Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.

Damstra, Terri; Jurgelski, William; Posner, H; Vouk, Vale; Bernheim, Naomi J.; Guthrie, James; Luster, Michael I.; Falk, Henry

doi:10.1289/ehp.8244175

Cited by 32 publications

(6 citation statements)

References 103 publications

(148 reference statements)

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“…25,31 A absorção dos PBBs pelos organismos ocorre de forma rápida e inversamente proporcional ao número de bromos na molécula. 44 Devido a sua característica de lipofilicidade, as maiores concentrações são encontradas, principalmente, nos tecidos hepático e adiposo. 44 Além disso, estudos feitos com humanos mostraram que a transferência placentária ocorre, porém a principal forma de excreção em mamíferos é através do leite.…”

Section: Bifenilas Polibromadas (Pbbs)unclassified

“…44 Devido a sua característica de lipofilicidade, as maiores concentrações são encontradas, principalmente, nos tecidos hepático e adiposo. 44 Além disso, estudos feitos com humanos mostraram que a transferência placentária ocorre, porém a principal forma de excreção em mamíferos é através do leite. 46,47 A meia-vida desses compostos nos organismos é bastante variável, por exemplo, 22 dias em porquinhos--da-índia a 4 anos em macacos.…”

Section: Bifenilas Polibromadas (Pbbs)unclassified

“…36,37,51 Outros estudos feitos ainda mostram relação entre a exposição aos PBBs e incidência de câncer, alteração de crescimento, e alteração no ciclo menstrual. 44,45,52,53 Nos EUA, a produção do HxBB foi descontinuada em 1976, 20 mas a produção do OBB e DBB continuou até 1979. 20,54 Na Grã-Bretanha a produção dos PBBs foi descontinuada em 1977 e na Alemanha em 1985.…”

Section: Bifenilas Polibromadas (Pbbs)unclassified

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Retardantes de chama bromados: uma revisão

Pieroni¹,

Leonel²,

Fillmann³

2016

Quim. Nova

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Section: Bifenilas Polibromadas (Pbbs)unclassified

See 1 more Smart Citation

Retardantes de chama bromados: uma revisão

Pieroni¹,

Leonel²,

Fillmann³

2016

Quim. Nova

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“…(Eyster et al, 1983;Miceli et al, 1985). Animal studies have suggested thyroid, hepatic, reproductive, cancer, and developmental effects after high levels of oral exposure to PBB (Damstra et al, 1982;ATSDR, 2004). In exposed individuals, PBBs are partially metabolized and excreted in feces or stored in fatty tissues where they persist for many years (ATSDR, 2004).…”

Section: Introductionmentioning

confidence: 99%

A decay model for assessing polybrominated biphenyl exposure among women in the Michigan Long-Term PBB Study

Terrell

Manatunga

Small

et al. 2008

J Expo Sci Environ Epidemiol

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The Michigan Long-Term PBB Study was established following exposure to polybrominated biphenyls (PBBs) in the early 1970s. Serum samples from cohort members were analyzed for PBB during 1976-1993. More than 20 years following this industrial incident, some participants still had measurable serum PBB concentration levels. Thus, there is continuing interest in understanding the elimination of PBB from the body. In the present study, we estimated serum PBB decay and investigated the effects of covariates on serum PBB decay rates among 406 female cohort members. We developed a decay model using a general linear mixed model, which attributes unique intercept and slope estimates for each individual while borrowing information across individuals for predicting these quantities. Age at exposure and body mass index (BMI) at the initial measurement were time-independent covariates. Time since exposure, smoking history, pregnancy status, and breast-feeding status were time-dependent covariates. Higher BMI was associated with a slower decay rate; smokers had a faster decay rate than nonsmokers; and increasing age at exposure was marginally associated with a slower decay rate. Our results suggest a faster serum PBB decay rate for women who breast-fed during the interval between serum PBB measurements. To evaluate the predictive performance of our modeling approach, we compared the results from this model with those from a previously developed ordinary least squares (OLS) two-stage decay model. The mixed-effects decay model predicted the observed serum PBB concentration levels significantly better than the OLS two-stage decay model (mixed-effects model, r ¼ 0.93; OLS two-stage model, r ¼ 0.86; Po0.0001).

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“…14 It is possible that exposure to PBB or PCB might modify the local response to HPV infection. Furthermore, PBB exposure has been shown to cause immunosuppression in laboratory animals 15 ; immunosuppression resulting from such conditions as systemic lupus erythematosus 16 and AIDS 17 is associated with an increased risk of cervical dysplasia and cancer. Because of their role as potential endocrine disruptors, PBBs or PCBs might induce dysplastic changes in squamous or glandular cells of the ectocervix or endocervix and might affect the transformation zone where cells are sampled for Pap tests and where cervical cancers arise.…”

mentioning

confidence: 99%

Dietary Exposure to Brominated Flame Retardants and Abnormal Pap Test Results

Jamieson

Terrell²,

Aguocha³

et al. 2011

Journal of Women's Health

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Objective: This study examined a possible association of dietary exposure to polybrominated biphenyls (PBBs), a brominated flame retardant, and self-reported abnormal Pap test results and cervical dysplasia as a precursor to cervical cancer. Methods: Women in Michigan who ingested contaminated poultry, beef, and dairy products in the early 1970s were enrolled in a population-based cohort study in Michigan. Serum PBB and serum polychlorinated biphenyl (PCB) concentrations were measured. Reproductive history and health information, including Pap test results, were self-reported by participants. Results: Of the women, 23% (223 of 956) reported an abnormal Pap test. In unadjusted analyses, self-reporting an abnormal Pap test was associated with younger age, current smoking (hazard ratio [HR] 1.61, 95% confidence interval [CI] 1.19-2.17), and longer duration of lifetime use of oral contraceptives ( ‡ 10 years; HR 1.92, 95% CI 1.21-3.06). When adjusting for PCB exposure, age at the interview, and smoking history, there was a slightly elevated risk of self-reporting an abnormal Pap test among the highly exposed women compared to women with nondetectable PBB concentrations (PBB ‡ 13 lg/L, HR 1.23, 95% CI 0.74-2.06); however, the CI was imprecise. When breastfeeding duration after the initial PBB measurement was taken into account, there was a reduced risk of self-reporting an abnormal Pap test among the highly exposed women who breastfed for ‡ 12 months (HR 0.41, 95% CI 0.06-3.03; referent group: women with nondetectable PBB concentrations who did not breastfeed).

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Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.

Cited by 32 publications

References 103 publications

Retardantes de chama bromados: uma revisão

Retardantes de chama bromados: uma revisão

A decay model for assessing polybrominated biphenyl exposure among women in the Michigan Long-Term PBB Study

Dietary Exposure to Brominated Flame Retardants and Abnormal Pap Test Results

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