Toxicity of cypermethrin and deltamethrin insecticides on embryos and larvae of Physalaemus gracilis (Anura: Leptodactylidae)

Macagnan, Natani; Rutkoski, Camila Fátima; Kolcenti, Cassiane; Vanzetto, Guilherme Victor; Macagnan, Luan Paulo; Sturza, Paola F.; Hartmann, Paulo Afonso; Hartmann, Marília Teresinha

doi:10.1007/s11356-017-9727-5

Cited by 22 publications

(7 citation statements)

References 16 publications

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“…All insects including pollinators and other non target species are indiscriminately killed. Additionally, deltamethrin causes severe toxicity in aquatic ecosystems [45]. Despite this, pyrethroid insecticides remain the most efficacious vector control strategy for many hematophagous arthropod populations, although increasing reports of insecticide resistance compromise their efficacy [7,[46][47][48].…”

Section: Plos Biologymentioning

confidence: 99%

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

et al. 2021

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Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they negatively impact the environment and reduce populations of insect pollinator species. Here we present a promising, environment-friendly alternative to current insecticides that targets the insect tyrosine metabolism pathway. A bloodmeal contains high levels of tyrosine, which is toxic to haematophagous insects if it is not degraded and eliminated. RNA interference (RNAi) of either the first two enzymes in the tyrosine degradation pathway (tyrosine aminotransferase (TAT) and 4-hydroxyphenylpyruvate dioxygenase (HPPD)) was lethal to tsetse. Furthermore, nitisinone (NTBC), an FDA-approved tyrosine catabolism inhibitor, killed tsetse regardless if the drug was orally or topically applied. However, oral administration of NTBC to bumblebees did not affect their survival. Using a novel mathematical model, we show that NTBC could reduce the transmission of African trypanosomiasis in sub-Saharan Africa, thus accelerating current disease elimination programmes.

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Section: Plos Biologymentioning

confidence: 99%

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

et al. 2021

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“…Тести на ембріонах показали, що обидва піретроїдні пестициди викликали спазматичні скорочення, що свідчить про негативні неврологічні ефекти (Macagnan et al, 2017).…”

Section: смертність і виживання земноводнихunclassified

Biomarkers of the influence of pyrethroids and neonicotinoids on amphibian larvae

Gasso

Yermolenko

Bobyliov

et al. 2020

ean

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Currently, most amphibian populations in the world exist under the influence of numerous stress factors. Among them, the main factors that affect almost all terrestrial animals, namely, the fragmentation of habitats, environmental pollution and anthropic transformation of landscapes. Moreover, those factors are joined by negative causes that affect only amphibians – specific viral and fungal infections: ranaviruses (Ambystoma tigrinum virus (ATV), Bohle iridovirus (BIV), and frog virus 3) (also dangerous for some reptiles) and chytrid fungi (Batrachochytrium dendrobatidis and B. salamandrivorans). All these factors are one of the main reasons for the current global decline of amphibian populations in the world. In today's world, agricultural chemicals are one of the most important in terms of toxicity, environmental emissions and total area of impact. Among them, a significant proportion are formed by synthetic insecticides, which include pyrethroids and neonicotinoids. Pollution by these substances has a negative impact on amphibian populations, despite the relatively short period of their life in the environment. The vast majority of studies on the effects of pyrethroid and neonicotinoid insecticides were made in laboratory experiments with the larval stages of tailless amphibians. Tadpoles are easy to get in sufficient quantities and kept in the laboratory. Cypermethrin reduces the viability of tadpoles and causes precocious metamorphosis of survived larvae. However, in a combination with other pesticides, it delays metamorphosis. In addition, embryos were more resistant to pyrethroids than tadpoles. Pyrethroid pesticides cause spasms indicating adverse neurological effects. Formation of oral apparatus abnormalities in tadpoles, anisochromasia and increasing number of immature erythrocytes are also caused by pyrethroids. Neonicotinoids show similar effects. Under the action of imidacloprid the erythrocytes are also disturbed that is showed up in the DNA damage and micronuclei formation. Neurological disorders are manifested in the ability to perceive or respond to a predator, disorientation, erratic movement and loss of balance. Pyrethroids and neonicotinoids have been shown cause a variety of disorders: increase mortality and reduce survival of tadpoles; have a teratogenic effect and affect the metamorphosis and morphological parameters of amphibians; change many biochemical parameters that characterize the protein metabolism and oxidative stress; have genotoxic effects and affect the state of the nervous system and animal behaviour. Most of these parameters are proposed for use as biomarkers of pesticide intoxication.

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“…Among the organic chemicals, pyrethroids, that classified as highly effective and low-toxic biomimetic insecticides, are widely used to control pests in agriculture and residential areas. Deltamethrin (DM; C22H19Br2NO3) is one of the synthetic pesticides, which is widely utilized in agriculture, aquaculture, and animal rearing, because of its low toxicity and great effectiveness [6][7][8]. Consequently, it can enter different water sources like lakes and rivers, and therefore can be considered as one of the environmental threats to aquatic animals, including fish [9].…”

Section: Introductionmentioning

confidence: 99%

Deltamethrin and Retene Toxicity to Excitability of Ventricular Myocytes in Rainbow Trout (Oncorhynchus mykiss)

Badr

Vornanen

2023

Sohag Journal of Sciences

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Pyrethroids such as deltamethrin are widely used to control insect pests. Due to their selective toxicity to insects, they are considered harmless to birds and mammals. On the other hand, polycyclic aromatic hydrocarbons (PAHs) such as retene are widespread contaminants in aquatic ecosystems and more problematic to endothermic vertebrates. Both pyrethroids and PAHs might affect the developmental and functional processes in the cardiovascular system of fish. Therefore, deltamethrin and retene toxicity to the electrical excitability of ventricular myocytes were examined in the Oncorhynchus mykiss (rainbow trout) heart. Micromolar concentrations of deltamethrin and retene modified the action potential (AP) morphology in a time-dependent manner. After 5 min of application, both compounds strongly prolonged AP duration (APD) compared to control AP. However, deltamethrin prolonged APD by 42% and 25% more than retene at APD50 and APD90, respectively. In contrast, retene reduced APD10 and the AP depolarization rate (+dV dt -1 ) by 61% and 12% more than deltamethrin, respectively. Although deltamethrin and retene changed the ventricular AP shape in rainbow trout in the same way, their mechanism of action seems to be different. The findings revealed that deltamethrin mainly affects the outward potassium currents, while retene mainly affects the inward sodium and calcium currents. Further studies are needed to reveal the underlying ion currents/channels that might be involved in the AP attenuation of rainbow trout under the effect of deltamethrin and retene.

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Toxicity of cypermethrin and deltamethrin insecticides on embryos and larvae of Physalaemus gracilis (Anura: Leptodactylidae)

Cited by 22 publications

References 16 publications

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

Biomarkers of the influence of pyrethroids and neonicotinoids on amphibian larvae

Deltamethrin and Retene Toxicity to Excitability of Ventricular Myocytes in Rainbow Trout (Oncorhynchus mykiss)

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