Toxicity assessment of watermelon seed supplemented diet in rats

Oyenihi, Omolola R.; Afolabi, Blessing A.; Oyenihi, Ayodeji B.; Ojo, Gideon B

doi:10.1080/01480545.2021.1894699

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…Furthermore, compared with control, there were no significant differences in all animals' functions and plasma levels of alkaline phosphatase, cholesterol, triglycerides, and alanine aminotransferase. Nevertheless, compared with control, there was a considerable (p<0.05) rise in plasma creatinine and urea levels in the test animals [71].…”

Section: Toxicological Studiesmentioning

confidence: 73%

Untitled

2022

J. Med. Chem. Sci.

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Citrullus lanatus is a fruit that is eaten and carries many by-products like rind and seeds that are abandoned and fed to animals. Numerous studies have demonstrated the bio-medical properties of Citrullus lanatus by-products, making it a superior choice of natural source for medicinal products. Citrullus lanatus by-products' medical properties are due to their pharmacological significance, related to the availability of essential phytochemicals such as saponin, alkaloids, fatty acids, phenolic, citrulline, lycopene, coumarin, minerals, and other natural products. Gastrointestinal ulceration, diabetes, hypertension, cardiovascular disorders, and many kinds of malignancies have been treated with these by-products extract. The following review aimed to provide a thorough summary of the advantages of Citrullus lanatus byproducts in the management of different ailments.

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Section: Toxicological Studiesmentioning

confidence: 73%

Untitled

2022

J. Med. Chem. Sci.

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“…Studies have indicated that many herbs used in traditional medicine may produce adverse effects. Data from Oyenihi et al (2022) revealed that consumption of watermelon seed may lead to tissue-related toxicity specifically in the testes. This finding raises a safety concern for humans, especially chronic consumers.…”

Section: Safetymentioning

confidence: 99%

“…This finding raises a safety concern for humans, especially chronic consumers. The consumption of these seeds at high doses could be detrimental to male reproductive function as evidenced by a significant decrease in sperm morphology in rats ( Oyenihi et al , 2022 ). Additional dose-related studies and an extended experimental period are required to identify the safe dosing range for watermelon seed to maximize its potential health benefits.…”

Section: Introductionmentioning

confidence: 99%

Impact of Watermelon (Citrallus lanatus) on Male Fertility

Rotimi¹,

Asaleye²

2022

JBRA

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Plants have been used in various regions of the world to treat various medical conditions including male infertility. The review aims to evaluate the pharmacological effects of watermelon consumption in improving male fertility and sexual function. Watermelon is a popular fruit consumed around the world for its diverse nutritional and healthpromoting qualities. This study showed the mechanism via which watermelon enhances male fertility as it was reported for improving semen quality, reversing erectile dysfunction, enhancing testicular redox status, as well as improving gonadotropin secretion. These activities have been linked to their constituents as it contains vitamins and phytochemicals such as phenols and certain flavonoids that contribute to their antioxidant properties. Watermelon has also been noted to possess antimicrobial, antihelminthic, antioxidant, antidiabetic, anti-inflammatory, and antihypertensive properties that may contribute to its therapeutic use.

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