Toxicity of metal-based nanoparticles: Challenges in the nano era

Zhang, Naiding; Xiong, Guiya; Liu, Zhenjie

doi:10.3389/fbioe.2022.1001572

Cited by 86 publications

(46 citation statements)

References 228 publications

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“…Metal-based NPs (such as silver, copper and gold) have drawn attention due to their different properties such as being optically active, having a large surface area, being chemically reactive, as well as mechanically strong. Favorable physicochemical characteristics of metallic nanomaterials led them to be widely used in biomedical applications [ 64 , 65 ]. In order to circumvent vancomycin resistance, a short half-life, and the necessity for a greater dose, Yadav et al [ 66 ] used a nanosized vehicle system for delayed and sustained release of the antibiotic.…”

Section: Novel Therapeutic Agentsmentioning

confidence: 99%

Design and Synthesis of Novel Antimicrobial Agents

Breijyeh

2023

Antibiotics

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The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases has increased as multidrug-resistant bacteria has spread. Due to antibiotics’ availability over the counter in many nations, antibiotic resistance is linked to overuse, abuse, and misuse of these drugs. The World Health Organization (WHO) recognized 12 families of bacteria that present the greatest harm to human health, where options of antibiotic therapy are extremely limited. Therefore, this paper reviews possible new ways for the development of novel classes of antibiotics for which there is no pre-existing resistance in human bacterial pathogens. By utilizing research and technology such as nanotechnology and computational methods (such as in silico and Fragment-based drug design (FBDD)), there has been an improvement in antimicrobial actions and selectivity with target sites. Moreover, there are antibiotic alternatives, such as antimicrobial peptides, essential oils, anti-Quorum sensing agents, darobactins, vitamin B6, bacteriophages, odilorhabdins, 18β-glycyrrhetinic acid, and cannabinoids. Additionally, drug repurposing (such as with ticagrelor, mitomycin C, auranofin, pentamidine, and zidovudine) and synthesis of novel antibacterial agents (including lactones, piperidinol, sugar-based bactericides, isoxazole, carbazole, pyrimidine, and pyrazole derivatives) represent novel approaches to treating infectious diseases. Nonetheless, prodrugs (e.g., siderophores) have recently shown to be an excellent platform to design a new generation of antimicrobial agents with better efficacy against multidrug-resistant bacteria. Ultimately, to combat resistant bacteria and to stop the spread of resistant illnesses, regulations and public education regarding the use of antibiotics in hospitals and the agricultural sector should be combined with research and technological advancements.

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Section: Novel Therapeutic Agentsmentioning

confidence: 99%

Design and Synthesis of Novel Antimicrobial Agents

Breijyeh

2023

Antibiotics

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“…Metal-containing NPs, taken into the body via ingestion, inhalation and skin absorption, cross the blood–brain barrier and reach the brain. The mechanisms of neurotoxicity of metal-containing NPs are related to inflammation, oxidative stress, DNA damage and mitochondrial damage as well as to heavy metals [ 38 , 40 ].…”

Section: Protective Functions Of Mts Against Etiopathogenesis In Pdmentioning

confidence: 99%

Multifunctional Metallothioneins as a Target for Neuroprotection in Parkinson’s Disease

