Toxicity and endocrine-disrupting potential of PM2.5: Association with particulate polycyclic aromatic hydrocarbons, phthalate esters, and heavy metals

Zhou, Qinghua; Chen, Jin‐Yuan; Zhang, Junfan; Zhou, Feifei; Zhao, Jingjing; Wei, Xiuzhen; Zheng, Kun; Wu, Jiangqin; Li, Bingjie; Pan, Bingjun

doi:10.1016/j.envpol.2021.118349

Cited by 28 publications

(9 citation statements)

References 48 publications

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“…Inhalation has been demonstrated as one of the most important pathways of human exposure to airborne volatile or semivolatile compounds. , This is particularly true for PAEs and likely for their replacements, to which humans are exposed via similar routes. For example, DEHP bound with airborne fine particles has been reported to contribute substantially to the endocrine-disrupting potential of PM 2.5 . However, toxicity evaluations of the majority of NPPs are limited and generally focused on few selected ones (e.g., DPGDB, TMPDMiB, ATBC, TBC, and TEC). − In particular, toxicity assessment of inhalational exposure to NPPs remains scarce.…”

Section: Resultsmentioning

confidence: 99%

“…For example, DEHP bound with airborne fine particles has been reported to contribute substantially to the endocrine-disrupting potential of PM 2.5 . 45 However, toxicity evaluations of the majority of NPPs are limited and generally focused on few selected ones (e.g., DPGDB, TMPDMiB, ATBC, TBC, and TEC). 46−48 In particular, toxicity assessment of inhalational exposure to NPPs remains scarce.…”

Section: Chemicals and Reagents Reference Standards Of 24mentioning

confidence: 99%

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Non-Phthalate Ester Plasticizers in Airborne Fine Particles from Chinese Cities: Broad Distributions and Spatiotemporal Trends

Song,

Tao,

Cui

et al. 2023

Environ. Sci. Technol. Lett.

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In contrast with phthalate esters (PAEs), many non-PAE plasticizers (NPPs) remain poorly characterized in their environmental distribution. Our work explored the spatial distributions of 44 NPPs in airborne fine particles (PM2.5) from 13 Chinese cities as well as the temporal change of contamination at a selected city (Jinan, Shandong Province). The results revealed ubiquitous distributions of several groups of NPPs in the ambient environment, such as oleates, adipates, citrates, and isobutyrates. The total abundance of NPPs (ΣNPPs) ranged from 0.37 to 54.7 ng/m3, and the ratios of ΣNPPs to ΣPAEs ranged from 0.06 to 4.17 across the study sites. The spatial variations in ΣNPPs appeared to be significantly associated with the gross domestic product of the cities, indicating a link between economic prosperity and environmental releases of NPPs. The ratios of ΣNPPs to ΣPAEs also exhibited a significant temporal increase during the period of 2015–2020 in the study site located in Jinan, providing strong evidence of the increasing applications of NPPs relative to PAEs in previous years. Our work constitutes one of the first reports on the spatiotemporal distributions of NPPs over a large geographic range.

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Section: Resultsmentioning

confidence: 99%

Section: Chemicals and Reagents Reference Standards Of 24mentioning

confidence: 99%

Non-Phthalate Ester Plasticizers in Airborne Fine Particles from Chinese Cities: Broad Distributions and Spatiotemporal Trends

Song,

Tao,

Cui

et al. 2023

Environ. Sci. Technol. Lett.

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“…Additionally, PM 2.5 may absorb endocrine-disrupting chemicals (EDCs) such as phthalate esters, bisphenol A, alkylphenols and natural and synthetic sex hormones that may exert estrogenic and anti-androgenic activities [ 48 , 49 ]. As AGD is considered as an androgen-sensitive biomarker, we hypothesize that these EDCs in PM 2.5 may act as androgen receptor antagonists and influence the AGD length in offspring.…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to fine particulate matter and newborn anogenital distance: a prospective cohort study

