Toxicity of Metallic Nanoparticles in Microorganisms- a Review

Niazi, Javed H.; Gu, Man Bock

doi:10.1007/978-1-4020-9674-7_12

Cited by 48 publications

(44 citation statements)

References 86 publications

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“…Interestingly, LCMO of 500 mg L −1 showed better antibacterial activity compared to Eu 3+ doped LCMO and LC 50 of LCMO against P. aeruginose, which was higher than other reported nanopartciles. [33][34] It suggests that Eu 3+ doped LCMO is less toxic than LCMO nanoparticle. In LCMO compound the ratio of lanthanum was higher than Eu 3+ doped LCMO because Eu 3+ was doped into the compound by replacing lanthanum ion and decreased the lanthanum ratio.…”

Section: Evaluation Of Antibacterial Propertiesmentioning

confidence: 99%

Antibacterial Effect of Lanthanum Calcium Manganate (La0.67Ca0.33MnO3) Nanoparticles Against Pseudomonas aeruginosa ATCC 27853

De¹,

Mandal²,

Gauri³

et al. 2010

j biomed nanotechnol

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Nanotechnology based water purification system and treatment of human diseases are of higher priority in the immediate future for economic and undetermined health purpose. Nanoparticles offer the possibility of an efficient removal of pollutants and microbes in water treatment. Here we have used colossal magnetoresistance (CMR) materials, lanthanum calcium manganate (LCMO) and Eu 3+ doped lanthanum calcium manganate (LECMO) nanoparticles, to determine the antibacterial efficacy against Pseudomonas aeruginosa-ATCC 27853, a soil and water born pathogenic bacteria. The average size of the synthesized nanoparticles was varied from 50 nm to 200 nm and X-ray diffraction pattern showed the formation of a single phase LCMO or LECMO of an orthorhombic crystal structure after annealing the precursor at 1000 C for 2 h in air. The data revealed that LCMO nanoparticle have higher antibacterial activity compared to LECMO nanoparticle. Thus, LCMO nanoparticles can offer future applications as antimicrobial drug and in water purification technology.

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Section: Evaluation Of Antibacterial Propertiesmentioning

confidence: 99%

Antibacterial Effect of Lanthanum Calcium Manganate (La0.67Ca0.33MnO3) Nanoparticles Against Pseudomonas aeruginosa ATCC 27853

De¹,

Mandal²,

Gauri³

et al. 2010

j biomed nanotechnol

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“…32 In the case of certain metal containing NPs (e.g. Ag, CuO and ZnO) solubilized metal ions have been shown to contribute to their toxicity to bacterial cells.…”

Section: Toxicity To Bacteriamentioning

confidence: 99%

Toxicity of 12 metal-based nanoparticles to algae, bacteria and protozoa

Aruoja

Pokhrel

Sihtmäe

et al. 2015

Environ. Sci.: Nano

160

114

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The use of metal based nanoparticles (NPs) is increasing which leads to their release in water bodies via various waste streams and warrants risk assessment. Consistent biological effect data on NPs for environmentally relevant test species that are accompanied by thorough characterization of NPs are scarce but indispensable for understanding possible risks of NPs. We composed and tested a library of 12 metal-based nanoparticles () using alga Pseudokirchneriella subcapitata, three bacterial species (Vibrio fischeri, Escherichia coli, Staphylococcus aureus) and protozoan Tetrahymena thermophila. The NPs were characterized for physico-chemical properties, solubility and abiotic reactive oxygen species (ROS) production. Also, respective soluble salts were analysed for toxic effects. The algal growth inhibition assay proved the most sensitive and yielded EC 50 values for 10 NPs ranging from 0.1 to 58 mg/l. Algal toxicity correlated with abiotic ROS production of NPs and the majority of NPs formed agglomerates that entrapped algal cells. Despite of different sensitivity, there was a common trend in the toxicity of NPs across different species and test formats: CuO and ZnO had highest toxicity (EC 50 values below 1 mg/l) to all organism groups except protozoa. The high toxicity was mostly due to shedding of toxic concentrations of Zn and Cu ions; for most of the test species Al 2 O 3 , SiO 2 , WO 3 and Sb 2 O 3 were not toxic below 100 mg/l and MgO showed no adverse effect below 100 mg/l to any test species in any test setting. Nano impactThe lack of good quality nanotoxicity data for environmentally relevant test species accompanied by physico-chemical characterization of nanoparticles (NPs) severely hampers risk assessment. This study provides biological response data of a thoroughly characterized library of metal-based NPs using algal, bacterial and protozoan tests. It includes correlations between NP properties and toxicity, as well as results obtained in deionized water, thus eliminating medium-specific effects. Similar trends across species are shown, although algae proved the most sensitive. EC 50 values of 10 NPs ranged from 0.1 to 58 mg/l. The values may be used for toxicity modelling or directly for risk assessment, as the 72 h algal growth inhibition data are mandatory for the registration of chemicals in the European Union.EC 50 -half effective concentration; MBC -Minimal Biocidal Concentration, i.e., the lowest tested nominal concentration of NPs which completely inhibited the formation of visible colonies after sub-culturing on toxicant-free agarised growth medium. Prior subculturing bacteria were incubated with NPs for 24 h at 25 °C in deionised water.

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“…Microorganisms including bacteria, as the decomposers in the food chain, are the primary targets when NPs are released into the environment. Therefore, assessments focussing on the toxic impacts of NPs exposure on microorganisms are imperative (Niazi and Gu, 2009).…”

Section: Introductionmentioning

confidence: 99%