Toxicity in Uremia 2. Correlation between PTH Levels and Impaired Aspecific Immunity

Esposito, Roberta; Romano-Carratelli, Caterina; Lanzetti, N; Hohenegger, M; Pluvio, M; Capodicasa, G; Nuzzo, I.; Giordano, C

doi:10.1177/039139888801100306

Cited by 5 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reduc Esposito et al [40] reported that dialysis patients fall into two groups with regard to their phagocytosis. The first had high blood levels of PTH and impaired phago cytosis while in the second group the PTH levels were modestly elevated and phagocytosis was normal.…”

Section: Discussionmentioning

confidence: 99%

Impaired Phagocytosis in Dialysis Patients: Studies on Mechanisms

et al. 1991

View full text Add to dashboard Cite

Dialysis patients have increased susceptibility to infection and this is, in part, due to impaired phagocytic and bactericidal activities of polymorphonuclear leukocytes (PMNL). The mechanisms responsible for the reduced phagocytosis are not known. Dialysis patients have elevated blood levels of parathyroid hormone (PTH), and available data indicate that PMNL is a target cell for PTH. Chronic exposure to excess PTH may cause accumulation of calcium in PMNL which in turn could adversely affect cellular events leading to their dysfunction. We studied phagocytosis, resting levels of cytosolic calcium ([Ca²⁺]_i), ATP content and the rise in [Ca²⁺]_i in response to ligation of Fcγ RIII receptors with 3G8 monoclonal antibody in PMNL from 37 dialysis patients and 48 normal subjects. The PMNL from the dialysis patients displayed impaired phagocytosis, elevated resting levels of [Ca²⁺]_i, decreased ATP content and a smaller rise in [Ca²⁺]_i in response to various doses of 3G8 monoclonal antibody as compared to values obtained in PMNL of normal subjects. Our results suggest that derangements in cellular metabolism and possibly an abnormality in Fcγ RIII interaction with antibody and/or the consequences of such interaction are responsible, at least in part, for the impaired phagocytosis of PMNL of dialysis patients. Our data are consistent with the notion that excess PTH may play an important role in the processes leading to impaired phagocytosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Impaired Phagocytosis in Dialysis Patients: Studies on Mechanisms

et al. 1991

View full text Add to dashboard Cite

show abstract

“…In addition, Doherty et al [61] demonstrated that migration of PMNL from patients with advanced renal failure was reduced and that there is an inverse relationship between random migration of PMNLs and serum levels of PTH. Esposito et al [67] studied the role of PTH in depressing PMNLs phagocytic function in uremia. The data produced shows that phagocytosis is lowered in uremic patients with both low and high plasma PTH but more noticeably in the group with high plasma PTH.…”

Section: Pth and Polymorphonuclear Leukocytesmentioning

confidence: 99%

Effects of Parathyroid Hormone on Immune Function

Geara

Castellanos

Bassil

et al. 2010

Journal of Immunology Research

View full text Add to dashboard Cite

Parathyroid hormone (PTH) function as immunologic mediator has become interesting with the recent usage of PTH analogue (teriparatide) in the management of osteoporosis. Since the early 1980s, PTH receptors were found on most immunologic cells (neutrophils, B and T cells). The in vitro evaluations for a possible role of PTH as immunomodulator have shown inconsistent results mainly due to methodological heterogeneity of these studies: it used different PTH formulations (rat, bovine, and human), at different dosages and different incubating periods. In some of these studies, the lymphocytes were collected from uremic patients or animals, which renders the interpretation of the results problematic due to the effect of uremic toxins. Parathyroidectomy has been found to reverse the immunologic defect in patients with high PTH levels. Nonetheless, the clinical significance of these findings is unclear. Further studies are needed to define if PTH does have immunomodulatory effects.

show abstract