Toxicity of imidazoles ionic liquid [C16mim]Cl to Hela cells

Xia, Xiaohua; Wan, Rui; Wang, Peijin; Huo, Weiran; Dong, Hui; Du, Qiyun

doi:10.1016/j.ecoenv.2018.07.022

Cited by 33 publications

(16 citation statements)

References 46 publications

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“…All ILs were tested for their cytotoxicity. As stated above, three different human cancer cell lines were chosen as the prototype of human cells, namely, HeLa, HCT-116, and MCF-7, derived from cervical, colon, and breast cancer lines, respectively, and previously used to test IL cytotoxicity. − Cancer cells are generally more susceptible to toxicity than normal cells because they have a highly unstable genetic load and undergo rapid cell divisions …”

Section: Resultsmentioning

confidence: 99%

When Functionalization Becomes Useful: Ionic Liquids with a “Sweet” Appended Moiety Demonstrate Drastically Reduced Toxicological Effects

Billeci

D’Anna

Feroci

et al. 2019

ACS Sustainable Chem. Eng.

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The growing number of applications of ionic liquids (ILs) in industry have brought attention to the green credentials of synthesis, as well as their cyto-and ecotoxicities both for their use and accidental leakage into the environment. With the above in mind, we designed a class of ILs with either cations bearing gluconamide motif and aliphatic side chains or the anion incorporating gluconic acid (derived from food waste) moiety. An ionic liquid with imidazolium cation with an appended gluconic amide (bearing 5 hydroxyl groups) moiety was also synthesised for a useful comparison. Different structural features were considered, placing emphasis on the nature and length of the alkyl chain and the nature of the anion. For comparison, two ILs with one hydroxyl group and another without any hydroxyl-groups were prepared.

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Section: Resultsmentioning

confidence: 99%

When Functionalization Becomes Useful: Ionic Liquids with a “Sweet” Appended Moiety Demonstrate Drastically Reduced Toxicological Effects

Billeci

D’Anna

Feroci

et al. 2019

ACS Sustainable Chem. Eng.

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“…Among the analyzed cell lines, HeLa ,,− and HepG2 − were the most investigated, in relation to ILs. HeLa cells represent prototypical cells of the human epithelium.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Anticancer and Antivirus Activities of Cyano- and Bis(Trifluoromethylsulfonyl)imide-Based Ionic Liquids

Musiał

Olejniczak

Denel-Bobrowska

et al. 2021

ACS Sustainable Chem. Eng.

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In the current work, we present a broad analysis of cytotoxicity toward normal (kidney and lung) and cancer (lung, liver, and cervix) cells of ionic liquids (ILs) with imidazolium cations and cyano-based or bis(trifluoromethylsulfonyl)imide anions. Additionally, we verify if ILs might be candidates for new potential virucidal agents. We observed the highest biological activity for 1-methyl-3-octylimidazolium bis(trifluoromethylsulfonyl)imide, whereas the least toxic was 1-ethyl-3-methylimidazolium thiocyanate. We found that all investigated ILs revealed a lack of antiviral activity against viruses: human parainfluenza virus type 3 (HPIV-3), human adenovirus 5 (AdV5), human herpesvirus 1 (HSV-1), and human herpesvirus 5 (HCMV) in nontoxic concentrations.

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“…A number of recent studies have used a similar approach to examine cell death mode of other cell types following treatment with imidazoliumbased ILs. Apoptosis was shown to contribute to cell death in both hepatocellular carcinoma (HepG2) cells and human cervical carcinoma (Hela) cells, following treatment with [C12MIM]Cl and [C16MIM]Cl (Wan et al, 2018;Wang et al, 2020;Xia et al, 2018). In work by [C8MIM]Br induced apoptosis in rat phaeochromocytoma (PC12) cells, triggered by excessive reactive oxygen species (ROS) and mediated by mitochondrial depolarization and permeability transition (Li et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Characterization of ionic liquid cytotoxicity mechanisms in human keratinocytes compared with conventional biocides

et al. 2021

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Toxicity of imidazoles ionic liquid [C16mim]Cl to Hela cells

Cited by 33 publications

References 46 publications

When Functionalization Becomes Useful: Ionic Liquids with a “Sweet” Appended Moiety Demonstrate Drastically Reduced Toxicological Effects

When Functionalization Becomes Useful: Ionic Liquids with a “Sweet” Appended Moiety Demonstrate Drastically Reduced Toxicological Effects

In Vitro Anticancer and Antivirus Activities of Cyano- and Bis(Trifluoromethylsulfonyl)imide-Based Ionic Liquids

Characterization of ionic liquid cytotoxicity mechanisms in human keratinocytes compared with conventional biocides

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