Toxicity evaluation and initial characterization of the venom of a Colombian Latrodectus sp.

Rueda, Alexandra; Realpe, Emilio; Uribe, Alfredo

doi:10.1016/j.toxicon.2016.11.255

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…Finally, other important f indings from Colombian toxinologists have been obtained at Universidad de Los Andes, where venom from Colombian Latrodectus sp was characterized for the first time (118). That study demonstrated that the venom of Colombian Latrodectus sp induced effects that were similar to those of other venoms from this genus and contained proteins of different molecular masses.…”

Section: Other Researchesmentioning

confidence: 86%

Toxinology in Colombia: Contributions of Programa De Ofidismo/Escorpionismo and Other Research Groups

Pereañez

Preciado

Romero

2020

Vitae

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Background: Toxinology is a field of toxicology involved in studying toxins from animals, plants and microorganisms. In Colombia, in last thirty years, this area has been mainly studied by Programa de Ofidismo/Escorpionismo of the Universidad de Antioquia, however, some other research groups have been also contributed in our knowledge of venoms, toxin, effects and treatments. Objective: highlights the most important findings in toxinology made by Programa de Ofidismo/Escorpionismo and other research groups in Colombia. Methods: we collected and analyze119 manuscripts dealing with the history of ophidiology and toxinology in Colombia. Results: we describe some useful terms to understand the toxinology and their scopes. In addition, we build a brief history of ophidiology beginning with the period corresponding to the discovery of America, and ending with recent findings. Finally, we perform a great description of several results related to toxin isolation, characterization, antivenoms, clinical trials, new species descriptions, pretoemic and transcriptomic, among other. The nineteens was characterized by the study of snakebites, their clinic manifestations and the use of antivenoms. In addition, the ethnopharmacological studies of medicinal plants used in snakebite treatments began to be explored. The 2000s included the newly ethnopharmacology, toxin isolation, clinical trials, inhibitor studies, scorpion venom characterization and scorpion stings features. Finally, from 2010 until today, proteomic and transcriptomic gave the most important findings. Conclusions: Toxinology works in Colombia have contributed in our knowledge about endemic species, clinical manifestations of snakebites and scorpion stings, however, we invite to Colciencias and other funding agencies to have more resources in order to support more researchers in this field, since, snakebite is a public neglected disease and need more attention from governments and academic people. Finally, we still have ignorance about the venoms of some species and their possible mode of action. In addition, given the complexity of venoms, we ignore the potential use of toxins in current biomedicine. Thus, we must continue performing studies in toxinology.

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Section: Other Researchesmentioning

confidence: 86%

Toxinology in Colombia: Contributions of Programa De Ofidismo/Escorpionismo and Other Research Groups

Pereañez

Preciado

Romero

2020

Vitae

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“…venoms have been isolated or biochemically tested for their activity. In addition to latrotoxins and latrodectins, previous studies reported the presence of a variety of molecules, such as protease inhibitors and different types of enzymes (proteases and hyaluronidase) [187], and other components as part of the venom such as adenosine, guanosine, inosine, and serotonin [113,147,187], shown in Table 2.…”

Section: Venom Componentsmentioning

confidence: 99%

Widow spiders in the New World: a review on Latrodectus Walckenaer, 1805 (Theridiidae) and latrodectism in the Americas

Caruso

Lauria

Souza

et al. 2021

J. Venom. Anim. Toxins incl. Trop. Dis

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Humankind has always been fascinated by venomous animals, as their toxic substances have transformed them into symbols of power and mystery. Over the centuries, researchers have been trying to understand animal venoms, unveiling intricate mixtures of molecules and their biological effects. Among venomous animals, Latrodectus Walckenaer, 1805 (widow spiders) have become feared in many cultures worldwide due to their extremely neurotoxic venom. The Latrodectus genus encompasses 32 species broadly spread around the globe, 14 of which occur in the Americas. Despite the high number of species found in the New World, the knowledge on these spiders is still scarce. This review covers the general knowledge on Latrodectus spp. from the Americas. We address widow spiders' taxonomy; geographical distribution and epidemiology; symptoms and treatments of envenomation (latrodectism); venom collection, experimental studies, proteome and transcriptome; and biotechnological studies on these Latrodectus spp. Moreover, we discuss the main challenges and limitations faced by researchers when trying to comprehend this neglected group of medically important spiders. We expect this review to help overcome the lack of information regarding widow spiders in the New World.

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Toxicity evaluation and initial characterization of the venom of a Colombian Latrodectus sp.

Cited by 2 publications

References 34 publications

Toxinology in Colombia: Contributions of Programa De Ofidismo/Escorpionismo and Other Research Groups

Toxinology in Colombia: Contributions of Programa De Ofidismo/Escorpionismo and Other Research Groups

Widow spiders in the New World: a review on Latrodectus Walckenaer, 1805 (Theridiidae) and latrodectism in the Americas

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