Toxicity and pharmacokinetics of the antibiotic fumagillin in yearling rainbow trout (Salmo gairdneri)

Laurén, Darrel Jon; Wishkovsky, A.; Groff, J. M.; Hedrick, Ronald P.; Hinton, David E.

doi:10.1016/0041-008x(89)90173-7

Cited by 32 publications

(18 citation statements)

References 10 publications

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“…This may be due to the accumulation of inflammatory cells associated with chromium toxicity [63]. Epithelial degeneration of tubule was earlier reported in fish exposed to higher doses of antibiotics [64, 65]. …”

Section: Discussionmentioning

confidence: 89%

Chromium-induced biochemical, genotoxic and histopathologic effects in liver and kidney of goldfish, carassius auratus

Velma

Tchounwou

2010

Mutation Research/Genetic Toxicology and Environmental Mutagene

141

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Fish constitute an excellent model to understand the mechanistic aspects of metal toxicity vis-à-vis oxidative stress in aquatic ecosystems. Hexavalent chromium (Cr (VI)), due to its redox potential can induce oxidative stress (OS) in fish and impair their health. In the present investigation, we hypothesize that OS plays a key role in chromium induced toxicity in goldfish; leading to the production of reactive oxygen species (ROS) such as O · 2 , H 2 O 2 , OH · , and subsequent modulation of the activities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), metallothioneins (MT), glutathione proxidase (GPx), genotoxicity and histopathology. To test this hypothesis, antioxidant enzymes, DNA damage and histopathology assays were performed in liver and kidney tissues of goldfish exposed to different concentrations of Cr (VI) (LC 12.5 , LC 25 and LC 50 ) following 96h static renewal bioassay. The results of this study clearly show that the fish experienced OS as characterized by significant modulation of enzyme activities, induction of DNA damage and microscopic morphological changes in the liver and kidney. In both tissues, CAT activity was decreased whereas SOD activity and hydroperoxide levels were increased. In addition, GPx activity also increased significantly in higher test concentrations, especially in the kidney. MT induction and DNA damage were observed in both tissues in a concentration dependent manner. Microscopic examination of organ morphology indicated degeneration of liver tissue and necrosis of central vein. Necrosis of kidney tubular epithelial cells and tubules was observed at higher Cr (VI) concentrations. Taking together the findings of this study are helpful in organ-specific risk assessment of Cr (VI)-induced oxidative stress, genotoxicity and histopathology in fish.

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Section: Discussionmentioning

confidence: 89%

Chromium-induced biochemical, genotoxic and histopathologic effects in liver and kidney of goldfish, carassius auratus

Velma

Tchounwou

2010

Mutation Research/Genetic Toxicology and Environmental Mutagene

141

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“…Splenic and renal atrophy occurred in all the medicated groups. In other studies, administration of the drug to rainbow trout adults (0.25 or 1.0 g drug/ kg feed, at 1% biomass per day) resulted in similar histopathological changes and caused a significant decrease in the hematocrit values (LAUREN et al, 1989). The effects of fumagillin on the hematopoietic tissues (kidney and spleen) may be due to concentration of the drug or its metabolites in those sites.…”

Section: Discussionmentioning

confidence: 94%

Efficacy of fumagillin against proliferative kidney disease and its toxic side effects in rainbow trout (Oncorhynchus mykiss) fingerlings.

Wishkovsky¹,

Groff²,

Laurén³

et al. 1990

Fish Pathol.

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“…The use of these drugs on experimental fish, although potentially eliminating the pathogen, could also introduce other changes in the host, confounding research (Baker 2003). Toxic effects of Fumigillin DCH have been observed in salmonids (Laurén et al 1989); thus its utility would be limited to the treatment of fish not used as experimental animals (e.g., broodstock). Ultimately, the elimination of P. neurophilia from existing lines of zebrafish may require rederivation of those lines using the methods described by Kent and colleagues (2011).…”

Section: Other Considerationsmentioning

confidence: 99%

Microsporidiosis in Zebrafish Research Facilities

Sanders¹,

Watral²,

Kent³

2012

ILAR Journal

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Pseudoloma neurophilia (Microsporidia) is the most common pathogen detected in zebrafish (Danio rerio) from research facilities. The parasite infects the central nervous system and muscle and may be associated with emaciation and skeletal deformities. However, many fish exhibit sub-clinical infections. Another microsporidium, Pleistophora hyphessobryconis, has recently been detected in a few zebrafish facilities. Here, we review the methods for diagnosis and detection, modes of transmission, and approaches used to control microsporidia in zebrafish, focusing on P. neurophilia. The parasite can be readily transmitted by feeding spores or infected tissues, and we show that cohabitation with infected fish is also an effective means of transmission. Spores are released from live fish in various manners, including through the urine, feces, and sex products during spawning. Indeed, P. neurophilia infects both the eggs and ovarian tissues, where we found concentrations ranging from 12,000 to 88,000 spores per ovary. Hence, various lines of evidence support the conclusion that maternal transmission is a route of infection: spores are numerous in ovaries and developing follicles in infected females, spores are present in spawned eggs and water from spawning tanks based on polymerase chain reaction tests, and larvae are very susceptible to the infection. Furthermore, egg surface disinfectants presently used in zebrafish laboratories are ineffective against microsporidian spores. At this time, the most effective method for prevention of these parasites is avoidance.

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Toxicity and pharmacokinetics of the antibiotic fumagillin in yearling rainbow trout (Salmo gairdneri)

Cited by 32 publications

References 10 publications

Chromium-induced biochemical, genotoxic and histopathologic effects in liver and kidney of goldfish, carassius auratus

Chromium-induced biochemical, genotoxic and histopathologic effects in liver and kidney of goldfish, carassius auratus

Efficacy of fumagillin against proliferative kidney disease and its toxic side effects in rainbow trout (Oncorhynchus mykiss) fingerlings.

Microsporidiosis in Zebrafish Research Facilities

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