Toxicity of amine-functionalized single-carbon nanotube (NH2 f-SWCNT) to Channel Catfish (Ietalurus Punetaus): Organ pathologies, oxidative stress, inflammation, and apoptosis

Gao, Xiaochan; Zheng, Xudong; Gao, Shiyang; Huang, Yong; Xiong, Jianli; Ren, Hongtao

doi:10.1016/j.chemosphere.2021.131133

Cited by 12 publications

(2 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carbon nanotube (CN) Multi-wall CN with a mixture of 5.6 wt% ferrocene in toluene Induces pro-inflammatory cytokines (Boyles et al, 2015) Single-wall CN with amine-functionalized group Induces TNFα and IL-1β (Gao et al, 2021a) Graphene oxide (GO) GO from Asbury Mills 3061 grade graphite GO with larger lateral size enhances the production of IL-6, TNFα and IL-1β (Ma et al, 2015) Vanillin-functionalized NP from a mixture of vanillin with GO Releases significantly higher level of IL1-β, TNF-α, GM-CSF, IL-6, IL-8 (Gurunathan et…”

Section: Type Of Nps Composition Of Np (−/+) Cargo Cytokine and Funct...mentioning

confidence: 99%

Nanoparticles and cytokine response

Nasrullah,

Meenakshi Sundaram,

Claerhout

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Synthetic nanoparticles (NPs) are non-viral equivalents of viral gene delivery systems that are actively explored to deliver a spectrum of nucleic acids for diverse range of therapies. The success of the nanoparticulate delivery systems, in the form of efficacy and safety, depends on various factors related to the physicochemical features of the NPs, as well as their ability to remain “stealth” in the host environment. The initial cytokine response upon exposure to nucleic acid bearing NPs is a critical component of the host response and, unless desired, should be minimized to prevent the unintended consequences of NP administration. In this review article, we will summarize the most recent literature on cytokine responses to nanoparticulate delivery systems and identify the main factors affecting this response. The NP features responsible for eliciting the cytokine response are articulated along with other factors related to the mode of therapeutic administration. For diseases arising from altered cytokine pathophysiology, attempts to silence the individual components of cytokine response are summarized in the context of different diseases, and the roles of NP features on this respect are presented. We finish with the authors’ perspective on the possibility of engineering NP systems with controlled cytokine responses. This review is intended to sensitize the reader with important issues related to cytokine elicitation of non-viral NPs and the means of controlling them to design improved interventions in the clinical setting.

show abstract

Section: Type Of Nps Composition Of Np (−/+) Cargo Cytokine and Funct...mentioning

confidence: 99%

Nanoparticles and cytokine response

Nasrullah,

Meenakshi Sundaram,

Claerhout

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…However, concerns have been raised about how safe this system is for fish. Gao et al [56] studied the toxicity effect of a single-walled carbon nanotube functionalised with amine (NH2 f -SWCNT) deposited in water and fish nutrient. After the test, changes in fish histology and the concentration-dependent oxidative stress were observed.…”

Section: Carbon-based Nanoparticlesmentioning

confidence: 99%

Toxicity and Cytotoxicity Effects of Selected Nanoparticles: A Review

Odaudu

Akinsiku

2022

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

The appreciable development in nanotechnology has drawn the attention of several researchers cutting across different fields. However, some nanoparticles have been identified to possess harmful effects on humans and the environment. Hence, putting these cause and effect patterns into context is highly required for future research and discussions about nanotechnology. This study reviewed existing literature on the toxicity and cytotoxicity effects of some nanoparticles to compare reaction patterns. Many kinds of research used different cell cultures, including cancer cell lines, human endothelial cells, hepatic cells, which were tested both in vitro and in vivo to check the mechanism of the possible toxicity effects. Adverse effects of nanoparticles identified involved damaged DNA leading to mutations and generation of reactive oxygen species (ROS). The prominent identified common toxicity responses in nanoparticle-cell interaction were lysosomes formation interference, necrosis and apoptosis, nanoparticles and protein interaction, and agglomerate formation in other body parts. Some reports showed that the causes of these responses might be due to the physicochemical properties of the interrogated particles, such as particle size, shape, surface functionalisation, surface charge. Furthermore, nanoparticles’ toxicity effects are both concentration-dependent and time-dependent, highly pronounced in chemical or physical-based synthetic routes. Cytotoxic effects of nanoparticles were mainly linked to their synthetic method, nature of the reducing agent, and culture media.

show abstract

Biocompatibility, Toxicity, and Immunological Effects of Functionalized Carbon Nanostructures

Akturk

2023

Handbook of Functionalized Carbon Nanostructures

View full text Add to dashboard Cite

Toxicity of amine-functionalized single-carbon nanotube (NH2 f-SWCNT) to Channel Catfish (Ietalurus Punetaus): Organ pathologies, oxidative stress, inflammation, and apoptosis

Cited by 12 publications

References 62 publications

Nanoparticles and cytokine response

Nanoparticles and cytokine response

Toxicity and Cytotoxicity Effects of Selected Nanoparticles: A Review

Biocompatibility, Toxicity, and Immunological Effects of Functionalized Carbon Nanostructures

Contact Info

Product

Resources

About