2022
DOI: 10.1016/j.jinorgbio.2022.111720
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Toxicity assessments and transcriptional effects of monofunctionalized Pt(II) complex under dark and light irradiation condition in Caenorhabditis elegans

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Cited by 2 publications
(5 citation statements)
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“…From a comparison between the values obtained for dCBP and its parent Pyrim , it appears that the presence of the appended BODIPY does not play a significant role at this stage and the more sterically hindered structure of the binuclear Pt complex, regardless the presence of the BODIPY moiety, penalizes the second guanine attack. According to the enhanced experimentally observed loss of DNA helical structure for dCBP , , it can be inferred from such results that, in analogy to phenanthriplatin, , the first attack to a guanine base causes an initial DNA double helix distortion. Such a distortion could lead to a rearrangement of the real DNA flexible structure more favorable to the second guanine attack and, therefore, to cross-linking.…”
Section: Resultsmentioning
confidence: 98%
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“…From a comparison between the values obtained for dCBP and its parent Pyrim , it appears that the presence of the appended BODIPY does not play a significant role at this stage and the more sterically hindered structure of the binuclear Pt complex, regardless the presence of the BODIPY moiety, penalizes the second guanine attack. According to the enhanced experimentally observed loss of DNA helical structure for dCBP , , it can be inferred from such results that, in analogy to phenanthriplatin, , the first attack to a guanine base causes an initial DNA double helix distortion. Such a distortion could lead to a rearrangement of the real DNA flexible structure more favorable to the second guanine attack and, therefore, to cross-linking.…”
Section: Resultsmentioning
confidence: 98%
“…Unlike cisplatin, nonetheless, only a single bond can be formed with DNA, as in such drugs only one labile ligand is bound to the metal center, and due to additional interactions and steric hindrance, cellular repair ability via transcription is reduced and apoptosis is induced with a different mechanism. , Aiming at enhancing the efficacy of monofunctional anticancer agents, dual-action complexes have been designed by appending a suitable photosensitizer (PS) to the ligand bound to platinum­(II). Two-component systems of this kind have recently received increasing attention due to the possibility to combine the DNA cross-linking ability of the complex bearing a labile anionic ligand, generally a chloride, with the photodynamic therapy (PDT) effect of a PS. PDT is an alternative treatment for the control of malignant diseases based on the uptake of a photosensitizing molecule which, upon being excited by light of proper wavelength, reacts with oxygen and generates oxidant species in target tissues, leading to cell death. , The PS, in the photodynamic process, is promoted from its ground singlet state to an excited one. The excitation is followed by an intersystem crossing (ISC) transition to a lower triplet state, being a usually forbidden nonradiative process that can take place if the relativistic spin–orbit coupling (SOC) between the two states is large enough and the involved states are close in energy to permit the process to be efficient.…”
Section: Introductionmentioning
confidence: 99%
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“…7 When the photosensitizer is activated by light, it transfers energy to molecular oxygen, generating reactive oxygen species that can damage cellular components and induce cell death. 8 The use of Pt( ii ) complexes as photosensitizers in PDT is an active area of research, as they offer several advantages over traditional photosensitizers, including higher stability and greater water solubility.…”
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confidence: 99%