Toxicity of Pure Hexachlorobenzene and Hcb‐contaminated Pork to Cats

Abstract

Swine were fed a diet containing hexachlorobenzene (HCB) in order to generate contaminated pork which was subsequently cooked and fed to female cats. Feeding the fresh weight equivalent of 50 g cooked pork/day/cat (1 < mg HCB/kg/day) caused marginal weight loss. Oral dosing with 10 mg/kg/day purified HCB resulted in significant weight loss, mild anemia, neutropenia and hepatomegaly. Using the residue of HCB accumulating in the cat adipose tissue as the criterion, the low doses in the pork were absorbed and retained about five times more effectively than the larger oral bolus.

Effect of organic carbon content, clay type, and aging on the oral bioavailability of hexachlorobenzene in rats

“…These results are indicative of less absorption and lower oral bioavailability when compared to the nonaged sediments. Relatively higher retention of the absorbed HCB to tissues was consistent with limited clearance of HCB within 96 h postdosing [28][29][30]. A large Environ.…”

“…These results are indicative of less absorption and lower oral bioavailability when compared to the nonaged sediments. Relatively higher retention of the absorbed HCB to tissues was consistent with limited clearance of HCB within 96 h postdosing [28–30]. A large fraction (38–50%) of the retained radioactivity was associated with the skin of the rats (calculated by dividing 14 C‐HCB in skin with that of the sum of radioactivity in carcass and skin), consistent with its high affinity to fat [28–30].…”

“…Chem. 26,2007 S.A. Saghir et al fraction (38-50%) of the retained radioactivity was associated with the skin of the rats (calculated by dividing 14 C-HCB in skin with that of the sum of radioactivity in carcass and skin), consistent with its high affinity to fat [28][29][30].…”