Toxicity of Quaternary Mixtures of Phenolic Compounds and Formulated Glyphosate to Microbial Community of River Water

Nweke, Christian Okechukwu; Ike, Christian Chukwuemeka; Ibegbulem, C. O.

doi:10.5132/eec.2016.01.09

Cited by 5 publications

(7 citation statements)

References 39 publications

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“…[12] reported that glyphosate alters the soil texture and microbial diversity by reducing the microbial richness and increasing the population of phytopathogenic fungi. In another study, [13] reported additive interactions of formulated glyphosate with the phenolic compounds. Also, studies have proven that a greater amount of these pesticides do not end up in their intended locations and are dispersed into the ecosystem to non-target organisms through various mechanisms such as run off, erosion deposition by wind, biomagnification, and bioaccumulation [14].…”

Section: Glyphosatementioning

confidence: 99%

Invitro Toxicity of Binary Mixtures of Glyphosate and 2, 2 Dichlorovinyl Dimethyl Phosphate on Bacterial Isolates

Anuniru

Ogbulie

Opurum

et al. 2021

AJOB

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The in vitro toxicity of glyphosate (Gly) and 2, 2 Dichlorovinyl dimethyl phosphate (DDVP) single compound and binary mixtures was assessed against Pseudomonas sp. and Bacillus sp. isolated from Otamiri River, Imo state, Nigeria was investigated. The toxicity response was assessed using the inhibitory effect of the single and binary mixtures on isolates dehydrogenase activity; and 2,3,5 triphenyltetrazolium chloride (TTC) was used as the artificial electron acceptor. The binary mixtures were composed using fixed ratios of glyphosate and 2, 2 Dichlorovinyl dimethyl phosphate in ratios of 20% Gly:80% DDVP, 40% Gly: 60% DDVP, 50% Gly: 50% DDVP, 60% Gly: 40% DDVP and 80% Gly: 20% DDVP. Results obtained showed that the isolates exhibited different degrees of logistic and sigmoidal toxicity trends with areas of hormesis at low concentrations of the toxicants. Furthermore, isobolographic analysis on the toxic interaction of the mixtures presented both synergism and antagonism, based on the relative ratio of the component mixtures. Increasing concentration of glyphosate in the binary mixture caused a shift in the interaction effect from antagonism to synergism. Our findings showed that isolates exhibited tolerance to glyphosate and 2,2 dichlorovinyl dimethyl phosphate and their binary mixtures exposure at concentration range of 0-1000mg/L; above which has deleterious effects on the aquatic organisms. It is evident that there are considerable differences in pesticide sensitivity among the bacterial species and that the presence of glyphosate and 2, 2-dichlorovinyl dimethyl phosphate in the aquatic environment may present toxicological risk to microbial diversity.

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Section: Glyphosatementioning

confidence: 99%

Invitro Toxicity of Binary Mixtures of Glyphosate and 2, 2 Dichlorovinyl Dimethyl Phosphate on Bacterial Isolates

Anuniru

Ogbulie

Opurum

et al. 2021

AJOB

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“…The model was also used to study plant hormesis in response to herbicide application (Zelaya & Owen, 2005;Belz & Cedergreen, 2010). More recently, Nweke et al (2016) used the model to describe herbicide hormesis in microbial community of river water.…”

Section: Limitations Of Brain and Cousens Modelmentioning

confidence: 99%

“…This phenomenon termed 'hormesis' has been observed with all groups of living things for a wide range of endpoints. Hormesis is induced by physical and chemical stressors including phenolic compounds (Boyd et al, 1997;Sinclair et al 1999;Okolo et al 2007;Zaki et al, 2008;Nweke & Okpokwasili, 2010 a, b;Nweke et al, 2014Nweke et al, , 2015, perfluorinated carboxylic acids (Mulkiewicz et al, 2007), mycotoxins (Li et al, 2014;Wang et al, 2014), bacteriocins (Murado & Vázquez, 2010), antibiotics (Welch et al, 1946;Randall et al, 1947, Linares et al, 2006Migliore et al, 2010Migliore et al, , 2013, herbicides (Cedergreen 2008a,b;Cedergreen et al, 2009;Belz & Cedergreen, 2010;Cedergreen & Olesen, 2010;Belz et al, 2011;Belz & Leberle, 2012;Nweke et al, 2016), Wastewater (Hoffmann & Christofi, 2001;Nwanyanwu & Abu 2010), heavy metals (Christofi et al, 2002;Rodea-Palomares et al, 2009;Shen et al, 2009) and ionic liquids (Cho et al, 2007; either as individual or as mixtures. Hormesis was commonly observed in the toxicity test on luminescent bacteria (Christofi et al, 2002;Brack et al, 2003;Fulladosa et al, 2005;Deng et al, 2012;Zhang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Statistical models for biphasic dose-response relationships (hormesis) in toxicological studies

