Toxicity of poly-dispersed single-walled carbon nanotubes on bone marrow derived Hematopoietic Stem and Progenitor Cells

Mia, Md. Babu; Saxena, Rajiv K.

doi:10.1016/j.crtox.2021.02.003

Cited by 3 publications

(2 citation statements)

References 48 publications

(67 reference statements)

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“…The findings of the study gave some insight for understanding the role of carbon nanotubes in several carcinogenic pathways. Another study investigated the impact of acid-functionalized singlewalled carbon nanotubes (AFSWCNTs) on hematopoietic stem and progenitor cells (HSPCs) in mouse bone marrow because occupational exposures to individuals engaged in commercial CNT uses are probable and this can lead to health risks in the human body [102]. The results highlighted the delivery of AFSWCNTs led to bone marrow atrophy and resulted in the declining total cell recovery, which was reduced by 35% 48 h after treatment.…”

Section: Use Of Bnnts In Biomedical Applicationsmentioning

confidence: 99%

Properties and applications of boron nitride nanotubes

et al. 2022

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Nanomaterials have received increasing attention due to their controllable physical and chemical properties and their improved performance over their bulk structures during the last years. Carbon nanostructures are one of the most widely searched materials for use in different applications ranging from electronic to biomedical because of their exceptional physical and chemical properties. However, BN nanostructures surpassed the attention of the carbon-based nanostructure because of their enhanced thermal and chemical stabilities in addition to structural similarity with the carbon nanomaterials. Among these nanostructures, one dimensional-BN nanostructures are on the verge of development as new materials to fulfill some necessities for different application areas based on their excellent and unique properties including their tunable surface and bandgap, electronic, optical, mechanical, thermal and chemical stability. Synthesis of high quality boron nitride nanotubes (BNNTs) in large quantities with novel techniques provided greater access, and increased their potential use in nanocomposites, biomedical fields and nanodevices as well as hydrogen uptake applications. In this review, properties and applications of one-dimensional BN (1D) nanotubes, nanofibers and nanorods in hydrogen uptake, biomedical field and nanodevices are discussed in depth. Additionally, research on native and modified forms of BNNTs and also their composites with different materials to further improve electronic, optical, structural, mechanical, chemical and biological properties are also reviewed. BNNTs find many applications in different areas, however, they still need to be further studied for improving the synthesis methods and finding new possible future applications.

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Section: Use Of Bnnts In Biomedical Applicationsmentioning

confidence: 99%

Properties and applications of boron nitride nanotubes

et al. 2022

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“…Song et al [18] demonstrated that MWCNT was toxic for bone mesenchymal stem cells in rats. Mia et al [19] found that the acid-functionalized single-walled carbon nanotubes stimulated ROS production on bone marrow-derived hematopoietic stem cells. Mooney et al [20] showed that MWCNT decreased the cell viability of human mesenchymal stem cells.…”

Section: Introductionmentioning

confidence: 99%

Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth

Oliveira¹,

Fayer²,

Zanette³

et al. 2021

Nanotechnology

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Carboxylated multi-wall carbon nanotube (MWCNT-COOH) presents unique properties due to nanoscale dimensions and permits a broad range of applications in different fields, such as bone tissue engineering and regenerative medicine. However, the cytocompatibility of MWCNT-COOH with human stem cells is poorly understood. Thus, studies elucidating how MWCNT-COOH affects human stem cell viability are essential to a safer application of nanotechnologies. Using stem cells from the human exfoliated deciduous teeth model, we have evaluated the effects of MWCNT-COOH on cell viability, oxidative cell stress, and DNA integrity. Results demonstrated that despite the decreased metabolism of mitochondria, MWCNT-COOH had no toxicity against stem cells. Cells maintained viability after MWCNT-COOH exposure. MWCNT-COOH did not alter the superoxide dismutase activity and did not cause genotoxic effects. The present findings are relevant to the potential application of MWCNT-COOH in the tissue engineering and regenerative medicine fields.

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