Abstract:Ribavirin is an antiviral drug showing
high and delayed toxicity
to the destructive agricultural pest Spodoptera litura. Larvae fed with artificial diets containing ribavirin could not
molt successfully and showed abnormal phenotypes, including cuticle
melanization and heavy wrinkle of the newly formed procuticle. RNA-Seq
analysis suggested that ribavirin has great negative influence on
cuticle. Quantitative real-time-polymerase chain reaction results
indicated that ribavirin treatment decreased the expression… Show more
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