Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos ( Danio rerio ): A multi biomarker study

Maharajan, Kannan; Muthulakshmi, Sellamani; Nataraj, Bojan; Ramesh, Mathan; Kadirvelu, K.

doi:10.1016/j.aquatox.2018.01.010

Cited by 157 publications

(69 citation statements)

References 101 publications

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“…In contrast, no negative effects of diclofenac on embryo development have been reported in common carp (Stepanova et al, ) and brown trout (Schwarz et al, ). In ecotoxicological assays of chemicals, zebrafish are increasingly used to examine abnormal embryogenesis, and there are many reports that abnormal embryogenesis is induced in zebrafish by various chemicals including agricultural chemicals (Cao et al, ; Jia, Mao, Zhang, Zhang, & Jiang, ; Maharajan, Muthulakshmi, Nataraj, Ramesh, & Kadirvelu, ; Sulukan et al, ; Yao, Yu, Zhou, Xiang, & Xu, ), pharmaceuticals (Chen et al, ; Félix et al, ; Kovács et al, ; present study) and metals (Horie, Yamagishi, Koshio, et al, ; Sun et al, ; Yin et al, ). These studies suggest that zebrafish embryos are particularly sensitive to chemical exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Benato et al (2013) reported that knockdown of autophagy/beclin-1 regulator 1 (ambra1) in zebrafish leads to incomplete embryogenesis due to severe defects in organogenesis. Exposure to various environmental chemicals is known to induce abnormal development of the spine in zebrafish (Cao et al, 2016;Chen et al, 2014;Horie, Yamagishi, Koshio, et al, 2017;Jia et al, 2018;Maharajan et al, 2018), however, the mechanisms underlying this induction remain unclear, so further studies are needed.…”

Section: Discussionmentioning

confidence: 99%

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The non‐steroidal anti‐inflammatory drug diclofenac sodium induces abnormal embryogenesis and delayed lethal effects in early life stage zebrafish (Danio rerio)

Horie

Yamagishi

Yagi

et al. 2018

J of Applied Toxicology

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Diclofenac sodium, a non‐steroidal anti‐inflammatory drug widely used in both human and veterinary medicine, has been detected in aquatic environments; therefore, its ecotoxicological effects on aquatic organisms need to be clarified. Recently, toxicity testing using zebrafish (Danio rerio) embryos has been recommended from the point of view of animal welfare; therefore, we investigated the suitability of using sub‐lethal endpoints observed during embryogenesis for predicting lethal effects in early life stage zebrafish exposed to diclofenac sodium. After exposure to diclofenac sodium (0.4‐7.0 mg/L) from 2 hours post‐fertilization to 30 days post‐hatching, abnormal embryogenesis, characterized by the presence of edema and body curvature, was observed in the 7.0 mg/L exposure group but not in any other groups including controls. The body curvature was found to be the result of abnormal development of the spine. All abnormal embryos hatched without delay, but died within 1 week after hatching, suggesting that the combination of the sub‐lethal endpoints of edema and abnormal development of the spine during embryogenesis may predict lethal effects in early life stage zebrafish exposed to diclofenac sodium. Further investigations to verify these findings are needed. The value of the no observed effect concentrations for the embryogenesis, survival and growth endpoints were 3.5, 1.8 and >3.5 mg/L, respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The non‐steroidal anti‐inflammatory drug diclofenac sodium induces abnormal embryogenesis and delayed lethal effects in early life stage zebrafish (Danio rerio)

Horie

Yamagishi

Yagi

et al. 2018

J of Applied Toxicology

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“…Our results support these findings in this study. Maharajan et. al., (2018) reported that pyriproxyfen could cause harmful effect on early developmental stages such as egg and larvae of zebrafish at higher concentration.…”

Section: Discussionmentioning

confidence: 99%

“…al., (2018) reported that pyriproxyfen could cause harmful effect on early developmental stages such as egg and larvae of zebrafish at higher concentration. They showed that these damages that will occur during the development stage of organs and tissues such as liver, pancreas or heart will affect the whole life of the fish (Maharajan et. al., 2018).…”

Section: Discussionmentioning

confidence: 99%

Some oxidative stress parameters in heart tissue of Zebrafish (Danio reiro) caused by mancozeb

Kayhan

Kaymak

Duruel

et al. 2019

EgeJFAS

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The potential toxic effects of mancozeb exposure on some antioxidant enzyme were investigated on heart tissue of zebrafish in this study. Zebrafish groups were exposed to different doses of mancozeb (Group A: 5 mgL-1 and Group B: 7.5 mgL-1) for 120 hours. In this study, catalase (CAT) activity, malondialdehyde (MDA) level and total protein (TP) level were determined with spectrophotometer. Our results showed that CAT activity was found 2,541±0,771 mg L-1 in A group and 2,011±0,201 mg L-1 in B group in this study. CAT and MDA activity levels decreased in the experiment group according to control group. MDA levels were found 0,025±0,003 mg L-1 in A group and 0,025±0,003 mg L-1 in B group. TP levels were found 9,75±1,51 mg L-1 in A group and 10,18±0,32 mg L-1 in B group. TP levels increased in the all experiment groups according to control group. We observed that the changes in the CAT activity and MDA levels were time and as well as mancozeb dose dependent. As a result mancozeb is a very toxic substance for zebrafish and other aquatic organisms.

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“…Pesticidas podem, em longo prazo, prejudicar a saúde humana e de outros animais, devido à exposição crônica aos resíduos do princípio ativo e de seus metabólitos no ambiente e nos alimentos (Houk, 1992), podendo gerar efeitos adversos, como disfunção nas vias bioquímicas e instabilidade genética (Wilczek et al, 2016;Ahmadi et al, 2018;Maharajan et al, 2018;Hong et al, 2018;Khan et al, 2018).…”

Section: Introductionunclassified

Potencial toxicogenético de inseticidas neonicotinóides em diferentes sistemas in vivo.

Morais¹

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Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos ( Danio rerio ): A multi biomarker study

Cited by 157 publications

References 101 publications

The non‐steroidal anti‐inflammatory drug diclofenac sodium induces abnormal embryogenesis and delayed lethal effects in early life stage zebrafish (Danio rerio)

The non‐steroidal anti‐inflammatory drug diclofenac sodium induces abnormal embryogenesis and delayed lethal effects in early life stage zebrafish (Danio rerio)

Some oxidative stress parameters in heart tissue of Zebrafish (Danio reiro) caused by mancozeb

Potencial toxicogenético de inseticidas neonicotinóides em diferentes sistemas in vivo.

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