Nweke¹,

Ogbonna²

2024

Ecotoxicol. Environ. Contam.

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The dose-response phenomenon characterized by low dose stimulation and high dose toxicity has been reawakened after a long period of marginalization. This phenomenon termed hormesis is induced by biological, physical and chemical agents and occurs in all groups of living things including whole plants and animals, microorganisms, cells and tissues. Hormesis has attracted increased interest among toxicologists from diverse disciplines, resulting to emergence of new scientific tools for its study. Statistical models have been developed and used to characterize hormesis dose-response relationships. Some of these models include the classical Brain-Cousens model, the Cedergreen-Ritz-Streibig model and their reparameterizations. Other hormesis models are the bilogistic models, their modifications or extensions and the hormesis models used in allelopathy such as An-Johnson-Lovett model. These models are used to describe either U-shaped or inverted U-shaped dose-response relationships and to compute hormesis quantities. This review explored the applications of these models in toxicological studies with emphasis to their strengths and weaknesses.

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“…Triplicate control tubes were prepared for each metal ion, giving a total of 12 controls. The cultures were incubated at room temperature (28 ± 2 o C) for 24 h. The extraction and quantification of TTC-formazan were done as described by Nweke et al (2016).…”

Section: Acute Toxicity Assaymentioning

confidence: 99%

Toxicity of four metals and their mixtures to Pseudomonas fluorescens: An assessment using fixed ratio ray design

Nweke¹,

Ueh²

2018

Ecotoxicol. Environ. Contam.

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The toxicities of binary (Ni(II) + Co(II) and Zn(II) + Cd(II)), ternary (Zn(II) + Cd(II) + Ni(II) and Ni(II) + Co(II) + Cd(II)) and quaternary (Ni(II) + Co(II) + Zn(II) + Cd(II)) mixtures of metal ions to Pseudomonas fluorescens were assessed by using inhibition of dehydrogenase activity as an endpoint. Uniform design concentration ratio (UDCR) and equieffect concentration ratio (EECR) mixtures were designed to evaluate the combined toxicities of these heavy metal ions. All the dose-response relationships of the UDCR and EECR mixtures and the individual metals could be described by logistic function. Toxicities predicted by concentration addition (CA) and independent action (IA) models were compared with the observed toxicities. The CA and IA models predicted similar toxicities of the binary and Zn(II) + Cd(II) + Ni(II) ternary mixtures. Generally, Zn(II) + Cd(II) + Ni(II) ternary mixtures were synergistic while Ni(II) + Co(II) + Cd(II) ternary mixtures were antagonistic. The equieffect and quaternary mixtures were generally synergistic. Synergistic, antagonistic and additive effects of the mixtures are possible from the viewpoint of these analyses.

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Toxicity of Quaternary Mixtures of Phenolic Compounds and Formulated Glyphosate to Microbial Community of River Water

Cited by 5 publications

References 39 publications

Invitro Toxicity of Binary Mixtures of Glyphosate and 2, 2 Dichlorovinyl Dimethyl Phosphate on Bacterial Isolates

Invitro Toxicity of Binary Mixtures of Glyphosate and 2, 2 Dichlorovinyl Dimethyl Phosphate on Bacterial Isolates

Statistical models for biphasic dose-response relationships (hormesis) in toxicological studies

Toxicity of four metals and their mixtures to Pseudomonas fluorescens: An assessment using fixed ratio ray design

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