Toxicity of glyphosate and aminomethylphosphonic acid (AMPA) to the early stages of development of Steindachneridion melanodermatum, an endangered endemic species of Southern Brazil

Barreto, Luiza Santos; Souza, Tugstênio Lima de; Morais, Tobias Pereira de; Ribeiro, Ciro Alberto de Oliveira

doi:10.1016/j.etap.2023.104234

Cited by 7 publications

(2 citation statements)

References 61 publications

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“…Among the degradation products of glyphosate, AMPA is the only persistent compound. From an analytical point of view, it is of primary importance to always monitor AMPA together with glyphosate since AMPA is the main metabolite of glyphosate [58,59]; from some research, it appears to have equal or greater toxicity compared to glyphosate itself [59,60]. The degradation of AMPA is generally slower than that of glyphosate, possibly because AMPA may adsorb onto soil particles more strongly than glyphosate and/or because it may be less likely to permeate the cell walls or membranes of soil microorganisms [55].…”

Section: Glyphosate Degradation Pathwaysmentioning

confidence: 99%

Chromatographic Methods for the Determination of Glyphosate in Cereals Together with a Discussion of Its Occurrence, Accumulation, Fate, Degradation, and Regulatory Status

Masci,

Caproni,

Nevigato

2024

MPs

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The European Union’s recent decision to renew the authorization for the use of glyphosate until 15 December 2033 has stimulated scientific discussion all around the world regarding its toxicity or otherwise for humans. Glyphosate is a chemical of which millions of tons have been used in the last 50 years worldwide to dry out weeds in cultivated fields and greenhouses and on roadsides. Concern has been raised in many areas about its possible presence in the food chain and its consequent adverse effects on health. Both aspects that argue in favor of toxicity and those that instead may indicate limited toxicity of glyphosate are discussed here. The widespread debate that has been generated requires further investigations and field measurements to understand glyphosate’s fate once dispersed in the environment and its concentration in the food chain. Hence, there is a need for validated analytical methods that are available to analysts in the field. In the present review, methods for the analytical determination of glyphosate and its main metabolite, AMPA, are discussed, with a specific focus on chromatographic techniques applied to cereal products. The experimental procedures are explained in detail, including the cleanup, derivatization, and instrumental conditions, to give the laboratories involved enough information to proceed with the implementation of this line of analysis. The prevalent chromatographic methods used are LC-MS/MS, GC-MS/SIM, and GC-MS/MS, but sufficient indications are also given to those laboratories that wish to use the better performing high-resolution MS or the simpler HPLC-FLD, HPLC-UV, GC-NPD, and GC-FPD techniques for screening purposes. The concentrations of glyphosate from the literature measured in wheat, corn, barley, rye, oats, soybean, and cereal-based foods are reported, together with its regulatory status in various parts of the world and its accumulation mechanism. As for its accumulation in cereals, the available data show that glyphosate tends to accumulate more in wholemeal flours than in refined ones, that its concentration in the product strictly depends on the treatment period (the closer it is to the time of harvesting, the higher the concentration), and that in cold climates, the herbicide tends to persist in the soil for a long time.

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Section: Glyphosate Degradation Pathwaysmentioning

confidence: 99%

Chromatographic Methods for the Determination of Glyphosate in Cereals Together with a Discussion of Its Occurrence, Accumulation, Fate, Degradation, and Regulatory Status

Masci,

Caproni,

Nevigato

2024

MPs

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“…In aquatic organisms, the effects of AMPA exposure are controversial, ranging from low toxicity to numerous adverse effects, including increased mortality, development delay, increased morphological abnormalities, genotoxicity, increased oxidative stress, cardiac defects, hepatic inflammatory response or changes in metabolic activity (Antunes et al, 2017; Barreto et al, 2023; Cheron et al, 2022; Cheron and Brischoux, 2023, 2020; Guilherme et al, 2014; Ivantsova et al, 2022; Levine et al, 2015; Martins-Gomes et al, 2022; Matozzo et al, 2018; Tartu et al, 2022; Zhang et al, 2021). However, despite the numerous adverse effects reported on non-target organisms, AMPA is not under particular scrutiny, and the underlying mechanisms involved in its ecotoxicity are poorly identified.…”

Section: Introductionmentioning

confidence: 99%

Maternal body condition affects the response of larval spined toads’ faecal microbiome to a widespread contaminant

Tartu,

Pollet,

Clavereau

et al. 2023

Preprint

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Glyphosate’s primary metabolite, aminomethylphosphonic acid (AMPA) is the most detected pollutant in surface waters. Recent studies have raised concerns regarding its toxicity, yet the involved underlying mechanisms remain poorly understood. A disruption of the gut microbiome, which plays a crucial role in host health, could be the mediator of most adverse effects. We investigated the impact of AMPA exposure on the gut microbiome of spined toad tadpoles (Bufo spinosus). We hypothesized that AMPA could alter the gut microbiota composition and that these effects could depend on the microbiota source. We exposed tadpoles to minute concentrations of AMPA and analyzed their faecal microbiota using 16S rRNA gene sequencing as a proxy of the gut microbiota. AMPA exposure decreased the gut bacterial biomass and affected bacterial community composition of tadpole’s faeces. Furthermore, we observed interactions between AMPA exposure and maternal body condition on the Bacteroidota and Actinobacteriota phyla abundances. This suggests a maternal effect on early-life microbial colonizers that could influence the response of the gut microbiome to AMPA. These findings highlight the importance of considering the gut microbiome when studying the effects of environmental contaminants. Further research is needed to elucidate the long-term implications of this microbiome alteration for amphibian health.

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Glyphosate and its formulated product Roundup Transorb R® affect locomotor activity and reproductive and developmental parameters in Jenynsia lineata fish: An intergenerational study

Moraes,

Ballesteros,

Hued

et al. 2024

Chemosphere

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Toxicity of glyphosate and aminomethylphosphonic acid (AMPA) to the early stages of development of Steindachneridion melanodermatum, an endangered endemic species of Southern Brazil

Cited by 7 publications

References 61 publications

Chromatographic Methods for the Determination of Glyphosate in Cereals Together with a Discussion of Its Occurrence, Accumulation, Fate, Degradation, and Regulatory Status

Chromatographic Methods for the Determination of Glyphosate in Cereals Together with a Discussion of Its Occurrence, Accumulation, Fate, Degradation, and Regulatory Status

Maternal body condition affects the response of larval spined toads’ faecal microbiome to a widespread contaminant

Glyphosate and its formulated product Roundup Transorb R® affect locomotor activity and reproductive and developmental parameters in Jenynsia lineata fish: An intergenerational study

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