Toxicity of DRC-1339 to Starlings

Decino, Thomas J.; Cunningham, Donald J.; Schafer, Edward W.

doi:10.2307/3797809

Cited by 57 publications

(40 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous research has hypothesized that the mode of action for CPTH toxicity involves damage to the kidneys (16), more specifically, damage to proximal tubular cells of the kidney (6,7,11). Additionally, observations of increased blood uric acid levels (7) have been made.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, observations of increased blood uric acid levels (7) have been made. The appearance of uric acid deposits in the abdominal cavities of exposed birds is also used as a method of determining exposure in certain cases (6,17,18). Renal damage of this type can be indicative of a highly reactive chemical that may be able to covalently bind to tissues.…”

Section: Resultsmentioning

confidence: 99%

“…The toxic effects of CPTH to birds have been known since the 1960s (4,5). Since that time, its continued use has sparked extensive research of this chemical (6)(7)(8)(9). A great deal is known about the acute toxicity of CPTH to various avian and mammalian species (10).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Absorption, Distribution, and Excretion of [¹⁴C]-3-Chloro-4-methylaniline Hydrochloride in Two Species of Birds Following a Single Oral Dose

Goldade

Tessari

Johnston

2004

J. Agric. Food Chem.

View full text Add to dashboard Cite

Ring-labeled [ 14 C]-3-chloro-4-methylaniline hydrochloride (250 µg per bird) was delivered to 21 redwinged blackbirds (Agelaius phoeniceus) and 21 dark-eyed juncos (Junco hyemalis) via oral gavage, and the distribution and excretion of radioactivity were determined at 15 and 30 min and 1, 4, 8, 12, and 24 h (n ) 3 per time point). Direct measurement of radioactivity as well as measurement following combustion was accomplished using a liquid scintillation counter. Elimination from most tissues followed a two-compartment model, with very rapid elimination occurring between time 0 and 4 h and a much slower elimination phase occurring after that. The average half-life of elimination for the initial phase in most tissues examined was 0.16 h for juncos and 0.62 h for blackbirds. The average for the slower second phase of elimination was 3.4 h for juncos and 5.4 h for blackbirds. The radioactivity in blackbird kidney tissues did not change significantly for the duration of the test, pointing toward the kidney as a possible site of action for this important agricultural chemical.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Absorption, Distribution, and Excretion of [¹⁴C]-3-Chloro-4-methylaniline Hydrochloride in Two Species of Birds Following a Single Oral Dose

Goldade

Tessari

Johnston

2004

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…The pesticide 3‐chloro‐ p ‐toluidine hydrochloride, (CPTH, 3‐chloro‐4‐methylaniline hydrochloride; DRC‐1339; Fig 1) was developed by the United States Fish and Wildlife Service for controlling European starlings ( Sturnus vulgaris L) in livestock feedlots 1. The United States Department of Agriculture/Animal and Plant Health Inspection Service/Wildlife Services (USDA/APHIS/WS) has used CPTH‐coated rice baits to reduce red‐winged blackbird ( Agelaius phoeniceus L) damage to rice in Louisiana and to sunflower in North and South Dakota 2, 3.…”

Section: Introductionmentioning

confidence: 99%

Probabilistic model for estimating field mortality of target and non‐target bird populations when simultaneously exposed to avicide bait

Johnston

Holmes²,

Hart³

et al. 2005

Pest Management Science

View full text Add to dashboard Cite

A probabilistic model was developed to estimate target and non-target avian mortality associated with the application of the avicide CPTH (3-chloro-p-toluidine hydrochloride) to minimize sprouting rice damage in the southern USA. CPTH exposures for individual birds were predicted by random sampling from species-specific non-parametric distributions of bait seed consumption and CPTH residues detected on individual bait seeds. Mortality was predicted from the species-specific exposure versus mortality relationship. Individual variations in this response were captured in the model by Monte Carlo sampling from species-specific distributions of slopes and median toxicity values (LD50) for each bird. The model was used to simultaneously predict mortality (percentage of exposed population and number of birds killed/weight of consumed bait) for a target (blackbird) and non-target (mourning dove) species feeding on bait sites for up to five consecutive days.

show abstract

“…In this category one chemical is of interest here: 3-chlorop-toluidine (3CPT). This compound is an effective agent agBinst starlings, crows and blackbirds (DeCino et al, 1966). According to Apostolou and Peoples (1971), 3CPT…”

Section: Avlcidesmentioning

confidence: 99%

Chemical-Induced ferrihemoglobin formation in birds

Blaauboer

Wit

1978

Vet Res Commun

View full text Add to dashboard Cite

show abstract

Toxicity of DRC-1339 to Starlings

Cited by 57 publications

References 1 publication

Absorption, Distribution, and Excretion of [¹⁴C]-3-Chloro-4-methylaniline Hydrochloride in Two Species of Birds Following a Single Oral Dose

Absorption, Distribution, and Excretion of [¹⁴C]-3-Chloro-4-methylaniline Hydrochloride in Two Species of Birds Following a Single Oral Dose

Probabilistic model for estimating field mortality of target and non‐target bird populations when simultaneously exposed to avicide bait

Chemical-Induced ferrihemoglobin formation in birds

Contact Info

Product

Resources

About

Toxicity of DRC-1339 to Starlings

Cited by 57 publications

References 1 publication

Absorption, Distribution, and Excretion of [14C]-3-Chloro-4-methylaniline Hydrochloride in Two Species of Birds Following a Single Oral Dose

Absorption, Distribution, and Excretion of [14C]-3-Chloro-4-methylaniline Hydrochloride in Two Species of Birds Following a Single Oral Dose

Probabilistic model for estimating field mortality of target and non‐target bird populations when simultaneously exposed to avicide bait

Chemical-Induced ferrihemoglobin formation in birds

Contact Info

Product

Resources

About

Absorption, Distribution, and Excretion of [¹⁴C]-3-Chloro-4-methylaniline Hydrochloride in Two Species of Birds Following a Single Oral Dose

Absorption, Distribution, and Excretion of [¹⁴C]-3-Chloro-4-methylaniline Hydrochloride in Two Species of Birds Following a Single Oral Dose