Toxicity of graphene oxide to white moss Leucobryum glaucum

Lin, Xiaowei; Chen, Lingyun; Xiu, Hu; Feng, Shicheng; Liu, Huang; Quan, Guoping; Xue, Wei; Yang, Shengnan

doi:10.1039/c7ra10096e

Cited by 17 publications

(9 citation statements)

References 46 publications

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“…Our results were consistent with the results in which low concentrations of GO increased plant root length, but in which high concentrations inhibited plant growth. Overall, the results indicated that the response of plants to nanomaterials depends on the plant genotype; content of endogenous phytohormone content; and the concentration, structure and localization of the nanomaterials within the plant [13,17].…”

Section: Plant Responses To Nanomaterials Depends On Multiple Factorsmentioning

confidence: 93%

“…As an exogenously applied material with unique properties, GO can regulate the growth and development of plants either directly or indirectly. The accumulation of nanomaterials in plants has been shown to increase the shoot length, chlorophyll b content, number of adventitious roots, and fresh root weight of rice seedlings [13]. A 500 mg/kg CeO 2 treatment was shown to increase the plant height, chlorophyll content, and biomass of barley without any toxic effects [14].…”

Section: Plant Responses To Nanomaterials Depends On Multiple Factorsmentioning

confidence: 99%

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Graphene oxide and indole-3-acetic acid cotreatment regulates the root growth of Brassica napus L. via multiple phytohormone pathways

Xie

Fan

et al. 2020

BMC Plant Biol

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Background: Studies have indicated that graphene oxide (GO) could regulated Brassica napus L. root growth via abscisic acid (ABA) and indole-3-acetic acid (IAA). To study the mechanism and interaction between GO and IAA further, B. napus L (Zhongshuang No. 9) seedlings were treated with GO and IAA accordance with a two factor completely randomized design. Results: GO and IAA cotreatment significantly regulated the root length, number of adventitious roots, and contents of IAA, cytokinin (CTK) and ABA. Treatment with 25 mg/L GO alone or IAA (> 0.5 mg/L) inhibited root development. IAA cotreatment enhanced the inhibitory role of GO, and the inhibition was strengthened with increased in IAA concentration. GO treatments caused oxidative stress in the plants. The ABA and CTK contents decreased; however, the IAA and gibberellin (GA) contents first increased but then decreased with increasing IAA concentration when IAA was combined with GO compared with GO alone. The 9-cis-epoxycarotenoid dioxygenase (NCED) transcript level strongly increased when the plants were treated with GO. However, the NCED transcript level and ABA concentration gradually decreased with increasing IAA concentration under GO and IAA cotreatment. GO treatments decreased the transcript abundance of steroid 5-alpha-reductase (DET2) and isochorismate synthase 1 (ICS), which are associated with brassinolide (BR) and salicylic acid (SA) biosynthesis, but increased the transcript abundance of brassinosteroid insensitive 1-associated receptor kinase 1 (BAK1), cam-binding protein 60-like G (CBP60) and calmodulin binding protein-like protein 1, which are associated with BR and SA biosynthesis. Last, GO treatment increased the transcript abundance of 1-aminocyclopropane-1-carboxylic acid synthase 2 (ACS2), which is associated with the ethylene (ETH) pathway.(Continued on next page) Conclusions: Treatment with 25 mg/L GO or IAA (> 0.5 mg/L) inhibited root development. However, IAA and GO cotreatment enhanced the inhibitory role of GO, and this inhibition was strengthened with increased IAA concentration. IAA is a key factor in the response of B. napus L to GO and the responses of B. napus to GO and IAA cotreatment involved in multiple pathways, including those involving ABA, IAA, GA, CTK, BR, SA. Specifically, GO and IAA cotreatment affected the GA content in the modulation of B. napus root growth.

