Toxicity of organic solvents toclostridium acetobutylicum for extractive ABE fermentation

Shukla, Rajesh; Kang, Whankoo; Sirkar, Kamalesh K.

doi:10.1007/bf02930835

Cited by 15 publications

(13 citation statements)

References 6 publications

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“…Many authors have studied this problem, and have proposed numerous systems for removing inhibitory products, including gas stripping (Ennis et al 1986), pervaporation (Larrayoz and Puigjaner 1987), solvent extraction Roffler et al 1987Roffler et al , 1988Taya et al 1985;Traxler et al 1985;Wayman and Parekh 1987), perstraction (Shukla et al 1988;Traxler et al 1985), aqueous two-phase systems (Mattiasson et al 1982), critical fluid extraction (de Fil~ ippi and Moses 1982;van Eijs et al 1988), and solid adsorbents (Larsson et al 1984;Maddox 1982;Milestone and Bibby 1981;Nielsen et al 1988). Many authors have studied this problem, and have proposed numerous systems for removing inhibitory products, including gas stripping (Ennis et al 1986), pervaporation (Larrayoz and Puigjaner 1987), solvent extraction Roffler et al 1987Roffler et al , 1988Taya et al 1985;Traxler et al 1985;Wayman and Parekh 1987), perstraction (Shukla et al 1988;Traxler et al 1985), aqueous two-phase systems (Mattiasson et al 1982), critical fluid extraction (de Fil~ ippi and Moses 1982;van Eijs et al 1988), and solid adsorbents (Larsson et al 1984;Maddox 1982;Milestone and Bibby 1981;Nielsen et al 1988).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of solvents for extractive butanol fermentation with Clostridium acetobutylicum and the use of poly(propylene glycol) 1200

Barton

1992

Appl Microbiol Biotechnol

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In an effort to improve the viability of acetone-butanol-ethanol fermentation by extractive fermentation, 63 organic solvents, including alkanes, alcohols, aldehydes, acids, and esters, were experimentally evaluated for biocompatibility with Clostridium acetobutylicum by observing gas evolution from cultures in contact with candidate solvents. Thirty-one of these solvents were further tested to determine their partition coefficient for butanol in fermentation medium. The biocompatible solvent with the highest partition coefficient for butanol (4.8), was poly(propylene glycol) 1200, which was selected for fermentation experiments. This is the highest partition coefficient reported to date for a biocompatible solvent. Extractive fermentations using concentrated feeds were observed to produce up to 58.6 g. 1-1 acetone and butanol in 202 h, the equivalent of three control fermentations in a single run. Product yields (based on total solvent products and glucose consumed) of 0.234 g . g -1 to 0.311 g . g -1 and withinrun solvent productivities of 0.174 g. 1-1. h -1 to 0.290 g. 1-1. h -1 were consistent with conventional fermentations reported in the literature. The extended run-time of the fermentation resulted in an overall improvement in productivity by reducing the fraction of between-run down-time for fermentor cleaning and sterilization.

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Section: Introductionmentioning

confidence: 99%

Evaluation of solvents for extractive butanol fermentation with Clostridium acetobutylicum and the use of poly(propylene glycol) 1200

Barton

1992

Appl Microbiol Biotechnol

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“…Researchers have found that by adding nonionic surfactants, extractive fermentation can promote the secretion of the products, which alleviates the intracellular feedback inhibition and thereby improves the yield . Hence the key to this extractive fermentation approach is to identify suitable extractants that meet the biocompatibility requirements and have strong extractive ability …”

Section: Introductionmentioning

confidence: 99%

Effects of nonionic surfactants on pigment excretion and cell morphology in extractive fermentation of Monascus sp. NJ1

et al. 2018

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“…The distribution coefficients for acetic acid and butyric acid experimentally obtained in this work, are also shown in Table I1 (for experimental procedure, see ref. 23). …”

Section: Resultsmentioning

confidence: 93%

Acetone–butanol–ethanol (ABE) production in a novel hollow fiber fermentor–extractor

Shukla

Kang

Sirkar

1989

Biotech & Bioengineering

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Acetone-butanol-ethanol (ABE) production by immobilized C. acetobutylicum cells is studied in a novel microporous hollow fiber based tubular fermentor-extractor. The solvent 2-ethyl-l-hexanol is used for in situ dispersion-free extraction of products. A mathematical model for simultaneous fermentation and extraction of the products has been investigated. The predicted as well as experimental data follow the same trend. The experimentally observed value of total solvent productivity increased by more than 40% as a result of in situ solvent extraction.

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Toxicity of organic solvents toclostridium acetobutylicum for extractive ABE fermentation

Cited by 15 publications

References 6 publications

Evaluation of solvents for extractive butanol fermentation with Clostridium acetobutylicum and the use of poly(propylene glycol) 1200

Evaluation of solvents for extractive butanol fermentation with Clostridium acetobutylicum and the use of poly(propylene glycol) 1200

Effects of nonionic surfactants on pigment excretion and cell morphology in extractive fermentation of Monascus sp. NJ1

Acetone–butanol–ethanol (ABE) production in a novel hollow fiber fermentor–extractor

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