Toxicity of butyltin, phenyltin and inorganic tin compounds to sulfate-reducing bacteria isolated from anoxic marine sediments

Abstract

The toxicity of butyltin, phenyltin and inorganic tin compounds to three pure strains of sulfate‐reducing bacteria (SRB), isolated from a tributyltin (TBT)‐polluted sediment, was determined. The isolated strains were identified as belonging to the genus Desulfovibrio. A new toxicological index (GR25) was developed to assay the toxicity of organotin compounds. Deleterious effects on suspended anaerobic cell cultures were observed for concentrations ranging between 500 and 600 µM for tin tetrachloride, 55 and 260 µM for triorganotins, 30 and 90 µM for diorganotins, and 1 and 6 µM for mono‐organotins. Whereas the number of substituents influenced the toxicity of organotins, the type of substituent (butyl or phenyl) proved to have little or no impact. Trisubstituted compounds (tributyl‐ and triphenyl‐tin) were less toxic to these strains of SRB than the monosubstituted forms (monobutyl‐ and monophenyl‐tin). This is the opposite trend to that currently reported for aerobic organisms. Under the given anoxic conditions, the toxicity of organotin compounds obtained yielded a significant negative correlation with the total surface area (TSA) of the tested molecules. Comparison of the TBT toxicity data observed for different microbial groups suggests that the tolerance of bacteria to organotin compounds might be related to organotin–cell wall interactions as well as to aerobic or anaerobic metabolise pathways. Copyright © 2000 John Wiley & Sons, Ltd.

Review: Quantitative structure–activity/property relationships as related to organotin chemistry

“…The observed correlations differ from those reported earlier by Laughin et al and Eng et al In addition, the study indicated that the relationship observed with aerobic systems might not be valid for anaerobic systems. Boopathy and Daniels also observed a similar trend in their study involving methanogenic bacteria and a series of organotin sulfates and chlorides, agreeing with the findings of Belay et al Lascourrèges et al reported a similar observation in their study involving the toxicity of a series of organotins and three pure strains of sulfate‐reducing bacteria.…”

Toxicity of Lead in Aqueous Medium to Desulfovibrio Desulfuricans G20

“…Lag times were determined to be the last sampling time where cell protein concentrations were measured to be below the method detection limit (3 mg/L). The specific growth rate was estimated from the slope of the regression obtained by plotting total cell protein on a log scale versus time as described by Lascourreges et al [50]. In all cases, a least square line with r 2 Ͼ 0.91 was obtained.…”

Synthesis and characterization of di-phenyl-tinIV-salicyliden-ortho-aminophenols: Analysis of in vitro antitumor/antioxidant activities and molecular structures

“…One important finding for tin based drug design was that these chemicals were long ago known to localize in tumor tissue [6][7][8]. Since then, tin compounds were promising in the fight against cancer, leading to important advances to modulate toxicity [9], describe their interactions with model [10][11][12] and real cell membranes [13], the enhancement of solubility [14][15][16][17] and other pharmaceutical goals [18][19][20], such as their interaction towards cell machinery and specific parts of the cell [21][22][23][24][25]. The main variations led to the attachment of heteroelements and different C aliphatic or C aromatic substituents to tin center [26][27][28][29].…”