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Section: Plant Responses To Nanomaterials Depends On Multiple Factorsmentioning

confidence: 93%

Section: Plant Responses To Nanomaterials Depends On Multiple Factorsmentioning

confidence: 99%

Graphene oxide and indole-3-acetic acid cotreatment regulates the root growth of Brassica napus L. via multiple phytohormone pathways

Xie

Fan

et al. 2020

BMC Plant Biol

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“…First, oxidative damage was the widely reported toxicological mechanism of nanomaterials. 16,42,43 The literature also conrmed that Ag NPs induced oxidative stress to white-rot fungi. 25,26 Second, the high strength of RGO might induce physical damage to P. chrysosporium, similar to that observed in case of CNTs; CNTs have been reported to penetrate the bacterial membrane as a dart.…”

Section: Discussionmentioning

confidence: 99%

Influence of reduced graphene oxide on the growth, structure and decomposition activity of white-rot fungus Phanerochaete chrysosporium

Feng

et al. 2018

RSC Adv.

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Graphene materials have attracted great interest nowadays due to their large-scale production and wide applications. It is urgent to evaluate the ecological and environmental risk of graphene materials for the healthy development of the graphene industry. Herein, we evaluated the influence of reduced graphene oxide (RGO) on the growth, structure and decomposition activity of white-rot fungus, whose decomposition function is vital for carbon cycle. RGO slightly stimulated the fresh weight and dry weight gains of Phanerochaete chrysosporium. A larger number of fibrous structures were observed at low RGO concentrations in P. chrysosporium, which was consistent with the elongation of cells observed under a transmission electron microscope. RGO did not affect the chemical composition of P. chrysosporium.Moreover, the laccase production of P. chrysosporium was not influenced by RGO. The degradation activities of P. chrysosporium for dye and wood appeared to be promoted slightly, but the differences were insignificant compared to the control. Therefore, RGO had low toxicity to white-rot fungus and was relatively safe for the carbon cycle.

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“…GO exposure has been demonstrated to induce cell wall destruction in white moss L. glaucum and human stem cells [ 56 , 57 ], as well as cell membrane damage in green algae R. subcapitata and mussel M. galloprovincialis [ 5 , 58 ]. Our protein expression analysis reveals that the expression of a plasma membrane protein with a role in cell wall integrity, PUN1, was upregulated, suggesting that the cell wall might be one of the target sites upon untreated GO exposure.…”

Section: Discussionmentioning

confidence: 99%

Dependence of Graphene Oxide (GO) Toxicity on Oxidation Level, Elemental Composition, and Size

Jiang

Amadei

Lin

et al. 2021

IJMS

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The mass production of graphene oxide (GO) unavoidably elevates the chance of human exposure, as well as the possibility of release into the environment with high stability, raising public concern as to its potential toxicological risks and the implications for humans and ecosystems. Therefore, a thorough assessment of GO toxicity, including its potential reliance on key physicochemical factors, which is lacking in the literature, is of high significance and importance. In this study, GO toxicity, and its dependence on oxidation level, elemental composition, and size, were comprehensively assessed. A newly established quantitative toxicogenomic-based toxicity testing approach, combined with conventional phenotypic bioassays, were employed. The toxicogenomic assay utilized a GFP-fused yeast reporter library covering key cellular toxicity pathways. The results reveal that, indeed, the elemental composition and size do exert impacts on GO toxicity, while the oxidation level exhibits no significant effects. The UV-treated GO, with significantly higher carbon-carbon groups and carboxyl groups, showed a higher toxicity level, especially in the protein and chemical stress categories. With the decrease in size, the toxicity level of the sonicated GOs tended to increase. It is proposed that the covering and subsequent internalization of GO sheets might be the main mode of action in yeast cells.

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Toxicity of graphene oxide to white moss Leucobryum glaucum

Abstract: Graphene oxide was toxic to white moss Leucobryum glaucum.

Cited by 17 publications

References 46 publications

Graphene oxide and indole-3-acetic acid cotreatment regulates the root growth of Brassica napus L. via multiple phytohormone pathways

Graphene oxide and indole-3-acetic acid cotreatment regulates the root growth of Brassica napus L. via multiple phytohormone pathways

Influence of reduced graphene oxide on the growth, structure and decomposition activity of white-rot fungus Phanerochaete chrysosporium

Dependence of Graphene Oxide (GO) Toxicity on Oxidation Level, Elemental Composition, and Size

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