2023
DOI: 10.1002/jbm.b.35241
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Toxicity evaluation of choline ionic liquid‐based nanocarriers of pharmaceutical agents for lung treatment

Abstract: In vitro cytotoxicity evaluation of linear copolymer (LC) containing choline ionic liquid units and its conjugates with an antibacterial drug in anionic form, that is, p‐aminosalicylate (LC_PAS), clavulanate (LC_CLV), or piperacillin (LC_PIP) was carried out. These systems were tested against normal: human bronchial epithelial cells (BEAS‐2B), and cancers: adenocarcinoma human alveolar basal epithelial cells (A549), and human non‐small cell lung carcinoma cell line (H1299). Cells viability, after linear copoly… Show more

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Cited by 4 publications
(2 citation statements)
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“…Previous reports on the cytotoxic evaluation of linear and graft copolymers based on TMAMA as matrices for drug delivery systems indicated non-cytotoxic effects towards normal human bronchial epithelial cells (BEAS-2B) and cytotoxic effects on adenocarcinomic human alveolar basal epithelial cells (A549) [72,73]. Basic cytotoxicity studies were conducted using the colorimetric MTT assay at various concentrations of polymer systems (3-100 µg/mL) on BEAS-2B cell lines to assess their impact on cell viability.…”
Section: In Vitro Cytotoxicity Assaymentioning
confidence: 99%
“…Previous reports on the cytotoxic evaluation of linear and graft copolymers based on TMAMA as matrices for drug delivery systems indicated non-cytotoxic effects towards normal human bronchial epithelial cells (BEAS-2B) and cytotoxic effects on adenocarcinomic human alveolar basal epithelial cells (A549) [72,73]. Basic cytotoxicity studies were conducted using the colorimetric MTT assay at various concentrations of polymer systems (3-100 µg/mL) on BEAS-2B cell lines to assess their impact on cell viability.…”
Section: In Vitro Cytotoxicity Assaymentioning
confidence: 99%
“…The polymerization of choline MILs modified with pharmaceutical anions, such as salicylate [31,36,37], fusidate [38], cloxacillin [38], and PAS [39], have been reported. Cytotoxicity tests on the choline-based copolymers have demonstrated their non-toxic effects on normal BEAS-2B and cytotoxic activity against lung cancer cell lines [40,41].…”
Section: Introductionmentioning
confidence: 99%