Toxicity of Carbon Nanotubes: Molecular Mechanisms, Signaling Cascades, and Remedies in Biomedical Applications

Saleemi, Mansab Ali; Fouladi, Mohammad Hosseini; Yong, Phelim Voon Chen; Chinna, Karuthan; Palanisamy, Navindra Kumari; Wong, Eng Hwa

doi:10.1021/acs.chemrestox.0c00172

Cited by 69 publications

(49 citation statements)

References 188 publications

(409 reference statements)

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“…Carbon nanotubes (CNTs) were recently applied in PMMA, due to their strong antimicrobial effects and the mechanical properties enhancement [ 24 , 25 ]. However, the breakage of the material due to wear can release CNTs that are know to be toxic, as demonstrated in previously works [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 89%

Improvement of PMMA Dental Matrix Performance by Addition of Titanium Dioxide Nanoparticles and Clay Nanotubes

et al. 2021

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Over the last decades, several materials have been proposed for the fabrication of dental and mandibular prosthetic implants. Today, the poly(methyl-methacrylate) (PMMA) resin is the most spread material, due to its ease of processing, low cost, aesthetic properties, low weight, biocompatibility, and biostability in the oral cavity. However, the porous surface (which favors the adhesion of microorganisms) and the weak mechanical properties (which lead to wear or fracture) are the major concerns. The inclusion of engineered nanomaterials in the acrylic matrix could improve the performances of PMMA. In this study, we added two different kind of nanomaterials, namely titanium dioxide nanoparticles (TiO2NPs) and halloysite clay nanotubes (HNTs) at two concentrations (1% and 3% w/w) in PMMA. Then, we assessed the effect of nanomaterials inclusion by the evaluation of specific physical parameters: Young’s modulus, roughness, and wettability. In addition, we investigated the potential beneficial effects regarding the Candida albicans (C. albicans) colonization reduction, the most common yeast responsible of several infections in oral cavity. Our experimental results showed an improvement of PMMA performance, following the addition of TiO2NPs and HNTs, in a dose dependent manner. In particular, the presence of TiO2NPs in the methacrylate matrix induced a greater increase in PMMA stiffness respect to HNTs addition. On the other hand, HNTs reduced the rate of C. albicans colonization more significantly than TiO2NPs. The results obtained are of great interest for the improvement of PMMA physico-chemical properties, in view of its possible application in clinical dentistry.

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Section: Introductionmentioning

confidence: 89%

Improvement of PMMA Dental Matrix Performance by Addition of Titanium Dioxide Nanoparticles and Clay Nanotubes

et al. 2021

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“…An additional advantage of in vitro long-term exposure systems is that they permit the detection of different long-term effects, such as those related to the acquisition of a tumoral phenotype. Indeed, the cell-transformation ability of different NMs has already been reported using these experimental approaches, as demonstrated with cobalt nanoparticles [4], titanium dioxide nanoparticles [19], multiwalled carbon nanotubes [20], nickel oxide nanoparticles [26], and cerium oxide [15].…”

Section: Discussionmentioning

confidence: 88%

“…BEAS-2B cells were selected as the target since inhalation is the most likely route of unintentional human exposure to different NMs, including TiO 2 NP and MWCNT. Both NMs have been extensively used, and their environmental consequences and potential effects on humans have been recently reviewed [19,20].…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs as a Suitable Biomarker to Detect the Effects of Long-Term Exposures to Nanomaterials. Studies on TiO2NP and MWCNT

et al. 2021

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The presence of nanomaterials (NMs) in the environment may represent a serious risk to human health, especially in a scenario of chronic exposure. To evaluate the potential relationship between NM-induced epigenetic alterations and carcinogenesis, the present study analyzed a panel of 33 miRNAs related to the cell transformation process in BEAS-2B cells transformed by TiO2NP and long-term MWCNT exposure. Our battery revealed a large impact on miRNA expression profiling in cells exposed to both NMs. From this analysis, a small set of five miRNAs (miR-23a, miR-25, miR-96, miR-210, and miR-502) were identified as informative biomarkers of the transforming effects induced by NM exposures. The usefulness of this reduced miRNA battery was further validated in other previously generated transformed cell systems by long-term exposure to other NMs (CoNP, ZnONP, MSiNP, and CeO2NP). Interestingly, the five selected miRNAs were consistently overexpressed in all cell lines and NMs tested. These results confirm the suitability of the proposed set of mRNAs to identify the potential transforming ability of NMs. Particular attention should be paid to the epigenome and especially to miRNAs for hazard assessment of NMs, as wells as for the study of the underlying mechanisms of action.

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“…[65][66][67] Carbon nanotubes may cause adverse side effects at the state of agglomeration. [68,69] Therefore, these NIR dye/LnNP nanoprobes exhibit superior biocompatibility and have great potentials in the fields of bioscience and biomedicine.…”

Section: Biocompatibility Of Nanoprobesmentioning

confidence: 99%

Luminescent nano‐bioprobes based on NIR dye/lanthanide nanoparticle composites

et al. 2021

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Near-infrared (NIR) light, which has ignorable tissue scattering/absorption, minimal photodamage, and no autofluorescence interference, is highly favorable for bioapplications. NIR dye and lanthanide-doped nanoparticle (LnNP), as representative NIR-excited luminescence probes, have attracted increasing interest due to their unique optical property and low biological toxicity. Design of luminescence probes based on NIR dye/LnNP nanocomposites cannot only integrate the advantages but also achieve additional functions via regulating internal energy transfer pathways. In this review, we focus on the most recent advances in the development of NIR dye/LnNP nanocomposites as potential bioprobes, which cover from their fundamental photophysics to bioapplications, including energy transfer mechanisms, interface engineering (involving binding interaction, distance, and aggregation as key factors), and their applications for dye-sensitized upconversion/downshifting luminescent bioimaging, detection of biomolecules, and NIR-triggered diagnosis and therapy. Some future prospects and efforts toward this active research field are also envisioned. K E Y W O R D S dye sensitization, energy transfer, interface engineering, lanthanide-doped nanoparticle, nano-bioprobe, NIR dye This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Toxicity of Carbon Nanotubes: Molecular Mechanisms, Signaling Cascades, and Remedies in Biomedical Applications

Cited by 69 publications

References 188 publications

Improvement of PMMA Dental Matrix Performance by Addition of Titanium Dioxide Nanoparticles and Clay Nanotubes

Improvement of PMMA Dental Matrix Performance by Addition of Titanium Dioxide Nanoparticles and Clay Nanotubes

MicroRNAs as a Suitable Biomarker to Detect the Effects of Long-Term Exposures to Nanomaterials. Studies on TiO2NP and MWCNT

Luminescent nano‐bioprobes based on NIR dye/lanthanide nanoparticle composites

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