Toxicity of Pb‐contaminated soil to Japanese quail (<i>C</i><i>oturnix japonica</i>) and the use of the blood–dietary Pb slope in risk assessment

Beyer, W.; Chen, Yu; Henry, Paula F. P.; May, Thomas W.; Mosby, David E.; Rattner, Barnett A.; Shearn-Bochsler, Valerie I.; Sprague, Daniel T.; Weber, John

doi:10.1002/ieam.1453

Cited by 12 publications

(9 citation statements)

References 52 publications

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“…In this assessment, the USEPA utilized the TRAP software program to estimate EC10 values for whole body, muscle, or ovary tissues from a variety of laboratory experiments and preferred these estimates over NOECs and LOECs. In another application, Beyer et al () used BMD analysis to develop an exposure–response relationship between delta‐aminolevulinic acid dehydratase activity and dietary lead exposure to use as an additional line of evidence for ERAs. Thus, BMD analysis has broad applicability for developing risk‐based environmental criteria.…”

Section: Wildlife Bmd Framework Applicationsmentioning

confidence: 99%

“…The BMD approach has generally replaced the use of NOAELs/LOAELs for human health risk assessments, and detailed guidance documents are available (Davis et al ; US Environmental Protection Agency ; Hardy et al ). Although it is not required under most regulatory programs, the BMD approach is now being applied more frequently within ERAs (Sandahl et al ; Sample et al ; Beyer et al ; Mayfield et al ; Rattner et al ). In addition, the US Army uses this approach for the development of TRVs for chemicals of military concern (US Army ; Deck and Johnson ).…”

Section: Introductionmentioning

confidence: 99%

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Benchmark dose analysis framework for developing wildlife toxicity reference values

Mayfield

Skall

2018

Enviro Toxic and Chemistry

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The effects characterization phase of ecological risk assessments (ERAs) often includes the selection or development of toxicity reference values (TRVs) for chemicals under investigation. In wildlife risk assessments, TRVs are thresholds represented by a dose or concentration associated with a specified adverse response. Traditionally, a TRV may be derived from an estimate of the no-observed-adverse effect level or lowest-observed-adverse-effect level, identified from a controlled toxicity study. Because of the limitations of this approach, risk assessors are increasingly developing TRVs using alternative methods. Benchmark dose (BMD) analysis is widely recognized as one approach for developing TRVs. A BMD is derived using the full dose-response relationship from all experimental doses and may represent a user-specified response level (e.g., 5, 10, 20, or 50%). Although many regulatory programs consider the use of BMD-derived wildlife TRVs, there is limited guidance available for implementing the BMD approach, particularly for ERA. The present study provides a framework for ecological risk assessors to identify appropriate data, examine dose-response relationships, estimate BMDs, and document the results for use in risk analysis. This framework demonstrates the process of developing a TRV using BMD analysis and identifies applications for which this approach may enhance ERAs (e.g., site assessment, chemical or pesticide registration programs). Environ Toxicol Chem 2018;37:1496-1508. © 2018 SETAC.

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Section: Wildlife Bmd Framework Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Benchmark dose analysis framework for developing wildlife toxicity reference values

Mayfield

Skall

2018

Enviro Toxic and Chemistry

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“…curve_fit function in Python 3.9.1. The use of a nonlinear model in this context was supported by findings from Pb dosing studies, which indicate a sublinear relationship between blood Pb and dietary Pb, though some avian studies also report a linear blood Pb response to Pb dose . Consequently, the relationship modeled here should be interpreted within the limitations of our soil sampling method.…”

Section: Methodsmentioning

confidence: 99%

House Sparrows as Sentinels of Childhood Lead Exposure

Gillings,

Ton,

Harris

et al. 2024

Environ. Sci. Technol.

