Toxicity of Gossypol at Antifertility Dosages in Male Rats: Statistical Analysis of Lethal Rates and Body Weight Responses

Weinbauer, Gerhard F.; Rovan, E.; Frick, J.

doi:10.1111/j.1439-0272.1983.tb00361.x

Cited by 25 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research findings have also shown that there are marked differences in species susceptibility to gossypol toxicity (Weinbauer et al 1983). Our preliminary studies revealed antifertility effects of bait containing 5% crude cottonseed oil (CCSO) in one third of male B. bengalensis fed for 7 days .…”

Section: Introductionmentioning

confidence: 69%

Effect of crude cottonseed oil containing gossypol on fertility of male and estrous cycle of femaleBandicota bengalensisGray and Hardwicke

Singla

Garg

2013

Journal of Applied Animal Research

View full text Add to dashboard Cite

Crude cottonseed oil (CCSO) containing 0.01% gossypol was evaluated in the present studies to record its effect on fertility of male and estrous cycle of female lesser bandicoot rat, Bandicota bengalensis Gray and Hardwicke. Laboratory feeding of bait (cracked wheat and powdered sugar in 98:2) containing 5 and 10% CCSO to female B. bengalensis for 13 days in no-choice feeding test, had no significant effect on the duration of the estrous cycle. However, laboratory feeding of bait containing 10% CCSO to male B. bengalensis for 15 and 30 days duration in a no-choice feeding test, significantly (P50.05) reduced sperm motility (%) and viability (%) in cauda epididymal fluid of treated rats compared to untreated ones. The weight of seminal vesicles of rats treated for 30 days was found to be significantly less (P 50.05) than that for rats treated for 15 days. No significant effect of treatment was observed on the breeding success of rats, diameter of seminiferous tubules, cell count and association of various germ cells in testis. Further studies may be conducted by increasing the duration of treatment or by using CCSO containing a higher concentration of gossypol.

show abstract

Section: Introductionmentioning

confidence: 69%

Effect of crude cottonseed oil containing gossypol on fertility of male and estrous cycle of femaleBandicota bengalensisGray and Hardwicke

Singla

Garg

2013

Journal of Applied Animal Research

View full text Add to dashboard Cite

show abstract

“…per day for Sprague-Dawley rats was identified (Heywood et al, 1986). In contrast, other authors found that 2.5 mg/kg per day of racemic gossypol was lethal to Wistar rats (Weinbauer et al, 1983). Daily subcutaneous injections of 1, 5, or 10 mg/kg b.w.…”

Section: Data From Experimental Animalsmentioning

confidence: 97%

Gossypol as undesirable substance in animal feed - Scientific Opinion of the Panel on Contaminants in the Food Chain

2009

EFSA Journal

View full text Add to dashboard Cite

“…However, the use of cottonseed as protein source is limited due to the presence of gossypol stored in pigment glands that is toxic to human beings and monogastric animals (Bell and Stipanovic. 1977;Sang et al 1980;Shandilya et al 1982;Weinbauer et al 1983;Heywood. 1988;Du et al 2004;Stipanovic et al 2006;Zhang et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning and characterization of an AP2/ERF protein gene in cotton (Gossypium hirsutumL.)

2023

Preprint

View full text Add to dashboard Cite

Upland cotton (Gossypium hirsutum L.) is one of the most economically important crops worldwide due to the significant source of natural fiber, feed, oil and biofuel products. Cottonseed can also serve as an excellent source of edible protein and oil. However,the presence of gossypol in pigment gland has limited it utilization. In the past few decades, some progress has been made in the understanding molecular mechanism of the formation of the pigment gland. However, little is known about the specific mechanism of pigment gland formation in cotton. In this study, the cDNA sequence of a ethylene transcription factor gene, designated GhERF105a, was cloned from upland cotton CCRI12. Sequence alignment revealed that GhERF105a gene contained a typical AP2/ERF domain of 61 amino acids, and belonged to the ERF subgroup of the ERF supfamily. It was highly expressed in the leaves and stems of glanded plants but had substantially lower expression of the glandless plants. GhERF105a, localized to the nucleus, could bind to GCC-box and DRE. Some development, phytohormone and stress related cis-elements were enriched in the promoters of GhERF105a/d. Split ubiquitin assays in yeast and BiFC experiments showed extensive interactions between GhERF105a and Gh_A07G1044. In addition, GhERF105a was highly similar with GhERF105d in the gene length, molecular weight, protein molecule, gene structure and expression pattern. The overall results suggested that GhERF105a might participate in the pigment gland formation and stree-response processes.

show abstract

Toxicity of Gossypol at Antifertility Dosages in Male Rats: Statistical Analysis of Lethal Rates and Body Weight Responses

Abstract: Daily administration of GAA was performed by oral intubation (1 d) under slight ether anesthesia.

Cited by 25 publications

References 14 publications

Effect of crude cottonseed oil containing gossypol on fertility of male and estrous cycle of femaleBandicota bengalensisGray and Hardwicke

Effect of crude cottonseed oil containing gossypol on fertility of male and estrous cycle of femaleBandicota bengalensisGray and Hardwicke

Gossypol as undesirable substance in animal feed - Scientific Opinion of the Panel on Contaminants in the Food Chain

Molecular cloning and characterization of an AP2/ERF protein gene in cotton (Gossypium hirsutumL.)

Contact Info

Product

Resources

About