Toxicity of Bicyclic Phosphate GABA Antagonists to the Housefly, <i>Musca domestica</i> L.

1,4-Disubstituted 2,6,7-trioxabicyclo[2.2.2]octanes: a new class of insecticides

“…New types of insecticides are discovered by many approaches, one of which starts from known toxicants for other organisms and modifies their structure for potency on insects (Casida, 1976). Bicyclophosphorus esters such as i-Pr-C(CH20)3P=0 might be considered as candidate prototypes but they have little or no insecticidal activity (Casida et al, 1976;Milbrath et al, 1979) except to houseflies on injection (Ozoe et al, 1983) and they are highly toxic to mammals (Bellet and Casida, 1973;Casida et al, 1976;Milbrath et al, 1979). The related bicyclo-Pesticide Chemistry and Toxicology Laboratory, Department of Entomological Sciences, University of California, Berkeley, California 94720.…”

The Preparation of Reductively Dechlorinated Analogues of Endrin and Some Other Cyclodiene Insecticides

“…The chlorine atoms at C-1 and C-8 then correspond to additional a-substituents that can enhance the activity of f3-substituted y-butyrolactones and related structures. 20,21) The structure-activity relationships will be further discussed in a later publication.…”

Synthesis and structure-activity relationships of a series of insecticidal dioxatricyclododecenes acting as the noncompetitive antagonist of GABAA receptors

“…Other compounds included are as follows: 43, 5-phenyl-2,3:8,7-endo-4,6-dioxa-5-phosphabicyclo[7.2.1.0z'8]dodec-10-ene 5-oxide; 44, 5-(4-cyanophenyl)-2,3:8,7-endo-4,6-dioxatricyclo[7.2.1.02•8] dodecane; 45, picrotoxinin; 46, /3-endosulfan; 47, TBOB; 48, TBPS; 49, -BHC; 50, -BHC; 51, PS-4. Data on the insecticidal activity of 1,4, 30,32-44,46, and 47 were taken from Ozoe et al (1990), that (injection/+PB) of 45 from Ozoe et al (1983), that (injection) of 48 from Palmer and Casida (1985), and that of 51 from Ozoe et al (1992a).…”