Toxicity of Polyalkylcyanoacrylate Nanoparticles II: Doxorubicin-Loaded Nanoparticles

Couvreur, Patrick; Kanté, Boubacar; Grislain, L.; Roland, M; Speiser, P

doi:10.1002/jps.2600710717

Cited by 203 publications

(70 citation statements)

References 7 publications

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“…A quick search in PubMed using the term "intravenous injection and nanoparticles" yielded over 1700 hits, dating as far back as 1982. Surprisingly, the first PubMed report assessing toxicity of doxorubicin loaded on polyisobutylcyanoacrylate nanoparticles following IV infusion in mice was published in the early 1980s (Couvreur et al, 1982). The term "nanoparticle" was used here, rather than the "ultrafine particle" found in the literature of that time.…”

Section: Commentarymentioning

confidence: 99%

Biokinetics of engineered nano-TiO₂ in rats administered by different exposure routes: implications for human health

Bello

Warheit

2017

Nanotoxicology

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Section: Commentarymentioning

confidence: 99%

Biokinetics of engineered nano-TiO₂ in rats administered by different exposure routes: implications for human health

Bello

Warheit

2017

Nanotoxicology

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“…This necessitated further studies into the transition of particle size from microscale to nanoscale [52]. Drug targeting attracted interest in the recent years due to the fact that drugs possess both positive and negative effects on the host cells.…”

Section: The Era Of Nanotechnology In Pharmaceutical Sciencesmentioning

confidence: 99%

“…Furthermore, it must be able to accurately deliver the drug of interest and has also been able to be excreted from the body through normal metabolic pathways. Hence, many materials have presently been studied for application as drug delivery systems with different manufacturing methods and modifications being established, while others are investigated for potential activities against target cells [52].…”

Section: The Era Of Nanotechnology In Pharmaceutical Sciencesmentioning

confidence: 99%

Between the Bioactive Extracts of Edible Mushrooms and Pharmacologically Important Nanoparticles: Need for the Investigation of a Synergistic Combination - A Mini Review

Ukaegbu

Jalal²,

Rashid³

et al. 2017

Asian J Pharm Clin Res

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The pharmacological potential of bioactive compounds extracted from mushrooms has been studied to a reasonable level. In the same vein, the bioactivity of nanoparticles has also been investigated and reported to be of potential pharmacological benefit. No doubt, there is a reasonable amount of claims regarding the vast activity of the mushroom extracts and nanoparticles on the tested cell lines and microorganisms. In this paper, a review of the recent application of bioactive compounds extracted from two edible mushrooms (Coprinus comatus and Lactarius deliciosus), as well as some of the recently reported studies on some nanoparticles of pharmacological potentials, was carried out. In order to check for synergy in the bioactivity of the mushroom extracts when co-administered with nanoparticles, an investigation on the synergistic application of the materials through the encapsulation of the bioactive extracts from the mushroom onto the nanoparticle was proposed. The supposed synergy in the activity of the extract-nanoparticle complex could hold the key to improved activity of nutraceuticals against resistant microorganisms and tumor cells.

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“…Nanoplatforms can decrease the side effects and toxicity related to the administration of anticancer drugs such as doxorubicin in organs that do not need to be treated, (e.g. the heart) [54,55]. Moreover, delivery of a compound by nanoparticles can help prevent its degradation and photobleaching [56].…”

Section: How Can Nanoparticles Improve Drug Delivery?mentioning

confidence: 99%

The role of peptides in blood‐brain barrier nanotechnology

Teixidó

Giralt

2007

Journal of Peptide Science

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Abstract:The blood-brain barrier (BBB) regulates the passage of molecules between the bloodstream and the brain. Overcoming the difficulty of delivery drugs to specific areas of the brain is a major challenge. The BBB exerts a neuroprotective function as it hinders the delivery of diagnostic and therapeutic agents to the brain. Here, we provide an overview of the way in which peptides and nanotechnology are being exploited in tandem to address this problem. Peptides can be used as specialised coatings able to transport nanoparticles with specific properties, such as targeting. The nanoparticle can also carry a peptide drug. Furthermore, peptides can be used in less conventional approaches such as all-peptide nanoparticles. In summary, the combined use of peptides and nanotechnology offers tremendous hope in the treatment of brain disorders.

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Toxicity of Polyalkylcyanoacrylate Nanoparticles II: Doxorubicin-Loaded Nanoparticles

Cited by 203 publications

References 7 publications

Biokinetics of engineered nano-TiO₂ in rats administered by different exposure routes: implications for human health

Biokinetics of engineered nano-TiO₂ in rats administered by different exposure routes: implications for human health

Between the Bioactive Extracts of Edible Mushrooms and Pharmacologically Important Nanoparticles: Need for the Investigation of a Synergistic Combination - A Mini Review

The role of peptides in blood‐brain barrier nanotechnology

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Toxicity of Polyalkylcyanoacrylate Nanoparticles II: Doxorubicin-Loaded Nanoparticles

Cited by 203 publications

References 7 publications

Biokinetics of engineered nano-TiO2 in rats administered by different exposure routes: implications for human health

Biokinetics of engineered nano-TiO2 in rats administered by different exposure routes: implications for human health

Between the Bioactive Extracts of Edible Mushrooms and Pharmacologically Important Nanoparticles: Need for the Investigation of a Synergistic Combination - A Mini Review

The role of peptides in blood‐brain barrier nanotechnology

Contact Info

Product

Resources

About

Biokinetics of engineered nano-TiO₂ in rats administered by different exposure routes: implications for human health

Biokinetics of engineered nano-TiO₂ in rats administered by different exposure routes: implications for human health