et al. 2023

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Background Considerable attention has been paid to reproductive toxicity of fine particulate matter (PM2.5). However, the relationship between prenatal PM2.5 exposure and anogenital distance (AGD) has not been well studied. We aim to investigate the potential effects of prenatal exposure to PM2.5 on newborn AGD. Methods Prenatal PM2.5 exposure of 2332 participates in Shanghai (2013–2016) was estimated using high-performance machine learning models. Anoscrotal distance (AGDas) in male infants and anofourchette distance (AGDaf) in female infants were measured by well-trained examiners within 3 days after birth. We applied multiple linear regression models and multiple informant models to estimate the association between prenatal PM2.5 exposure and AGD. Results Multiple linear regression models showed that a 10 μg/m3 increase in PM2.5 exposure during full pregnancy, the second and third trimesters was inversely associated with AGDas (adjusted beta = − 1.76, 95% CI: − 2.21, − 1.31; − 0.73, 95% CI: − 1.06, − 0.40; and − 0.52; 95% CI: − 0.87, − 0.18, respectively) in males. A 10 μg/m3 increase in PM2.5 exposure during the full pregnancy, the first, second, and third trimesters was inversely associated with AGDaf (adjusted beta = − 4.55; 95% CI: − 5.18, − 3.92; − 0.78; 95% CI: − 1.10, − 0.46; − 1.11; 95% CI: − 1.46, − 0.77; − 1.45; 95% CI: − 1.78, − 1.12, respectively) in females after adjusting for potential confounders. Multiple informant models showed consistent but slightly attenuated associations. Conclusion Our study observed a significant association between gestational PM2.5 exposure during pregnancy and shortened AGD in newborns, and provided new evidence on potential reproductive toxicity of prenatal PM2.5 exposure.

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“…In terms of binding with other pollutants, polycyclic aromatic hydrocarbons were the most common, followed by heavy metals. The combination of PAHs and PM 2.5 was mainly from vehicle emissions, industrial activities, and fuel burning [30,31]. This also indicated that the synergistic effects of PM 2.5 combining with other pollutants were beginning to be explored based on their characteristics.…”

Section: Keyword Co-occurrence Analysis For Pm 25 and Cancermentioning

confidence: 99%

Bibliometric Analysis Reveals the Progress of PM2.5 in Health Research, Especially in Cancer Research

Xie

Shi

Yuan

et al. 2023

IJERPH

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PM2.5 has an aerodynamic diameter of less than or equal to 2.5 microns due to its inherent physical and chemical properties so that it can enter the alveoli through the respiratory tract for blood gas exchange. Numerous studies have shown that PM2.5 is a serious air pollutant that poses a wide range of health risks, especially for cancer. Bibliometric methods were employed to have comprehensively analyzed the research of PM2.5 in cancer for about a decade in Web of Science to identify hotspots and trends using VOSviewer, CiteSpace, and R. The field has undergone overall growth in the past decade. As research on PM2.5 in health deepens, cancer related to it expanded beyond the respiratory system to the digestive system, urinary system, female gonadal axis, breast cancer and other cancers. Another observation is that research on PM2.5 in cancer has progressed in the mechanisms of deterioration, such as the role of matrix metalloproteinases in cancer. In addition, research on the risks of PM2.5 in combination with polycyclic aromatic hydrocarbons and heavy metals has also emerged. Results showed that there are relatively more studies on PM2.5 in high-latitude countries, which may be due to different national conditions, such as climate and coal combustion. Our research has combed through the progress of PM2.5 in cancer research and provided a supplement for developing pollution prevention ideas with different national conditions in this field.

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Toxicity and endocrine-disrupting potential of PM2.5: Association with particulate polycyclic aromatic hydrocarbons, phthalate esters, and heavy metals

Cited by 28 publications

References 48 publications

Non-Phthalate Ester Plasticizers in Airborne Fine Particles from Chinese Cities: Broad Distributions and Spatiotemporal Trends

Non-Phthalate Ester Plasticizers in Airborne Fine Particles from Chinese Cities: Broad Distributions and Spatiotemporal Trends

Prenatal exposure to fine particulate matter and newborn anogenital distance: a prospective cohort study

Bibliometric Analysis Reveals the Progress of PM2.5 in Health Research, Especially in Cancer Research

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