Toxicity and imaging of multi-walled carbon nanotubes in human macrophage cells

Cheng, Chunming; Müller, Karin H.; Kozioł, Krzysztof; Skepper, Jeremy N.; Midgley, Paul A.; Welland, Mark E.; Porter, Alexandra E.

doi:10.1016/j.biomaterials.2009.04.019

Cited by 178 publications

(115 citation statements)

References 40 publications

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“…Cheng et al (Cheng et al, 2009) found that MWNTs entered the macrophages through the plasma membrane into the cytoplasm and the nucleus, which may result in necrosis and degeneration. Apoptotic cell death was found with a higher dose at 3.06 μg/cm 2 .…”

Section: Carbon Nanotube (Cnt) Electrodementioning

confidence: 99%

Electrical Stimulation in Tissue Regeneration

Meng¹,

Rouabhia²,

Zhang³

2011

Applied Biomedical Engineering

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Section: Carbon Nanotube (Cnt) Electrodementioning

confidence: 99%

Electrical Stimulation in Tissue Regeneration

Meng¹,

Rouabhia²,

Zhang³

2011

Applied Biomedical Engineering

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“…but it is important to assess their toxicity before they are used on a wide scale in biological systems. One toxic biological effect which has been observed is decreased cell viability through membrane damage and subcellular organelle dysfunction; this has been reported by several authors in such cells as human macrophages (Cheng et al 2009). human keratinocytes (Manna et al 2005).…”

Section: Cnt Toxicity In Biological Applicationsmentioning

confidence: 75%

Local heating of molecular motors using single carbon nanotubes

Inoue

Ishijima

2016

Biophys Rev

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Temperature globally affects all chemical processes and biomolecules in living cells. Elevating the temperature of an entire cell accelerates so many biomolecular reactions simultaneously that it is difficult to distinguish the various mechanisms involved. The ability to localize temperature changes to the nanometer range within a cell could provide a powerful new tool for regulating biomolecular activity at the level of individual molecules. The search for a nanoheater for biological research has prompted experiments with carbon nanotubes (CNTs), which have the highest conductivity of any known material. The adsorption of skeletal muscle myosin molecules along the length of single multi-walled CNTs (~10 μm) has allowed researchers to observe the ATP-driven sliding of fluorescently labeled actin filaments. In one study, red-laser irradiation focused on one end of a myosin-coated CNT was used to heat myosin motors locally without directly heating the surrounding water; this laser irradiation instantly accelerated the actin-filament sliding speeds from~6 to~12 μm/s in a reversible manner, indicating a local, real-time heating of myosin motors by approximately Δ12 K. Calculation of heat transfer using the finite element method, based on the estimated temperature along a single CNT with a diameter of 170 nm, indicated a high thermal conductivity of~1540 Wmtion, consistent with values measured in vacuum in earlier studies. Temperature distribution indicated by half-decrease distances was~3660 nm along the length of the CNT and 250 nm perpendicular to the length. These results suggest that single-CNT-based heating at the nanometer-or micrometerrange could be used to regulate various biomolecules in many areas of biological, physical, and chemical research.

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“…However, the extent of effect of metallic residues is still unclear. In a recent comparative study high purity MWNTs (less than 0.0005% Fe) were more toxic to human macrophages than the Fe 2 O 3 catalyst itself [24].…”

Section: 2carbonaceous and Non-carbonaceous Impurities Solvent Rementioning

confidence: 97%

Formulating Nanomedicines: Focus on Carbon Nanotubes as Novel Nanoexcipients

Földvári

2010

KEM

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Many recently designed drug delivery systems have been constructed from nano-sized components that serve as the carrier or targeting ligand for a therapeutic agent. Even though these materials have been regarded previously as inert or non-active components of dosage forms, they are now recognized as sometimes being even more important than the drug itself. Hence, it is becoming increasingly imperative that the pharmaceutically relevant properties, including identity, physicochemical characteristics, purity, solubility and toxicity, of these functional nano-excipients be fully characterized. Carbon nanotubes (CNTs) are novel nanomaterials made of carbon atoms that have wide application potential in many areas of nanomedicine. However, because of their significant potential, CNTs, as building blocks for nanomedicines, need to be characterized more fully. Studies to date indicate that both physical and chemical properties of CNTs play an important role in their interactions with cells. Therefore, a full understanding of the physical properties of CNTs, such as identity, chirality, particle size, aspect ratio, morphology and dispersion state, as well as chemical properties such as purity, defect sites and types and functional groups, will be essential to develop a full characterization panel of these versatile nanomaterials.

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Toxicity and imaging of multi-walled carbon nanotubes in human macrophage cells

Cited by 178 publications

References 40 publications

Electrical Stimulation in Tissue Regeneration

Electrical Stimulation in Tissue Regeneration

Local heating of molecular motors using single carbon nanotubes

Formulating Nanomedicines: Focus on Carbon Nanotubes as Novel Nanoexcipients

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