Toxicity of palladium

Liu, Tsan Z.; Lee, Si Duk; Bhatnagar, Rajendra S.

doi:10.1016/0378-4274(79)90113-9

Cited by 124 publications

(48 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pd(II) is a potent enzyme inhibitor, inhibiting creatine kinase, aldolase, succinate dehydrogenase, carbonic anhydrase, alkaline phosphatase, and prolyl hydroxylase (Liu et al 1979). In vitro studies have shown that Pd ions are capable of eliciting a series of cytotoxic effects (Kielhorn et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Biological control of the size and reactivity of catalytic Pd(0) produced by Shewanella oneidensis

Windt

Boon

Bulcke

et al. 2006

Antonie van Leeuwenhoek

124

View full text Add to dashboard Cite

The interaction between Shewanella oneidensis MR-1 and the soluble metal Pd(II) during the reductive precipitation of Pd(0) determined the size and properties of the precipitated Pd(0) nanoparticles. Assessment of cell viability indicated that the bioreduction of Pd(II) was a detoxification mechanism depending on the Pd(II) concentration and on the presence and properties of the electron donor. The addition of H(2) in the headspace allowed S. oneidensis to resist the toxic effects of Pd(II). Interestingly, 25 mM formate was a less effective electron donor for bioreductive detoxification of Pd(II), since there was a 2 log reduction of culturable cells and a 20% decrease of viable cells within 60 min, followed by a slow recovery. When the ratio of Pd:cell dry weight (CDW) was below 5:2 at a concentration of 50 mg l(-1) Pd(II), most of the cells remained viable. These viable cells precipitated Pd(0) crystals over a relatively larger bacterial surface area and had a particle area that was up to 100 times smaller when compared to Pd(0) crystals formed on non-viable biomass (Pd:CDW ratio of 5:2). The relatively large and densely covering Pd(0) crystals on non-viable biomass exhibited high catalytic reactivity towards hydrophobic molecules such as polychlorinated biphenyls, while the smaller and more dispersed nanocrystals on a viable bacterial carrier exhibited high catalytic reactivity towards the reductive degradation of the anionic pollutant perchlorate.

show abstract

Section: Discussionmentioning

confidence: 99%

Biological control of the size and reactivity of catalytic Pd(0) produced by Shewanella oneidensis

Windt

Boon

Bulcke

et al. 2006

Antonie van Leeuwenhoek

124

View full text Add to dashboard Cite

show abstract

“…[3] However, its extensive use has resulted in a rapid increase in the concentration of palladium in the environment, which can lead to serious health hazards. [5] It binds with thiol-containing amino acids (cystine, homocysteine, methionine, glutathione, etc.) [5] It binds with thiol-containing amino acids (cystine, homocysteine, methionine, glutathione, etc.)…”

Section: Introductionmentioning

confidence: 99%

Exclusive Detection of Sub‐Nanomolar Levels of Palladium(II) in Water: An Excellent Probe for Multiple Applications

Kumari

Dey

Kumar

et al. 2014

Chemistry An Asian Journal

View full text Add to dashboard Cite

A new colorimetric probe has been developed for the detection and estimation of Pd(II) at sub-nanomolar concentrations. The probe consisted of rhodamine (signaling unit), which was linked with a bis-picolyl moiety (binding site) through a phenyl ring. Pd(II) induced opening of the spirolactam ring of the probe with the generation of a prominent pink color. The excellent selectivity of the probe towards Pd(II) over Pd(0) or Rh(II) ensured its potential utility for the detection of residual palladium contamination in pharmaceutical drugs and in Pd-catalyzed reactions. The probe showed a "turn-on" (bright yellow) fluorescence upon the addition of Pd(II), which made it suitable for the detection of Pd contaminants in mammalian cells.

show abstract

“…Reactive oxygen species-mediated DNA damage (50) and inhibition of DNA (51-54) and RNA synthesis (55) are important toxic effects of the palladium ion. Moreover, inhibition of the main energetic enzyme in the cell, creatine kinase (CK) (29,30), might reduce the amount of free energy in myocardial cells, which decreases the activity of Ca 2+ ATPase and limits the calcium-binding capacity (56). It appears that palladium inhibits enzymes by binding with SH groups (29), or by substituting Fe 2+ (57).…”

Section: Discussionmentioning

confidence: 99%

“…It appears that palladium inhibits enzymes by binding with SH groups (29), or by substituting Fe 2+ (57). Also, available data indicate that palladium inhibits some other cell enzymes: lactate de hydrogenase (LDH) (58), alkaline phosphatase (30,59), aldolase, carbonic anhydrase (30), etc. These cytotoxic effects of the palladium ion could explain the de pressant effect of palladium compounds on the heart.…”

Section: Discussionmentioning

confidence: 99%

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Peric¹,

Janković²

2013

Journal of Medical Biochemistry

View full text Add to dashboard Cite

SummaryPrevious studies have shown that palladium has toxic effects on the kidney and liver, leads to deterioration of the general condition of animals, and could cause allergy in animals and humans. Considering the limited data about the influence of palladium on the cardiovascular system, the aim of our study was to evaluate the effects of palladium on the heart from available published data, and to compare the toxicity of inorganic and organic palladium compounds. Relevant studies for our review were identified from PubMed and Scopus databases. The search terms included »palladium «, »palladium compound«, »cardiotoxicity«, »toxicity«, »heart«, »myocardium«, »oxidative stress« and »myocardial enzyme«, as well as combinations of these terms. There were only two published studies with the primary purpose to investigate the effect of palladium on the cardiovascular system, while others registered the side-effects of palladium compounds on the heart. Palladium could cause arrhythmias, a drop in blood pressure, decrease of the heart rate, as well as death of experimental animals. Based on the presented data it seems that palladium does not express significant cardiac toxicity when it is bound in an organic compound. Further investigation of the effects of palladium on the heart is necessary for a clear picture of the nature and extent of its cardiac toxicity.

show abstract

Toxicity of palladium

Cited by 124 publications

References 12 publications

Biological control of the size and reactivity of catalytic Pd(0) produced by Shewanella oneidensis

Biological control of the size and reactivity of catalytic Pd(0) produced by Shewanella oneidensis

Exclusive Detection of Sub‐Nanomolar Levels of Palladium(II) in Water: An Excellent Probe for Multiple Applications

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Contact Info

Product

Resources

About