Toxicity of some glucose/mannose-binding lectins to Biomphalaria glabrata and Artemia salina

Santos, Aldenir Feitosa dos; Cavada, Benildo S.; Rocha, B.A.M.; Nascimento, Kyria S.; Santana, Antônio Euzébio Goulart

doi:10.1016/j.biortech.2009.07.062

Cited by 36 publications

(30 citation statements)

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“…Although it is not a natural species, atemoia results from the crossing over of two fruits that belong to genus Annona ; therefore, the presence of acetogenins in its seeds is expected as well as other different compound(s) that could be causing a synergic effect together with acetogenins changing the curve's shape. Caramori studied nutritional value and activity of several enzymes and antinitritional factors in some seeds from Brazilian cerrado fruits, including araticum and ( SANTOS et al, 2007SANTOS et al, , 2010LACHUMY et al, 2010;POUR;SASIDHARAN, 2011;SILVA et al, 2012). Moreover, Artemia salina bioassay proved more accurate and sensitive to detect such compounds than the standard method using mice, previously proposed by the Association of Official Analytical Chemists for food biotoxins analysis (ASSOCIATION…, 1990;PARRA et al, 2001;GARCIA-RODRIGUEZ et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

Assessment of toxic potential of Cerrado fruit seeds using Artemia salina bioassay

et al. 2013

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Section: Resultsmentioning

confidence: 99%

Assessment of toxic potential of Cerrado fruit seeds using Artemia salina bioassay

et al. 2013

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“…Saponins derived from Phytolacca icosandra and Cartunare gam milotica are reported to be active at concentrations of 200 to 25 µg/ml and 26 to 3 µg/ml, respectively [28]. The ethanol extract of the latex from Euphorbia conspicua (Euphorbiaceae) at a concentration of 4.87 µg/ml is reported to kill 90% of adults within 96 h; the ethanol extract from the leaves of Solanum jabrense (Solonaceae) at a concentration of 39.8 µg/ml is reported to kill 90% within at 24 h [29]; and lectins obtained from Dioclea guianensis achieve 100% mortality at 10 µg ml −1 [5]. However, the whole plant extract of Agave filifera , which is rich in flavonoids and steroids [30], is inactive to embryos, likely due to the high molecular weight of their components, which prevents penetration into the gelatinous embryo membrane [31].…”

Section: Discussionmentioning

confidence: 99%

“…After 48 h, the newly hatched larvae were collected and the lethality assay according to procedures described by elsewhere [5]. Groups of 10 (n = 10) larvae were exposed the potassium usnate (0.5; 1, 5; 10 µg/ml) diluted in natural seawater (5 ml) and, after 24 h, the survival rates (%) were recorded.…”

Section: Methodsmentioning

confidence: 99%

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Usnic Acid Potassium Salt: An Alternative for the Control of Biomphalaria glabrata (Say, 1818)

Martins

Silva

et al. 2014

PLoS ONE

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In Brazil, the snail Biomphalaria glabrata is the most important vector of schistosomiasis due to its wide geographical distribution, high infection rate and efficient disease transmission. Among the methods of schistosomiasis control, the World Health Organization recommends the use of synthetic molluscicides, such as niclosamide. However, different substances of natural origin have been tested as alternatives for the control or eradication of mollusks. The literature describes the antitumor, antimicrobial and antiviral properties of usnic acid as well as other important activities of common interest between medicine and the environment. However, usnic acid has a low degree of water solubility, which can be a limiting factor for its use, especially in aquatic environments, since the organic solvents commonly used to solubilize this substance can have toxic effects on aquatic biota. Thus, the aim of the present study was to test the potassium salt of usnic acid (potassium usnate) with regard to molluscicidal activity and toxicity to brine shrimp (Artemia salina). To obtain potassium usnate, usnic acid was extracted with diethyl ether isolated and purified from the lichen Cladonia substellata. Biological assays were performed with embryos and adult snails of B. glabrata exposed for 24 h to the usnate solution solubilized in dechlorinated water at 2.5; 5 and 10 µg/ml for embryos, 0.5; 0.9; 1;5 and 10 µg/ml for mollusks and 0.5; 1; 5; 10 µg/ml for A. salina. The lowest lethal concentration for the embryos and adult snails was 10 and 1 µg/ml, respectively. No toxicity to A. salina was found. The results show that modified usnic acid has increased solubility (100%) without losing its biological activity and may be a viable alternative for the control of B. glabrata.

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“…The Microgramma vacciniifolia rhizome lectin at 100 µ g/mL was able to promote death of Biomphalaria glabrata (intermediate host of S. mansoni ) embryos and adults; in addition, the snails treated with the lectin laid a few number of eggs, among which several showed malformations [111]. The lectins from Cratylia floribunda (CFL) and Dioclea guianensis (Dgui) were also able to promote death of B. glabrata adult snails [112]. Larvicidal activity of lectins from Myracrodruon urundeuva bark, heartwood, and leaves against the mosquito Aedes aegypti (vector of the virus that causes dengue fever, chikungunya, and zika virus fever) was reported [113, 114].…”

Section: Antifungal and Antiparasitic Activities Of Lectinsmentioning

confidence: 99%

Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications

Coelho

Silva

Lima

et al. 2017

Evidence-Based Complementary and Alternative Medicine

148

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Lectins are proteins extensively used in biomedical applications with property to recognize carbohydrates through carbohydrate-binding sites, which identify glycans attached to cell surfaces, glycoconjugates, or free sugars, detecting abnormal cells and biomarkers related to diseases. These lectin abilities promoted interesting results in experimental treatments of immunological diseases, wounds, and cancer. Lectins obtained from virus, microorganisms, algae, animals, and plants were reported as modulators and tool markers in vivo and in vitro; these molecules also play a role in the induction of mitosis and immune responses, contributing for resolution of infections and inflammations. Lectins revealed healing effect through induction of reepithelialization and cicatrization of wounds. Some lectins have been efficient agents against virus, fungi, bacteria, and helminths at low concentrations. Lectin-mediated bioadhesion has been an interesting characteristic for development of drug delivery systems. Lectin histochemistry and lectin-based biosensors are useful to detect transformed tissues and biomarkers related to disease occurrence; antitumor lectins reported are promising for cancer therapy. Here, we address lectins from distinct sources with some biological effect and biotechnological potential in the diagnosis and therapeutic of diseases, highlighting many advances in this growing field.

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Toxicity of some glucose/mannose-binding lectins to Biomphalaria glabrata and Artemia salina

Cited by 36 publications

References 36 publications

Assessment of toxic potential of Cerrado fruit seeds using Artemia salina bioassay

Assessment of toxic potential of Cerrado fruit seeds using Artemia salina bioassay

Usnic Acid Potassium Salt: An Alternative for the Control of Biomphalaria glabrata (Say, 1818)

Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications

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