Toxicity of lead acetate to female rabbits after chronic subcutaneous administration. 1. Biochemical and clinical effects

Falke, H.E.; Zwennis, Willem C. M.

doi:10.1007/bf01971830

Cited by 28 publications

(10 citation statements)

References 17 publications

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“…Also, tissue hypoxia is a possible mechanism for high production of RBCs in moderate lead poisoning. MCV and MCH levels were decreased after lead intoxication in our study that it was in agreement with several studies (Noori et al;Falke & Zwennis, 1990;Antonowicz et al, 1991).…”

Section: Discussionsupporting

confidence: 94%

Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats

Golalipour

Roshandel

et al. 2007

Int. J. Morphol.

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SUMMARY:Lead is one of the most important environmental pollution which is toxic to many organ systems. D-penicillamine (D-P) is a chelator drug which is used for treatment of lead toxicity for several years. This study was conducted in order to evaluate the efficacy of D-P in reducing the effects of lead on hematological indices. This study was done on 36 male adult, 6-8 weeks albino Wistar rats in Gorgan University of Medical Sciences. At first male adult rats were exposed to lead acetate in their drinking water. After 8 weeks, 6 rats were selected and blood samples were prepared to assess the effects of lead toxicity. The remained lead exposed rats were divided into recovery and treatment groups where distilled water and D-P was administered for them, respectively. After lead exposure, red blood cell count increased slightly, but hemoglobin and hematocrite were decreased. Also MCV and MCH were significantly decreased (P<0.05). RDW, PDW and MPV were significantly higher in lead exposed rats (P<0.05). After recovery period, most of parameters were close to normal while there were no significant differences between recovery and treatment groups. This study showed that hematologic effects of lead are reversible and D-P administration do not play an important role in subchronic lead intoxication.

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Section: Discussionsupporting

confidence: 94%

Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats

Golalipour

Roshandel

et al. 2007

Int. J. Morphol.

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“…These results agreed with studies conducted by Shehata () who found that the final body weight, daily body gain and FI were decreased in rabbits exposed to 0.5% lead acetate in the diet of growing rabbit. Additionally, Falke and Zwennis () reported that addition of lead at dose of 0.8–1.20 μg/kg body weight three times a week, decrease the body weight of female rabbit.…”

Section: Resultsmentioning

confidence: 99%

Growth performance, biochemical, cytological and molecular aspects of rabbits exposed to lead toxicity

Taha

Abdelnour

Alagawany

2019

Animal Physiology Nutrition

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Heavy metals have enormous variety of deleterious effects on many organs in the body. This study demonstrated the toxic influences of lead on the growth, biochemical, cellular and molecular aspects of developing rabbits. Seventy‐five rabbits (New Zealand NZW) were divided into five equal groups as follows; control (C) and four treatment groups (T1‐4) orally administered lead acetate solution as follow T1: 20, T2: 30, T3: 50 and T4: 70 mg/kg body weight. Lead resulted in a significant decrease in live body weight, daily body weight gain and feed intake in T3 and T4 compared to those in other groups. Blood haematology measurements such as red blood cells, haematocrit (HCT), mean corpuscular volume, platelet, white blood cells and lymphocytes were significantly influenced by the high level of lead. Oral administration of lead significantly reduced total proteins in the serum. It was observed that the high lead level led to significantly (p < 0.05) increased levels of aspartate aminotransferase, alanine aminotransferase enzymes, urea and creatinine. Four random amplified polymorphic DNA primers polymorphism were detected among the treatment groups. Total number of induced bands (loss or appearance) compared with control group were 4, 10, 10 and 14 bands using primers P1, P2, P3 and P4 respectively. Number of micronuclei showed a dose–response increase and the difference was highly significant especially between control compared with T3 and T4 groups. From our results, we can conclude that exposure of rabbits to lead acetate resulted in negative effects on the growth performance and altered the haematological and biochemical parameters, in addition to its adverse impact on cytological and molecular characterization of animals.

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“…[24][25][26][27][28][29] Hg, 30,31) Pb, [30][31][32][33][34] Be 35) and Ni 7) are also able to reduce the hepatic enzyme activities. Based on those findings and our new results, the organ specificities shown by liver and lung in the susceptibilities of drug-metabolizing enzymes to several heavy metals were attributable partly, if not entirely, to the organ specific nature of enzymes.…”

Section: Fig 5 In Vitro Effects Of Heavy Metals On the Udp-glucuronylmentioning

confidence: 99%

Comparative Study on in vitro Inhibitory Effects of Heavy Metals on Rabbit Drug-Metabolizing Enzymes.

Nakahama

Inouye

Fukuhara³

2001

JOURNAL OF HEALTH SCIENCE

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The in vitro inhibitory effects of heavy metals, i.e., mercury, cadmium, lead, nickel and beryllium in their chloride forms, on rabbit pulmonary drug-metabolizing enzymes were studied comparatively. Microsomal and cytosolic fractions prepared from rabbit lungs were incubated in the presence of heavy metals prior to enzyme assays. Mercury was the most potent in reducing cytochrome P450 content and mixed-function oxidase activities including NADPH-cytochrome c reductase and benzo[a]pyrene hydroxylase. The addition of mercury to pulmonary microsomal preparations resulted in a spectral shift from 450 nm to 420 nm in an absorption maximum of cytochrome P450-carbon monoxide complex with mercury chloride being more potent than methylmercury. Cadmium was also inhibitory, while the effects of nickel were noted only at higher concentrations. Neither lead nor beryllium was inhibitory. Among second-phase drug-metabolizing enzymes, UDP-glucuronyltransferase and glutathione S-transferase were found to be susceptible to the adverse effects of mercury and lead, respectively. The extent of inhibition of the latter activity by mercury were highly dependent on the concentration of glutathione, implying the complex formation between them. Cadmium was slightly inhibitory to both enzyme activities, though the other metals had no effect. The results indicate that the pulmonary toxicities of airborne heavy metals could be inferred using simple in vitro assays.

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Toxicity of lead acetate to female rabbits after chronic subcutaneous administration. 1. Biochemical and clinical effects

Cited by 28 publications

References 17 publications

Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats

Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats

Growth performance, biochemical, cytological and molecular aspects of rabbits exposed to lead toxicity

Comparative Study on in vitro Inhibitory Effects of Heavy Metals on Rabbit Drug-Metabolizing Enzymes.

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