Toxicity of nanomixtures to human macrophages: Joint action of silver and polystyrene nanoparticles

Ilić, Krunoslav; Kalčec, Nikolina; Krce, Lucija; Aviani, Ivica; Turčić, Petra; Pavičić, Ivan; Vrček, Ivana Vinković

doi:10.1016/j.cbi.2022.110225

Cited by 8 publications

(5 citation statements)

References 50 publications

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“…For example, we showed the effects of mixtures on human breast cells, human lymphocytes and human monocytes using in vitro models. 71–73 However, there is no scientific data on the reproductive toxicity of complex mixtures containing different PNP types. Our pioneering effort to provide scientific evidence of combined PNP effects on ER activity as one of the crucial MIEs/KEs involved in AOs that may lead to severe pathogenesis (Table 3) is fundamental for proper risk assessment that should be implemented in the circular economy for the plastic value chain.…”

Section: Resultsmentioning

confidence: 99%

“…For example, we showed the effects of mixtures on human breast cells, human lymphocytes and human monocytes using in vitro models. [71][72][73] However, there is no scientific data on the 3) associated with the agonistic activity of PE-NPs, PP-NPs and PS-NPs (given individually or in mixture) towards the estrogen receptor (ER), where the ER agonistic effect was found to be either a molecular initiating event (MIE) or key event (KE).…”

Section: Aops Related To Agonistic Activity Towards the Ermentioning

confidence: 99%

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Estrogenic activity of plastic nanoparticle mixtures under in vitro settings

Božičević,

Altmann,

Hildebrandt

et al. 2024

Environ. Sci.: Nano

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Section: Resultsmentioning

confidence: 99%

Section: Aops Related To Agonistic Activity Towards the Ermentioning

confidence: 99%

Estrogenic activity of plastic nanoparticle mixtures under in vitro settings

Božičević,

Altmann,

Hildebrandt

et al. 2024

Environ. Sci.: Nano

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“…This synergy between the metallic and organic components in the AgRhNPs system may be associated with their efficient internalization into cells compared to a freely administered extract. Other investigations with the THP-1 monocytic cell line showed no induction of IL-4 production by AgNPs obtained through the reduction of silver nitrate with sodium borohydride [ 85 ]. Furthermore, it was observed that IL-4 production decreased in the lungs of mice that were chronically exposed to AgNPs and had metabolic syndrome [ 86 ].…”

Section: Resultsmentioning

confidence: 99%

Monocyte (THP-1) Response to Silver Nanoparticles Synthesized with Rumex hymenosepalus Root Extract

Alvarez-Cirerol,

Galván-Moroyoqui,

Rodríguez-León

et al. 2024

Nanomaterials

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The study, synthesis, and application of nanomaterials in medicine have grown exponentially in recent years. An example of this is the understanding of how nanomaterials activate or regulate the immune system, particularly macrophages. In this work, nanoparticles were synthesized using Rumex hymenosepalus as a reducing agent (AgRhNPs). According to thermogravimetric analysis, the metal content of nanoparticles is 55.5% by weight. The size of the particles ranges from 5–26 nm, with an average of 11 nm, and they possess an fcc crystalline structure. The presence of extract molecules on the nanomaterial was confirmed by UV-Vis and FTIR. It was found by UPLC-qTOF that the most abundant compounds in Rh extract are flavonols, flavones, isoflavones, chalcones, and anthocyanidins. The viability and apoptosis of the THP-1 cell line were evaluated for AgRhNPs, commercial nanoparticles (AgCNPs), and Rh extract. The results indicate a minimal cytotoxic and apoptotic effect at a concentration of 12.5 μg/mL for both nanoparticles and 25 μg/mL for Rh extract. The interaction of the THP-1 cell line and treatments was used to evaluate the polarization of monocyte subsets in conjunction with an evaluation of CCR2, Tie-2, and Arg-1 expression. The AgRhNPs nanoparticles and Rh extract neither exhibited cytotoxicity in the THP-1 monocyte cell line. Additionally, the treatments mentioned above exhibited anti-inflammatory effects by maintaining the classical monocyte phenotype CD14++CD16, reducing pro-inflammatory interleukin IL-6 production, and increasing IL-4 production.

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“…The latest study showed that the nano mix increased apoptosis and cell death, IL‐6, IL‐8, and TNFα expression, oxidative stress, and mitochondrial dysfunction compared with Ag‐NPs and PS‐NPs treatment alone, indicating that the mixture is an additive effect. Notably, the anti‐inflammatory cytokines IL1‐β, IL‐4, and IL‐10 were not affected by combined exposure compared with single NPs and Ag‐NPs could translocate into the nucleus causing strand DNA breaks 270 . Zhang et al 271 .…”

Section: Toxicological Mechanisms Of Npsmentioning

confidence: 99%

“…Notably, the anti-inflammatory cytokines IL1-β, IL-4, and IL-10 were not affected by combined exposure compared with single NPs and Ag-NPs could translocate into the nucleus causing strand DNA breaks. 270 Zhang et al 271 found that SNPs can activate LC3 and Bax signaling pathways and cause apoptosis in RAW264.7 cells, while melatonin can promote autophagy and inhibit apoptosis caused by SNPs. This is consistent with the study by Ahamed et al 272 that coexposure to SNPs and arsenic can induce mitochondriadependent apoptotic toxicity.…”

Section: Studies Between Nps and Apoptosismentioning

confidence: 99%

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Xuan

Zhao

Skonieczna

et al. 2023

MedComm

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Nanoparticles (NPs) have become one of the most popular objects of scientific study during the past decades. However, despite wealth of study reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding the NPs risk effects. In this review, we first present a comprehensive landscape of the applications of NPs on health, especially addressing the role of NPs in medical diagnosis, therapy. Then, the toxicity of NPs on health systems is introduced. We describe in detail the effects of NPs on various systems, including respiratory, nervous, endocrine, immune, and reproductive systems, and the carcinogenicity of NPs. Furthermore, we unravels the underlying mechanisms of NPs including ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA damage, cell cycle, and epigenetic regulation. In addition, the classical study models such as cell lines and mice and the emerging models such as 3D organoids used for evaluating the toxicity or scientific study are both introduced. Overall, this review presents a critical summary and evaluation of the state of understanding of NPs, giving readers more better understanding of the NPs toxicology to remedy key gaps in knowledge and techniques.

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Toxicity of nanomixtures to human macrophages: Joint action of silver and polystyrene nanoparticles

Cited by 8 publications

References 50 publications

Estrogenic activity of plastic nanoparticle mixtures under in vitro settings

Estrogenic activity of plastic nanoparticle mixtures under in vitro settings

Monocyte (THP-1) Response to Silver Nanoparticles Synthesized with Rumex hymenosepalus Root Extract

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

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