Toxicity of selected chlorobenzenes to aquatic organisms

Reproductive Impairment in the Zebrafish, Danio rerio, upon Chronic Exposure to 1,2,3-Trichlorobenzene

“…This can lead to more speci"c e!ects of these compounds than the e!ects found upon acute exposure. Calamari et al (1983) established an LC for 123TCB of 3.1 mg/L (95% con"dence limits: 2.3}4.1 mg/L) in the zebra"sh. This value was con"rmed in this laboratory, where an LC of 1.9 mg/L was determined (unpublished results).…”

“…This value was con"rmed in this laboratory, where an LC of 1.9 mg/L was determined (unpublished results). Relating the LC value of Calamari et al (1983) to our EC for reproduction, an acute to chronic ratio (ACR) of 80 can be calculated. This ACR is relatively high for the class of nonpolar narcotics, but also for the other classes.…”

Mode of Action and the Assessment of Chemical Hazards in the Presence of Limited Data: Use of Structure-Activity Relationships (SAR) under TSCA, Section 5

“…In addition, the submitter also tested the cariers in fish acute toxicity tests. The results of these tests were no observed effects at saturation during the fish 14- All of the QSARs, except for the toxicity values for green algae came from Clements et al (10); the algal predictions came from QSAR developed from Calamari et al (49). The fish acute value, which was derived from the QSAR for simple esters (21) and cited in Clements et al (10), exhibit the expected excess toxicity.…”

“…A QSAR is a quantitative relationship between chemical structure and a specific biological effect and is derived using information on a series of related chemicals (11 49 QSARs currently used by EPA/ OTS to predict the toxicity of industrial organic chemicals to aquatic organisms. These QSARs apply to about 40 classes and subclasses of organic chemicals and are grouped into three broad types based on the mode of toxic action: neutral organic chemicals that are assumed to act with a narcotic mechanism; organic chemicals that are assumed to have a more specific mode of toxic action and show excess toxicity in addition to narcosis; and organics that are surface active agents.…”

Remedial Investigation Report. Volume 6: Southern Study Area, Sections 1.0, 2.0, and 3.0 Text, Version 3.3

“…Because chlorobenzene has historically been detected in biota on RMA, there is a potential exposure route through ingestion of lower food chain biota by predators. Chlorobenzene may cause adverse effects at concentrations found in SSA surface waters (Calamari et al, 1983;Birge et al, 1979). The major exposure pathways for terrestrial wildlife for the VHOs are ingestion of surface water and incidental soil ingestion.…”