Toxicity of certain Sudanese Plant Extracts to Cercariae and Miracidia of Schistosoma mansoni

El-Sheikh, S.; Bashir, A. K.; Suliman, Suad M.; Wassila, M

doi:10.3109/13880209009082825

Cited by 21 publications

(9 citation statements)

References 2 publications

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“…Compared to Phytolacca dodecandra, Tamarindus indica, Acacia nilotica, Hibiscus sabdariffa and Tacca leontapetaloides, the extract from Maesa lanceolata has a higher toxicity rate to the cercariae (El Sheik et al, 1990). The molluscicidal activity of apolar saponin fraction is the most toxic to biota than the polar one ( Table 3).…”

Section: Resultsmentioning

confidence: 98%

Environmental impact evaluation of the stem bark extract of Maesa lanceolata used in Democratic Republic of Congo

Bagalwa¹,

Chifundera

2007

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 98%

Environmental impact evaluation of the stem bark extract of Maesa lanceolata used in Democratic Republic of Congo

Bagalwa¹,

Chifundera

2007

Journal of Ethnopharmacology

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“…An aqueous extract of dried sepals of H. sabdariffa (100 ppm) was active against Schistosoma mansoni. However, an aqueous extract of dried seeds (10 000 ppm) was inactive against this trematode (Elsheikh et al, 1990).…”

Section: Antibacterial Antifungal and Antiparasitic Actionsmentioning

confidence: 99%

Phytochemical, pharmacological and toxicological aspects ofHibiscus sabdariffa L.: a review

Ali¹,

Al-Wabel²,

2005

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This article reviews the reported phytochemical, pharmacological and toxicological properties of Hibiscus sabdariffa L. (English: roselle, red sorrel; Arabic: karkade), the calyces of which are used in many parts of the world to make cold and hot drinks. Nutritionally, these contain ascorbic acid (vitamin C). In folk medicine, the calyx extracts are used for the treatment of several complaints, including high blood pressure, liver diseases and fever. The pharmacological actions of the calyx extracts include strong in vitro and in vivo antioxidant activity. In rats and rabbits, the extract showed antihypercholesterolaemic, antinociceptive and antipyretic, but not antiinflammatory activities. In rat and man a strong antihypertensive action has been demonstrated. The effects of the calyx extracts on smooth muscles in vitro are variable, but they mostly inhibit the tone of the isolated muscles. In healthy men, consumption of H. sabdariffa has resulted in significant decreases in the urinary concentrations of creatinine, uric acid, citrate, tartrate, calcium, sodium, potassium and phosphate, but not oxalate. Oil extracted from the plant's seeds has been shown to have an inhibitory effect on some bacteria and fungi in vitro. The plant extracts are characterized by a very low degree of toxicity. The LD50 of H. sabdariffa calyx extract in rats was found to be above 5000 mg/kg. A single report has suggested that excessive doses for relatively long periods could have a deleterious effect on the testes of rats. In view of its reported nutritional and pharmacological properties and relative safety, H. sabdariffa and compounds isolated from it (for example, anthocyanins and Hibiscus protocatechuic acid) could be a source of therapeutically useful products.

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“…In the case of the oils of Piper marginatum and Capsicum annuum, 90-96% of the cercariae of S. mansoni were killed within 15 min (Frischkorn et al 1978). Moreover, extracts from Phytolacca dodecandra, Tamarindus indica, Acacia nilotica, Hibiscus sabdariffa and Tacca leontopetaloides from Sudan were toxic to miracidia and cercariae at concentration from 50 to 100 mg/L (Elsheikh et al 1990).…”

Section: Toxicity To Schistosoma Mansoni Larvaementioning

confidence: 98%

Phytochemical analysis of Eucalyptus camaldulensis leaves extracts and testing its antimicrobial and schistosomicidal activities

et al. 2018

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Background: The emerging evolution of antibiotic and anthelmintic resistance and inefficiency of some synthetic drugs elicit the need to investigate new drug sources. In this context, Eucalyptus camaldulensis is an evergreen tree that has been widely used in traditional medicine for the treatment of various health disorders. Results: Organic solvent extracts from Eucalyptus camaldulensis leaves were assessed for their antimicrobial activity. Among these extracts, ethyl acetate (EtOAc) and water extracts showed the highest antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger. EtOAc extract was further subjected to vacuum liquid chromatography (VLC) technique for the isolation of its polyphenolic ingredients. VLC yielded 13 fractions (1-13) that were assayed for their antimicrobial activities. Six of these fractions, namely 4, 5, 6, 7, 8, and 9, showed antimicrobial activity against all the tested microbes except the fungus Aspergillus niger. Fractions 5 and 6 having considerably the highest antimicrobial activity with inhibition zones ranged from 5 to 14 mm. Moreover, fraction 5 was tested as a larvicidal agent against miracidia and cercariae of Schistosoma mansoni. At concentration of 200 mg/L, the mortality rates of miracidia and cercariae of Schistosoma mansoni were 30%, 20%, 50%, 40%, 80%, 20%, and 100%, 80% at 5, 10, 15, and 20 min, respectively. Chromatographic isolation of the EtOAc extract led to identification of six compounds: gallic acid (1), taxifolin (2), methyl gallate (3), quercetin (4), luteolin (5), and hesperidin (6). Conclusions: Ethyl acetate extract from Eucalyptus camaldulensis leaves showed a potent antimicrobial and antischistosomal activity. This activity may be attributed to the six phenolic compounds identified through structure elucidation. Thus, these compounds can be good candidates for treatment of microbes and for the control of schistosomiasis.

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Toxicity of certain Sudanese Plant Extracts to Cercariae and Miracidia of Schistosoma mansoni

Cited by 21 publications

References 2 publications

Environmental impact evaluation of the stem bark extract of Maesa lanceolata used in Democratic Republic of Congo

Environmental impact evaluation of the stem bark extract of Maesa lanceolata used in Democratic Republic of Congo

Phytochemical, pharmacological and toxicological aspects ofHibiscus sabdariffa L.: a review

Phytochemical analysis of Eucalyptus camaldulensis leaves extracts and testing its antimicrobial and schistosomicidal activities

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