Toxicity of a molluscicide candidate PPU07 against Oncomelania hupensis (Gredler, 1881) and local fish in field evaluation

Chen, Zhuo; Wang, Weisi; Yao, Junmin; Li, Shi-Zhu; Zhang, Xia; He-Hua, Hu; Liu, Xiong; Luo, Binrong; Liu, Yuhua; Xu, Huiyong; Duan, Liping

doi:10.1016/j.chemosphere.2019.01.102

Cited by 12 publications

(16 citation statements)

References 24 publications

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“…Furthermore, compound 21 (named PPU07) was made into the form of 25% PPU07 sulfate WP. The field molluscicidal activity and toxicity of 25% PPU07 sulfate WP were investigated against O. hupensis and local fish (Chen et al 2019 ). In the spraying experiments, the mortality of snails was up to 95% at the concentration of 2.0 g/m 2 .…”

Section: Development Of Chemical Molluscicidesmentioning

confidence: 99%

“…Recently, some achievements on the discovery of novel chemical and natural molluscicides have been accomplished to control snails (Chen et al 2019 ; de Paula-Andrade et al 2019 ). For the development of new molluscicides, exploration of the mechanism is important for the enhancement of molluscicidal activity and the reduction in non-target toxicity (Huang 2019a , b ).…”

Section: Mechanism Researchmentioning

confidence: 99%

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Molluscicides against the snail-intermediate host of Schistosoma: a review

et al. 2021

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Schistosomiasis, a neglected tropical disease (NTD), is one of the most prevalent parasitoses in the World. Certain freshwater snail species are the intermediate host in the life cycle of schistosome species. Controlling snails employing molluscicides is an effective, quick, and convenient intervention strategy to prevent the spread of Schistosoma species in endemic regions. Advances have been made in developing both synthetic molluscicides and molluscicides derived from plants. However, at present, the development of molluscicides is not adapted to the actual demand for snails and schistosoma controlling. We undertake a systematic review of exploitation and application of synthetic molluscicides and molluscicides derived from plants to combat intermediate host snails. The detailed molluscicidal activity, structure–activity relationship, structural feature, and possible mechanism of some molluscicides are also highlighted, which may afford an important reference for the design of new, more effective molluscicides with low environmental impact and realize the aim of controlling schistosome at transmission stages. Supplementary Information The online version contains supplementary material available at 10.1007/s00436-021-07288-4.

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Section: Development Of Chemical Molluscicidesmentioning

confidence: 99%

Section: Mechanism Researchmentioning

confidence: 99%

Molluscicides against the snail-intermediate host of Schistosoma: a review

et al. 2021

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“…25 Relatively weaker potency was observed in O. hupensis, probably due to its amphibious habitat and thicker shell. 26 We also found that the susceptibility of P. canaliculata to PBQ was dependent on the developmental stage. A substantially lower LC 50 was recorded for juveniles, indicating their higher susceptibility to PBQ.…”

Section: Discussionmentioning

confidence: 57%

“…25 PBQ exhibited strong molluscicidal potency against B. straminea 25 and O. hupensis. 26 In addition, PBQ has low toxicity to local fishes, 25,26 suggesting its relative safety to nontarget organisms. The aim of this work was to expand our knowledge of the molluscicidal spectrum of PBQ to P. canaliculata.…”

Section: Introductionmentioning

confidence: 99%

Control of the Invasive Agricultural Pest Pomacea canaliculata with a Novel Molluscicide: Efficacy and Safety to Nontarget Species

Wang

Huang

Liu

et al. 2022

J. Agric. Food Chem.

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The golden apple snail Pomacea canaliculata is an invasive pest that causes extensive damage to agricultural production. P. canaliculata is also an intermediate host of Angiostrongylus cantonensis, which causes human eosinophilic meningitis. In this study, the molluscicidal activity and safety profile of a novel molluscicide PBQ [1-(4-chlorophenyl)-3-(pyridin-3-yl)urea] were evaluated. PBQ exhibited strong molluscicidal potency against adult and juvenile snails (LC 50 values of 0.39 and 0.07 mg/L, respectively). In field trials, PBQ killed 99.42% of the snails at 0.25 g a.i./m 2 . An acute toxicity test in rats demonstrated that PBQ is a generally nonhazardous chemical. PBQ is also generally safe for nontarget organisms including Brachydanio rerio, Daphnia magna, and Apis mellifera L. Transcriptomics analysis revealed that PBQ had a significant impact on the carbohydrate and lipid metabolism pathways, which provided insights into its molluscicidal mechanism. These results suggest that PBQ could be developed as an effective and safe molluscicide for P. canaliculata control.

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“…ere is a growing interest in phytochemicals with potent molluscicidal activity a er the successful use of Phytolacca dodecandra in the snail population control of schistosome vectors in Egypt [7,8,11]. Synthesis of new compounds and structure-activity relationship with known molluscicides are also gaining popularity [9,10,12,13]. Both research strategies will require an assay which uses a small amount of test substance while maintaining accuracy and reproducibility.…”

Section: Introductionmentioning

confidence: 99%

A New Method to Test Molluscicides against the Philippine Schistosomiasis Snail Vectors

Gomez

Anacta

2020

Journal of Parasitology Research

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To expedite the discovery of novel molluscicides in the laboratory, this study aimed to evaluate the performance of a new molluscicidal assay. This assay is based on Oncomelania hupensis quadrasi snails and is called miniaturized plate test or mpt. To perform this assay, a 12-well plate, 3 snails per well, and 24-h exposure period were used. The performance of mpt was evaluated using niclosamide and Ardisia plant extract (tagpo extract) as test substances while WHO’s guidelines for a conventional plate test (cpt) served as standard. One cpt and four mpt independent trials were performed for niclosamide and tagpo extract. Probit analysis of dose–response data was run in R to generate lethal concentrations (LC50 and LC90), while lethal ratio test was performed to detect significant difference between paired LC50s (or LC90s). Using niclosamide, the calculated LC50 values were 0.104, 0.127, 0.136, 0.139, and 0.140 g/m2 for cpt, mpt 1, mpt 2, mpt 3, and mpt 4, respectively, while the LC90 values were 0.266, 0.268, 0.244, 0.251, and 0.261 g/m2, using the same sequence, respectively. For tagpo extract, the LC50 values were 1.467, 1.547, 1.659, 1.797, and 1.659 g/m2, for cpt, mpt 1, mpt 2, mpt 3, and mpt 4, respectively, and the LC90s were 2.188, 2.195, 2.501, 2.358, and 2.501 g/m2, respectively. The lethal ratio test revealed that a significant difference exists between the LC50s of cpt and mpt 1 when using niclosamide with a lethal ratio and confidence limits of 0.820 (0.663, 0.977, p<0.05) and another significant difference between LC50s of mpt 1 and mpt 3 using tagpo extract with computed lethal ratio and confidence limits of 0.861 (0.782, 0.939, p<0.05). Taken together, the results point out that mpt generates accurate and reproducible lethal concentration values. Hence, mpt may be used as an alternative method to screen molluscicides that are active against schistosome snail vectors.

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Toxicity of a molluscicide candidate PPU07 against Oncomelania hupensis (Gredler, 1881) and local fish in field evaluation

Cited by 12 publications

References 24 publications

Molluscicides against the snail-intermediate host of Schistosoma: a review

Molluscicides against the snail-intermediate host of Schistosoma: a review

Control of the Invasive Agricultural Pest Pomacea canaliculata with a Novel Molluscicide: Efficacy and Safety to Nontarget Species

A New Method to Test Molluscicides against the Philippine Schistosomiasis Snail Vectors

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