Toxicity of oral cadmium intake: Impact on gut immunity

Ninkov, Marina; Aleksandrov, Aleksandra Popov; Demenesku, Jelena; Mirkov, Ivana; Mileusnic, Dina; Petrović, Anja; Grigorov, Ilijana; Zolotarevski, Lidija; Tolinački, Maja; Kataranovski, Dragan; Brčeski, Ilija; Kataranovski, Milena

doi:10.1016/j.toxlet.2015.06.002

Cited by 101 publications

(46 citation statements)

References 69 publications

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“…It is nonessential and known to be toxic even at low concentrations [3][4]. Both acute and chronic exposure to Cd results in damage to plants, animals, and humans, including injury to the liver, lungs, testes, renal dysfunction, anemia, osteoporosis, DNA damage, neurodegenerative diseases, intestinal damage, and immunosuppressive and pro-inflammatory effects mainly due to oxidative stress [4][5][6][7][8][9]. Many approaches have been employed to reduce cadmium toxicity, including antioxidant therapy, chelation therapy, and the use of synthetic antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Ameliorative Potential of the Aloe barbadensis Aqueous Fraction on Oxidative Stress Markers and Biochemical Parameters in Cadmium-Intoxicated Rabbits

Hussain

Chaudhry

Anjum

et al. 2016

Pol. J. Environ. Stud.

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This study was conducted to evaluate the possible protective effects of the flavonoid-rich fraction of Aloe barbadensis leaf skin on cadmium (Cd)-induced toxicity in male albino rabbits. Cadmium is a notable environmental pollutant due to its wider range of toxic manifestations. The aqueous fraction of aloe extract (AAF) showed higher phenolics, flavonoids, and antioxidant capacity among other fractions, suggesting its rationale use in this study. Twenty-four rabbits were randomly divided into four groups, including the control group (receiving only vehicle), the Cd group (receiving Cd, 5.1 mg/kg/day), the AAF groups (receiving AAF, 200 mg/Kg/day), and the Cd+AAF group (receiving the same concentrations as the Cd and AAF groups). Oral treatment over a period of 40 days significantly increased (p<0.05) biochemical marker enzymes, including transaminases (AST, ALT), alkaline phosphatase, γ-glutamyl transferase, creatinine, and urea, while total bilirubin (Tb) and albumin were decreased on days 10, 20, 30, and 40 in the Cd group as compared to control. A significant decrease (p<0.05) in enzyme levels and increases in Tb and albumin for Cd+AAF were observed as compared to Cd-treated rabbits. Contents of superoxide dismutase, catalase, and vitamins C and E in liver and kidney tissues were significantly increased (p<0.05), while cadmium content was significantly decreased (p<0.05) for Cd+AAF rabbits as compared to Cd-intoxicated rabbits. Values of all the parameters in only the AAF group were near to control. The histopathological studies for liver and kidney have also supported the Cd+AAF group markedly reducing the toxicity of Cd in both tissues to near normal. Thus, the results suggest that the flavonoid-rich fraction of AAF may

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Section: Introductionmentioning

confidence: 99%

Investigating the Ameliorative Potential of the Aloe barbadensis Aqueous Fraction on Oxidative Stress Markers and Biochemical Parameters in Cadmium-Intoxicated Rabbits

Hussain

Chaudhry

Anjum

et al. 2016

Pol. J. Environ. Stud.

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“…For the general population, food and drinking water are the main sources of Cd exposure due to the biomagnification of Cd within the food chain (4); therefore, the intestinal tract is the first organ that is susceptible to Cd contamination. Early in vitro and animal studies have shown that the intestinal barrier plays a crucial role in limiting Cd absorption (5,6), and Cd exposure causes an inflammatory response, death of epithelial cells, and damage to tight junctions in the intestines, leading to the disruption of the intestinal barrier and the amplification of Cd absorption (6)(7)(8)(9)(10). A recent research study also revealed that subchronic oral Cd exposure significantly affects the gut ecology and susceptibility to colitis in mice (11).…”

mentioning

confidence: 99%

Oral Administration of Probiotics Inhibits Absorption of the Heavy Metal Cadmium by Protecting the Intestinal Barrier

Zhai

Tian

Zhang

et al. 2016

Appl Environ Microbiol

161

105

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The heavy metal cadmium (Cd) is an environmental pollutant that causes adverse health effects in humans and animals. Our previous work demonstrated that oral administration of probiotics can significantly inhibit Cd absorption in the intestines of mice, but further evidence is needed to gain insights into the related protection mode. The goal of this study was to evaluate whether probiotics can inhibit Cd absorption through routes other than the Cd binding, with a focus on gut barrier protection. In the in vitro assay, both the intervention and therapy treatments of

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“…Arsenic accumulation in blood, liver, kidneys, and brain was determined by the atomic absorption spectrometry graphite tube technique [20].…”

Section: Toxicity Testsmentioning

confidence: 99%

Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat

Alahmari¹

2017

AJLS

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Abstract:Arsenic is a significant environmental public health concern. The aim of the present study is to investigate the possible immunotoxic and genotoxic roles of arsenic and the ameliorative effects of quercetin and probiotics as natural antioxidants. This study was performed on male adult Wistar rats divided into six groups: control, NaAsO 2 -treated, quercetintreated, probiotic-treated, NaAsO 2 and quercetin-treated, and NaAsO 2 and probiotics-treated. Blood samples collected from all animals were prepared for some oxidative, immunological and genetic aspects. Administration of arsenic decreased body and spleen weight, reduced serum antioxidant defense parameters and DNA content, increased liver, kidney, and brain weights, plasma malondialdehyde (MDA), myeloperoxidase (MPO), and serum cytokines (IL-1β, IL-6, TNF-α and IFN-γ). Adding quercetin to arsenic was effective in restoring the altered values of cytokines (IL-1β and IL-6), MPO, MDA, catalase (CAT) and reduced glutathione (GSH) induced by arsenic, whereas the presence of probiotics was effective in reducing genotoxicity and improving the changes of cytokines (TNF-α and IFN-γ) and superoxide dismutase (SOD). Quercetin and probiotics are excellent antioxidant therapies, through their ability to suppress reactive oxygen species ROS production, which may contribute to arsenic toxicity.

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Toxicity of oral cadmium intake: Impact on gut immunity

Cited by 101 publications

References 69 publications

Investigating the Ameliorative Potential of the Aloe barbadensis Aqueous Fraction on Oxidative Stress Markers and Biochemical Parameters in Cadmium-Intoxicated Rabbits

Investigating the Ameliorative Potential of the Aloe barbadensis Aqueous Fraction on Oxidative Stress Markers and Biochemical Parameters in Cadmium-Intoxicated Rabbits

Oral Administration of Probiotics Inhibits Absorption of the Heavy Metal Cadmium by Protecting the Intestinal Barrier

Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat

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