Toxicity and neuropharmacology of cyclopiazonic acid

Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters

“…In addition, we were able to determine the identity of the metabolite produced by predicted gene cluster 55 as CPA. CPA has the potential to become an overlooked mycotoxin that could have significant health risks (Nishie et al, 1985). Our data show that, under conditions favourable for the production of AF, CPA will also probably be produced, assuming that the strain has the capacity to produce CPA.…”

Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters

“…In addition, we were able to determine the identity of the metabolite produced by predicted gene cluster 55 as CPA. CPA has the potential to become an overlooked mycotoxin that could have significant health risks (Nishie et al, 1985). Our data show that, under conditions favourable for the production of AF, CPA will also probably be produced, assuming that the strain has the capacity to produce CPA.…”

A strategy for screening and identifying mycotoxins in herbal medicine using ultra‐performance liquid chromatography with tandem quadrupole time‐of‐flight mass spectrometry

“…CPA caused mild cellular degenerative changes in the myocardium and in several other organs where ballooning of nuclei, especially in ductal epithelia, was also characteristic. The toxicity of CPA was also studied by Nishie et al in mice and rabbits by intraperitoneal injection of purified compound . The LD 50 of CPA (i.p.)…”

Integrating seed microbiome knowledge into restoration and ex situ conservation of native Australian plants

“…The fungi represented a range of different genera, although were dominated by species of Penicillium, Banksiamyces and Alternaria. Penicillium species have been associated with producing mycotoxins such as citromycetin (Grove and Brian 1951), citroviridin (Nishie et al 1988) and citrinin (Flajs and Peraica 2009) and, hence, have been thought to play a key role in defence against pathogens. They also have been associated with causing seed disease and decay (Duduk et al 2017).…”

Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters

“…In addition, we were able to determine the identity of the metabolite produced by predicted gene cluster 55 as CPA. CPA has the potential to become an overlooked mycotoxin that could have significant health risks (Nishie et al, 1985). Our data show that, under conditions favourable for the production of AF, CPA will also probably be produced, assuming that the strain has the capacity to produce CPA.…”

A strategy for screening and identifying mycotoxins in herbal medicine using ultra‐performance liquid chromatography with tandem quadrupole time‐of‐flight mass spectrometry

“…CPA caused mild cellular degenerative changes in the myocardium and in several other organs where ballooning of nuclei, especially in ductal epithelia, was also characteristic. The toxicity of CPA was also studied by Nishie et al in mice and rabbits by intraperitoneal injection of purified compound . The LD 50 of CPA (i.p.)…”

Integrating seed microbiome knowledge into restoration and ex situ conservation of native Australian plants

“…The fungi represented a range of different genera, although were dominated by species of Penicillium, Banksiamyces and Alternaria. Penicillium species have been associated with producing mycotoxins such as citromycetin (Grove and Brian 1951), citroviridin (Nishie et al 1988) and citrinin (Flajs and Peraica 2009) and, hence, have been thought to play a key role in defence against pathogens. They also have been associated with causing seed disease and decay (Duduk et al 2017).…”

Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters

“…In addition, we were able to determine the identity of the metabolite produced by predicted gene cluster 55 as CPA. CPA has the potential to become an overlooked mycotoxin that could have significant health risks (Nishie et al, 1985). Our data show that, under conditions favourable for the production of AF, CPA will also probably be produced, assuming that the strain has the capacity to produce CPA.…”

A strategy for screening and identifying mycotoxins in herbal medicine using ultra‐performance liquid chromatography with tandem quadrupole time‐of‐flight mass spectrometry

“…CPA caused mild cellular degenerative changes in the myocardium and in several other organs where ballooning of nuclei, especially in ductal epithelia, was also characteristic. The toxicity of CPA was also studied by Nishie et al in mice and rabbits by intraperitoneal injection of purified compound . The LD 50 of CPA (i.p.)…”

Integrating seed microbiome knowledge into restoration and ex situ conservation of native Australian plants

“…The fungi represented a range of different genera, although were dominated by species of Penicillium, Banksiamyces and Alternaria. Penicillium species have been associated with producing mycotoxins such as citromycetin (Grove and Brian 1951), citroviridin (Nishie et al 1988) and citrinin (Flajs and Peraica 2009) and, hence, have been thought to play a key role in defence against pathogens. They also have been associated with causing seed disease and decay (Duduk et al 2017).…”