Toxicity of nanoparticles of CuO, ZnO and TiO2 to microalgae Pseudokirchneriella subcapitata

Aruoja, Villem; Dubourguier, Henri‐Charles; Kasemets, Kaja; Kahru, Anne

doi:10.1016/j.scitotenv.2008.10.053

Cited by 1,091 publications

(436 citation statements)

References 33 publications

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“…Similarly, Van Hoecke et al [52] found no effects of shading on Pseudokirchneriella subcapitata during experiments with CeO 2 NPs. Aruoja et al [53] reported a similar view for CuO and ZnO NP. In other studies, however, differences have been found [54][55][56], but comparisons are very difficult because of variations in lighting intensity, lamp type, temperature, and shaking conditions used.…”

Section: Critical Variations In Protocols For the Microalgae Testmentioning

confidence: 66%

Ecotoxicity test methods for engineered nanomaterials: Practical experiences and recommendations from the bench

Handy

Cornelis

Fernandes

et al. 2011

Enviro Toxic and Chemistry

295

236

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Abstract-Ecotoxicology research is using many methods for engineered nanomaterials (ENMs), but the collective experience from researchers has not been documented. This paper reports the practical issues for working with ENMs and suggests nano-specific modifications to protocols. The review considers generic practical issues, as well as specific issues for aquatic tests, marine grazers, soil organisms, and bioaccumulation studies. Current procedures for cleaning glassware are adequate, but electrodes are problematic. The maintenance of exposure concentration is challenging, but can be achieved with some ENMs. The need to characterize the media during experiments is identified, but rapid analytical methods are not available to do this. The use of sonication and natural/synthetic dispersants are discussed. Nano-specific biological endpoints may be developed for a tiered monitoring scheme to diagnose ENM exposure or effect. A case study of the algal growth test highlights many small deviations in current regulatory test protocols that are allowed (shaking, lighting, mixing methods), but these should be standardized for ENMs. Invertebrate (Daphnia) tests should account for mechanical toxicity of ENMs. Fish tests should consider semistatic exposure to minimize wastewater and animal husbandry. The inclusion of a benthic test is recommended for the base set of ecotoxicity tests with ENMs. The sensitivity of soil tests needs to be increased for ENMs and shortened for logistics reasons; improvements include using Caenorhabditis elegans, aquatic media, and metabolism endpoints in the plant growth tests. The existing bioaccumulation tests are conceptually flawed and require considerable modification, or a new test, to work for ENMs. Overall, most methodologies need some amendments, and recommendations are made to assist researchers. Environ. Toxicol. Chem. 2012;31:15-31. # 2011 SETAC

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Section: Critical Variations In Protocols For the Microalgae Testmentioning

confidence: 66%

Ecotoxicity test methods for engineered nanomaterials: Practical experiences and recommendations from the bench

Handy

Cornelis

Fernandes

et al. 2011

Enviro Toxic and Chemistry

295

236

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“…NPs (Aruoja et al, 2009;Karlsson et al, 2008;Xu et al, 2009), or one nano-sized particle either alone or versus larger sized counterparts (Liu et al, 2010;Park et al, 2008;Sohaebuddin et al, 2010;Wang et al, 2007). In the present study, we focused on the effects of one type of NP, nano-TiO 2 , with respect to its different physico-chemical properties, including particle surface modification.…”

Section: Most Of the Toxicological Results On Nps Have Been Generatedmentioning

confidence: 99%

In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

Hamzeh

Sunahara

2013

Toxicology in Vitro

115

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/npsi/ctrl?lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?lang=fr Access and use of this website and the material on it are subject to the Terms and Conditions set forth at http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://dx.doi.org/10. 1016/j.tiv.2012.12.018 Toxicology in Vitro, 27, 2, pp. 864-873, 2012-12-28 In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells Hamzeh, Mahsa; Sunahara, Geoffrey I. Therefore, our objective was to investigate the cytotoxicity and genotoxicity of commercially available TiO 2 nanoparticles with respect to their selected physicochemical properties, as well as the role of surface coating of these nanoparticles. While all types of tested TiO 2 samples decrease cell viability in a mass-based concentration-and size-dependent manner, the polyacrylate-coated nano-TiO 2 product was only cytotoxic at higher concentrations. A similar pattern of response was observed for induction of apoptosis/necrosis, and no DNA damage was detected in the polyacrylate-coated nano-TiO 2 model. Given the increasing production of TiO 2 nanoparticles, toxicological studies should take into account the physiochemical properties of these nanoparticles that may help researchers to develop new nanoparticles with minimum toxicity.

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“…Other studies indicate that the toxic effect observed from nCuO strongly correlates with the fraction of NP dissolved in aquatic media (Garner and Keller, 2014;Blinova et al, 2010;Aruoja et al, 2009). In freshwater and marine systems, nCu and nCuO were found to cause some toxicity across a range of toxicological endpoints at concentration < 1 mg/L (Griffitt et al, 2007;Griffitt et al, 2008;Heinlaan et al, 2008;Aruoja et al, 2009;García et al, 2011), while others only found toxicity at greater exposure concentrations (Blinova et al, 2010;Baek and An, 2011).…”

Section: Aquatic Toxicity Studiesmentioning

confidence: 98%

Comparative environmental fate and toxicity of copper nanomaterials

et al. 2017

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A B S T R A C TGiven increasing use of copper-based nanomaterials, particularly in applications with direct release, it is imperative to understand their human and ecological risks. A comprehensive and systematic approach was used to determine toxicity and fate of several Cu nanoparticles (Cu NPs). When used as pesticides in agriculture, Cu NPs effectively control pests. However, even at low (5-20 mg Cu/plant) doses, there are metabolic effects due to the accumulation of Cu and generation of reactive oxygen species (ROS). Embedded in antifouling paints, Cu NPs are released as dissolved Cu + 2 and in nano-and micron-scale particles. Once released, Cu NPs can rapidly (hours to weeks) oxidize, dissolve, and form CuS and other insoluble Cu compounds, depending on water chemistry (e.g. salinity, alkalinity, organic matter content, presence of sulfide and other complexing ions). More than 95% of Cu released into the environment will enter soil and aquatic sediments, where it may accumulate to potentially toxic levels (> 50-500 μg/L). Toxicity of Cu compounds was generally ranked by high throughput assays as: Cu + 2 > nano Cu(0) > nano Cu(OH) 2 > nano CuO > micron-scale Cu compounds. In addition to ROS generation, Cu NPs can damage DNA plasmids and affect embryo hatching enzymes. Toxic effects are observed at much lower concentrations for aquatic organisms, particularly freshwater daphnids and marine amphipods, than for terrestrial organisms. This knowledge will serve to predict environmental risks, assess impacts, and develop approaches to mitigate harm while promoting beneficial uses of Cu NPs.

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Toxicity of nanoparticles of CuO, ZnO and TiO2 to microalgae Pseudokirchneriella subcapitata

Cited by 1,091 publications

References 33 publications

Ecotoxicity test methods for engineered nanomaterials: Practical experiences and recommendations from the bench

Ecotoxicity test methods for engineered nanomaterials: Practical experiences and recommendations from the bench

In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

Comparative environmental fate and toxicity of copper nanomaterials

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