Toxicity assessment of sodium fluoride in Drosophila melanogaster after chronic sub-lethal exposure

Dutta, Moumita; Rajak, Prem; Khatun, Salma; Roy, Sumedha

doi:10.1016/j.chemosphere.2016.09.112

Cited by 58 publications

(23 citation statements)

References 46 publications

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“…Our data agree with the report of Dutta et al. 33 in which AChE activity was inhibited in the larva of flies exposed to NaF. This effect would have caused accumulation of acetylcholine which may lead to overstimulation of the acetylcholine receptors.…”

Section: Discussionsupporting

confidence: 93%

Protective role of resveratrol, a natural polyphenol, in sodium fluoride-induced toxicity inDrosophila melanogaster

Abolaji

Ajala

Adigun

et al. 2019

Exp Biol Med (Maywood)

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Sodium fluoride (NaF) is used in water fluoridation and dental products such as mouth rinses and toothpastes. Resveratrol is a natural polyphenol with antioxidant and anti-inflammatory properties. The present study was carried out to evaluate the toxicity of NaF and the protective role of resveratrol in Drosophila melanogaster. For longevity assay, Harwich strain of D. melanogaster was treated with NaF (0, 10, 30, 50, 70 and 90 mg/kg diet) throughout the lifespan and daily mortality recorded. Then, flies were again treated with similar doses of NaF for seven days to evaluate survival rate and oxidative stress markers. Thereafter, 60 mg resveratrol/kg diet was selected to determine its ameliorative role in NaF (70 mg/kg)-induced toxicity in flies: Group A (control), Group B (60 mg resveratrol/kg diet), Group C (70 mg NaF/kg diet), and Group D (resveratrol, 60 mg/kg diet) + NaF, 70 mg/kg diet). Thereafter, Glutathione-S-transferase (GST), catalase and acetylcholinesterase (AchE) activities, as well as total thiol (T-SH), nitrites/nitrates and hydrogen peroxide (H2O2) levels were determined. The results showed that resveratrol prevented NaF-induced elevation of H2O2 and nitrites/nitrates levels, as well as catalase activity. In addition, resveratrol restored NaF-induced inhibition of GST and AChE activities and depletion of T-SH content ( P < 0.05). Conclusively, resveratrol offered protective benefit against NaF-mediated toxicity in flies due to its antioxidant and anti-inflammatory properties. Impact statement D. melanogaster was used to understand the impact of NaF on lifespan and emergence rate as well as the rescue role of resveratrol. These parameters are difficult to carry out in previously used models such as rodents. This further enforces in part, the suitability of D. melanogaster in studying NaF-induced toxicity and the therapeutic effects of drugs. Additionally, we found that resveratrol rescued D. melanogaster from oxidative stress-induced by sodium fluoride (NaF) administration. This study is of public health significance as it indicated that the consumption of fruits rich in resveratrol such as grapes may offer protective role against inadvertent exposure to NaF and related chemicals.

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Section: Discussionsupporting

confidence: 93%

Protective role of resveratrol, a natural polyphenol, in sodium fluoride-induced toxicity inDrosophila melanogaster

Abolaji

Ajala

Adigun

et al. 2019

Exp Biol Med (Maywood)

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“…[ 15 ] The potential toxicity of HF would relatively reduce the enzyme activity or cause a significant damage to the normal cells in vivo, which dramatically hinders the further exploration of Nb 2 CT x in biomedical applications. [ 16 ] iv) In view of the flexible terminations of HF‐etched Nb 2 CT x , it is easy to be oxidized under ambient environment or during the oxygen evolution reaction (OER) process, [ 17 ] severely affecting the instability and effectiveness of Nb 2 CT x in biosensing process. Recently, Yang et al.…”