Miyazaki

Asanuma

2023

Antioxidants

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Parkinson’s disease (PD) is characterized by motor symptoms based on a loss of nigrostriatal dopaminergic neurons and by non-motor symptoms which precede motor symptoms. Neurodegeneration accompanied by an accumulation of α-synuclein is thought to propagate from the enteric nervous system to the central nervous system. The pathogenesis in sporadic PD remains unknown. However, many reports indicate various etiological factors, such as oxidative stress, inflammation, α-synuclein toxicity and mitochondrial impairment, drive neurodegeneration. Exposure to heavy metals contributes to these etiopathogenesis and increases the risk of developing PD. Metallothioneins (MTs) are cysteine-rich metal-binding proteins; MTs chelate metals and inhibit metal-induced oxidative stress, inflammation and mitochondrial dysfunction. In addition, MTs possess antioxidative properties by scavenging free radicals and exert anti-inflammatory effects by suppression of microglial activation. Furthermore, MTs recently received attention as a potential target for attenuating metal-induced α-synuclein aggregation. In this article, we summarize MTs expression in the central and enteric nervous system, and review protective functions of MTs against etiopathogenesis in PD. We also discuss neuroprotective strategies for the prevention of central dopaminergic and enteric neurodegeneration by targeting MTs. This review highlights multifunctional MTs as a target for the development of disease-modifying drugs for PD.

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“…8−11 As a result, there has been enhanced scrutiny on the safety and regulation of nanosilver and similar antimicrobial nanoparticles (NPs). [4][5][6]12,13 Silver nanoparticles (AgNPs) are produced in a variety of ways, including chemical synthesis, milling, ablation, and even biosynthesis using plants or pathogens. 14−20 Each method leads to different surface chemistry, emissivity, stability, and purity, resulting in different efficacy and toxicity.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Silver has been known for its antibacterial qualities for centuries. , Over the last few decades, nanosilver has experienced increasing interest as a functional material additive, with the number of studies and publications steadily rising. Countless products have incorporated nanosilver and other engineered nanomaterials − that exhibit antimicrobial activity. Studies show that antimicrobial activity is typically due to ion emission or reactive oxygen species, which are toxic to nonpathogenic organisms. − As a result, there has been enhanced scrutiny on the safety and regulation of nanosilver and similar antimicrobial nanoparticles (NPs). − ,, …”

Section: Introductionmentioning

confidence: 99%

EVQ-218: Characterization of High-Energy Nanoparticles that Measure up to NIST Standards

Kennon,

Niedermeyer

2024

ACS Omega

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EVQ-218 is a high-energy produced nanoparticle (NP) with a method of manufacture that avoids chemical or biological synthesis. The patented single-step process generates stable, pure metal NPs directly into HPLC grade water. Laser ablation via the multiple cross laser system occurs at a rate that is in the region of dielectric breakdown, generating temperatures and pressures akin to those of diamond formation. The spherical particles from this method have an ultrastable shell structure that inhibits the hallmark ion emission that occurs in other nanosilver species. The resulting particle size distribution is so narrow that additional size refinement or stabilizing chemistries are not necessary. These properties make EVQ-218 an attractive clean and green alternative to traditional nanosilvers, particularly when factoring in shelf life, as EVQ-218 maintains (uniform) stability for years, while NIST standard materials degrade within a few weeks. EVQ-218 characterization and differentiation are timely as the rise of antimicrobial resistance has caused a surge of research on antimicrobial silver NPs. It has been widely established that the antimicrobial activity of nanosilver is due to ion emission. Unfortunately, metal ions can be quite toxic and prevent certain biomedical and consumer product applications. In an ever-changing regulatory landscape, there is increasing scrutiny to definitively characterize nanomaterials and assess their potential environmental/toxicological footprint. EVQ-218 was characterized alongside comparable NIST standard NPs, with particular interest in speciation and fate. Particle characterization studies reveal that EVQ-218 is nearly equivalent to NIST standard material with respect to particle morphology and uniformity. Dissolution and surface chemistry studies quickly differentiate EVQ-218 as the first stable, nonemissive, pure metal NP that is on par with NIST standards for ideal materials.

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Toxicity of metal-based nanoparticles: Challenges in the nano era

Cited by 86 publications

References 228 publications

Design and Synthesis of Novel Antimicrobial Agents

Design and Synthesis of Novel Antimicrobial Agents

Multifunctional Metallothioneins as a Target for Neuroprotection in Parkinson’s Disease

EVQ-218: Characterization of High-Energy Nanoparticles that Measure up to NIST Standards

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