Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action

Jonker, D.; Woutersen, Ruud; Feron, V.J.

doi:10.1016/s0278-6915(97)00077-x

Cited by 54 publications

(27 citation statements)

References 16 publications

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“…However, before applying the results of an interaction study to a particular risk assessment, a risk assessor should also consider the relevance of the conditions and doses used in a study to the exposure scenarios in question. Interactions that occur at high doses may not be manifested at the low environmental contaminant levels that many risk assessments must consider (Jonker et al 1990(Jonker et al , 1993Jonker et al 1996;Seed et al 1995).…”

Section: Taylor Et Al (1995)mentioning

confidence: 99%

Evaluating Chemical Interaction Studies for Mixture Risk Assessment

Borgert

Price

Wells

et al. 2001

Human and Ecological Risk Assessment: An International Journal

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We describe a set of criteria to evaluate the quality of data and interpretations in chemical interaction studies. These criteria reflect the consensus of the literature on interaction analysis developed over decades of research in pharmacology, toxicology, and biometry; address common pitfalls in published interaction studies; and can be easily applied to common methods of interaction analysis. The criteria apply broadly to interaction data for drugs, pesticides, industrial chemicals, food additives, and natural products and are intended to assist risk assessors who must evaluate interaction studies for use in component-based mixture risk assessments. The criteria may also assist researchers interested in conducting interaction studies to inform mixture risk assessment. The criteria are also intended to serve larger scientific goals, including increasing the repeatability of results obtained in chemical interaction studies, enhancing the reliability of conclusions drawn from interaction data, providing greater consistency of interpretations among various analysts, and decreasing uncertainty in using interaction data in risk assessments. We describe the basis for each criterion and demonstrate their utility by using them to evaluate interaction studies from the recent toxicological and pharmacological literature, which serve as examples of different types of data sets that the risk assessor may encounter.

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Section: Taylor Et Al (1995)mentioning

confidence: 99%

Evaluating Chemical Interaction Studies for Mixture Risk Assessment

Borgert

Price

Wells

et al. 2001

Human and Ecological Risk Assessment: An International Journal

View full text Add to dashboard Cite

show abstract

“…This problem becomes even more acute when attempting to predict toxicological interaction DeRosa et al 2004;McCarty and Borgert 2006). Effects of a given chemical at high dose (e.g., enhancing absorption of chemicals across the GI wall, enzyme induction, depletion of antioxidants, and depression of lung clearance) which may increase sensitivity to a second chemical may not occur at sufficiently low doses, and in such cases the combined effect may be the same as if each chemical were present alone (Feron et al 1995;Jonker, Woutersen, and Feron 1996). Thus there is a need to conduct studies at high doses, potentially orders of magnitude greater than typical human exposures, in order to demonstrate test sensitivity as well as at low doses relevant to human exposures to demonstrate relevance of the findings.…”

Section: Importance Of Position On the Dose-response Curvementioning

confidence: 99%

Plausibility of toxicological interaction between lead and methylmercury

Lewandowski

2011

Toxicological & Environmental Chemistry

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“…There is little likelihood that such interactions would occur for the vast majority of man-made chemicals in food because risk characterisation, based on NOAELs and uncertainty factors, aims to ensure that the intake of each individual chemical would be without significant effects. However, in cases where chemicals have the same mode of action on a common target, then concentration addition applies, and effects could be produced, even when the concentrations of each individual chemical is below its no-effect level (Jonker et al, 1996;Tajima et al, 2002), particularly when there may be simultaneous exposure to a large number of chemicals that share a common adverse effect, such as xenoestrogenicity (Rajapakse et al, 2001). Therefore attention needs to be focused during risk characterisation on substances that share a common mode of action.…”

Section: Ways In Which Chemicals May Interactmentioning

confidence: 99%