Section: Figurementioning

confidence: 99%

“…Although HF or in situ HF etching method is extensively used for MXenes production, the synthesis process requires relatively long etching time and extra protective procedures. In addition to the fluorine residues on the surface after synthesis, HF‐etched Nb 2 CT x is also prone to be oxidized under ambient environment or during the OER process, [ 16 ] significantly affecting the instability and effectiveness of Nb 2 CT x nanosheets in biomedical or other applications. The structure and phase of the Nb 2 CT x nanosheets were further examined by X‐ray diffraction (XRD) and X‐ray photoelectron spectroscopy (XPS).…”

Section: Figurementioning

confidence: 99%

Fluoride‐Free 2D Niobium Carbide MXenes as Stable and Biocompatible Nanoplatforms for Electrochemical Biosensors with Ultrahigh Sensitivity

et al. 2020

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Recently, 2D niobium carbide MXene has drawn vast attention due to its merits of large surface area, good metallic conductivity, and tunable band gap, making it desirable for various applications. However, the usage of highly toxic fluoride-containing etchant and quite long etching time in the conventional synthesis route has greatly hindered further exploration of MXene, especially restricting its biomedical application. Herein, novel fluoride-free Nb 2 CT x nanosheets are prepared by a facile strategy of electrochemical etching (E-etching) exfoliation. Taking advantage of rapid aluminum clearance, excellent chemical stability, and biocompatibility from the MXene by E-etching, fluoride-free Nb 2 CT x /acetylcholinesterase-based biosensors are constructed for phosmet detection with the limit of detection down to 0.046 ng mL −1. The fabricated Nb 2 CT x-based biosensor is superior to the counterpart from hydrofluoric acid-etched Nb 2 CT x , indicating that fluoride-free MXene can enhance the enzyme activity and electron transfer in the biosensor. The results prove that the fluorine-free MXene shows promise for developing biosensors with high performance of ultrahigh sensitivity and selectivity. It is highly expected that the fluoride-free MXene as a stable and biocompatible nanoplatform has great potential to be expanded to many other biomedical fields. MXenes as an emerging class of 2D materials are composed of layered transition metal carbides or nitrides with high conductivity, good hydrophilicity, superior optical, and mechanical properties. [1] MXenes have been developed in various applications, such as electrochemical catalysis, [2] medical devices, [3] energy conversion, and storage. [4] MXenes can be generally classified as M n+1 X n T x (n = 1, 2, or 3) where n + 1 layers of transition metals M (e.g., Sc, Ti, V, and Nb) are interleaved with n

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“…Sodium fluoride (NaF), one of the most frequently used fluoride compound is composed of Na + and F − [1]. The solubility of NaF is about 42 g/L (1 mol/L) at room temperature, and it increases very slowly with the increase in temperature [2].…”

Section: Introductionmentioning

confidence: 99%

Separation and recovery of NaF from fluorine containing solution by the common ion effect of Na+

Wang

2018

Heliyon

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The separation and recovery of NaF from fluorine containing solution by the common ion effect of Na+ was studied. The solubility of NaF in the solutions of NaCl, NaNO3, Na2CO3, Na2SO4 and NaOH at 30 °C was determined. It was found that when the compound containing sodium, such as Na2CO3 or Na2SO4 was added into NaF saturated solution to product the common ion effect of Na+, most of the NaF can be crystallized without evaporating concentration, and the added Na2CO3 or Na2SO4 can be recovered by cooling crystallization. Combining cooling crystallization with the common ion effect of Na+, different processes can be designed to recover NaF from different fluorine containing solutions. This will have a significant impact on the treatment of fluorine containing wastewater and the recycling of fluorine resources.

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Toxicity assessment of sodium fluoride in Drosophila melanogaster after chronic sub-lethal exposure

Cited by 58 publications

References 46 publications

Protective role of resveratrol, a natural polyphenol, in sodium fluoride-induced toxicity inDrosophila melanogaster

Protective role of resveratrol, a natural polyphenol, in sodium fluoride-induced toxicity inDrosophila melanogaster

Fluoride‐Free 2D Niobium Carbide MXenes as Stable and Biocompatible Nanoplatforms for Electrochemical Biosensors with Ultrahigh Sensitivity

Separation and recovery of NaF from fluorine containing solution by the common ion effect of Na+

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