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“…goats [297]. Parthenin, a compound characteristic to Parthenium species, inhibited RNA, DNA and protein synthesis in vitro in cultured bovine kidney cells [298]. In a repeated dose toxicity study in rats, the administration of sesquiterpene lactone containing extracts of Smallanthus sonchifolius resulted in alterations of creatinine, glucose and albumin levels, implying renal damage.…”

Section: Toxicological Evaluation Of Common Ragweedmentioning

confidence: 99%

Phytochemical, pharmacological and toxicological studies of alkaloid- and sesquiterpene lactone-containing medicinal plants

Kiss¹

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Toxicity of the Sesquiterpene Lactone Parthenin to Cultured Bovine Kidney Cells

Cited by 15 publications

References 14 publications

Toxic Potential and Metabolic Profiling of Two Australian Biotypes of the Invasive Plant Parthenium Weed (Parthenium hysterophorus L.)

Toxic Potential and Metabolic Profiling of Two Australian Biotypes of the Invasive Plant Parthenium Weed (Parthenium hysterophorus L.)

Cytotoxic Effect of the Diterpene Lactone Dehydrocrotonin from Croton cajucara on Human Promyelocytic Leukemia Cells

Phytochemical, pharmacological and toxicological studies of alkaloid- and sesquiterpene lactone-containing medicinal plants

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