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Our understanding of connections between human and animal health has advanced substantially since the canary was introduced as a sentinel of toxic conditions in coal mines. Nonetheless, the development of wildlife sentinels for monitoring human exposure to toxins has been limited. Here, we capitalized on a three-decade long child blood lead monitoring program to demonstrate that the globally ubiquitous and human commensal house sparrow (Passer domesticus) can be used as a sentinel of human health risks in urban environments impacted by lead mining. We showed that sparrows are a viable proxy for the measurement of blood lead levels in children at a neighborhood scale (0.28 km2). In support of the generalizability of this approach, the blood lead relationship established in our focal mining city enabled us to accurately predict elevated blood lead levels in children from another mining city using only sparrows from the second location. Using lead concentrations and lead isotopic compositions from environmental and biological matrices, we identified shared sources and pathways of lead exposure in sparrows and children, with strong links to contamination from local mining emissions. Our findings showed how human commensal species can be used to identify and predict human health risks over time and space.

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“…Blood samples from the quail and portions of the soils and diets were sent to the Columbia Environmental Research Center in Missouri to be analyzed for metals. Samples were analyzed concurrently with samples from a previously published study , which includes details of the methods. Briefly, freeze‐dried blood samples were digested with HNO 3 followed by H 2 O 2 in capped borosilicate test tubes that were heated to 110°C .…”

Section: Methodsmentioning

confidence: 99%

“…The diet adds sorption sites for Pb and decreases the acidity of the digesta. We assumed that the relation of the blood Pb concentration to the concentration of ingested Pb was linear, based on studies on Japanese quail and waterfowl (Figure ) . The relation in mammals, in contrast, is nonlinear , requiring a more involved experimental design.…”

Section: Introductionmentioning

confidence: 99%

Bioaccessibility tests accurately estimate bioavailability of lead to quail

Beyer

Basta

Chaney

et al. 2016

Enviro Toxic and Chemistry

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Hazards of soil-borne lead (Pb) to wild birds may be more accurately quantified if the bioavailability of that Pb is known. To better understand the bioavailability of Pb to birds, the authors measured blood Pb concentrations in Japanese quail (Coturnix japonica) fed diets containing Pb-contaminated soils. Relative bioavailabilities were expressed by comparison with blood Pb concentrations in quail fed a Pb acetate reference diet. Diets containing soil from 5 Pb-contaminated Superfund sites had relative bioavailabilities from 33% to 63%, with a mean of approximately 50%. Treatment of 2 of the soils with phosphorus (P) significantly reduced the bioavailability of Pb. Bioaccessibility of Pb in the test soils was then measured in 6 in vitro tests and regressed on bioavailability: the relative bioavailability leaching procedure at pH 1.5, the same test conducted at pH 2.5, the Ohio State University in vitro gastrointestinal method, the urban soil bioaccessible lead test, the modified physiologically based extraction test, and the waterfowl physiologically based extraction test. All regressions had positive slopes. Based on criteria of slope and coefficient of determination, the relative bioavailability leaching procedure at pH 2.5 and Ohio State University in vitro gastrointestinal tests performed very well. Speciation by X-ray absorption spectroscopy demonstrated that, on average, most of the Pb in the sampled soils was sorbed to minerals (30%), bound to organic matter (24%), or present as Pb sulfate (18%). Additional Pb was associated with P (chloropyromorphite, hydroxypyromorphite, and tertiary Pb phosphate) and with Pb carbonates, leadhillite (a lead sulfate carbonate hydroxide), and Pb sulfide. The formation of chloropyromorphite reduced the bioavailability of Pb, and the amendment of Pb-contaminated soils with P may be a thermodynamically favored means to sequester Pb. Environ Toxicol Chem 2016;35:2311-2319. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America.

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Toxicity of Pb‐contaminated soil to Japanese quail (Coturnix japonica) and the use of the blood–dietary Pb slope in risk assessment

Cited by 12 publications

References 52 publications

Benchmark dose analysis framework for developing wildlife toxicity reference values

Benchmark dose analysis framework for developing wildlife toxicity reference values

House Sparrows as Sentinels of Childhood Lead Exposure

Bioaccessibility tests accurately estimate bioavailability of lead to quail

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